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Microbiology

D-Index
81
Citations
26187
World Ranking
1087
National Ranking
495

Overview

Hongbo Chi is a researcher affiliated with St. Jude Children's Research Hospital in the United States, specializing in fields related to immunology, microbiology, and molecular biology. Their body of work spans across multiple interrelated disciplines including immunology, medicine, biochemistry, genetics, and molecular biology with a strong focus on immune system function and cellular interactions.

The scientist's primary areas of study include:

  • Immunology
  • Molecular Biology
  • Oncology
  • Infectious Diseases
  • Genetics

The main topics addressed in their research involve:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • CAR-T Cell Therapy Research
  • Immune Cells in Cancer
  • Immunotherapy and Immune Responses
  • Single-cell and Spatial Transcriptomics
  • CRISPR and Genetic Engineering

Hongbo Chi has published extensively in several prominent scientific venues, with frequent publications appearing in:

  • Nature
  • Nature Immunology
  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Immunity

Notable recent publications include:

  • Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression (2020, Neuron)
  • Lipid signalling enforces functional specialization of Treg cells in tumours (2021, Nature)
  • Metabolic adaptation of lymphocytes in immunity and disease (2022, Immunity)
  • Signaling networks in immunometabolism (2020, Cell Research)
  • Lipid metabolism in T cell signaling and function (2022, Nature Chemical Biology)

Their research collaborations have involved multiple frequent co-authors, including:

  • Hao Shi
  • Nicole M. Chapman
  • Yogesh Dhungana
  • Hongling Huang
  • Jordy Saravia

Best Publications

  • The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

    Ruoning Wang;Christopher P. Dillon;Lewis Zhichang Shi;Sandra Milasta

  • HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

    Lewis Z. Shi;Ruoning Wang;Gonghua Huang;Peter Vogel

  • Regulation and function of mTOR signalling in T cell fate decisions

    Hongbo Chi

  • mTORC1 couples immune signals and metabolic programming to establish T reg -cell function

    Hu Zeng;Kai Yang;Caryn Cloer;Geoffrey Neale

  • Metabolic coordination of T cell quiescence and activation.

    Nicole M. Chapman;Mark R. Boothby;Hongbo Chi

  • Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses.

    Hongbo Chi;Sean P. Barry;Rachel J. Roth;J. Julie Wu

  • Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression

    Bing Bai;Xusheng Wang;Yuxin Li;Ping Chung Chen

  • Helper T cell differentiation.

    Jordy Saravia;Nicole M. Chapman;Hongbo Chi

  • Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

    Jun Wei;Lingyun Long;Kai Yang;Cliff Guy

  • The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.

    Guangwei Liu;Samir Burns;Gonghua Huang;Kelli Boyd

  • Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection

    Christopher R. Lupfer;Paul G Thomas;Paras K. Anand;Peter Vogel

  • Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination.

    Gonghua Huang;Lewis Zhichang Shi;Hongbo Chi

  • T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

    Kai Yang;Sharad Shrestha;Hu Zeng;Peer W.F. Karmaus

  • Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

    Jun Wei;Lingyun Long;Wenting Zheng;Yogesh Dhungana

  • Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses.

    Sharad Shrestha;Kai Yang;Cliff Guy;Peter Vogel

  • Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation

    Haiyan Tan;Kai Yang;Yuxin Li;Timothy I. Shaw

  • Lipid signalling enforces functional specialization of Treg cells in tumours

    Seon Ah Lim;Jun Wei;Thanh-Long M. Nguyen;Hao Shi

  • The S1P 1 -mTOR axis directs the reciprocal differentiation of T H 1 and T reg cells

    Guangwei Liu;Kai Yang;Samir Burns;Sharad Shrestha

  • mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.

    Hu Zeng;Sivan Cohen;Cliff Guy;Sharad Shrestha

  • Metabolic adaptation of lymphocytes in immunity and disease.

    Unknown

  • The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function

    Yisong Y Wan;Hongbo Chi;Min Xie;Michael D Schneider

  • The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function.

    Kai Yang;Geoffrey Neale;Douglas R Green;Weifeng He

Frequent Co-Authors

Geoffrey Neale
Geoffrey Neale St. Jude Children's Research Hospital
Richard A. Flavell
Richard A. Flavell Yale University
Peter Vogel
Peter Vogel St. Jude Children's Research Hospital
Junmin Peng
Junmin Peng St. Jude Children's Research Hospital
Thirumala-Devi Kanneganti
Thirumala-Devi Kanneganti St. Jude Children's Research Hospital
Douglas R. Green
Douglas R. Green St. Jude Children's Research Hospital
Demin Wang
Demin Wang Medical College of Wisconsin
Paul G. Thomas
Paul G. Thomas St. Jude Children's Research Hospital
John Easton
John Easton St. Jude Children's Research Hospital
Roger J. Davis
Roger J. Davis University of Massachusetts Chan Medical School

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