His primary scientific interests are in Cell biology, Signal transduction, PI3K/AKT/mTOR pathway, Immune system and T cell. His studies deal with areas such as CD28, Transcription factor, Immunology and Cellular differentiation as well as Cell biology. Within one scientific family, Hongbo Chi focuses on topics pertaining to Priming under Cellular differentiation, and may sometimes address concerns connected to Lymphocyte.
His Signal transduction study integrates concerns from other disciplines, such as Sphingosine, Receptor, Caspase 1, Kinase and Mitophagy. His PI3K/AKT/mTOR pathway research focuses on Immune tolerance and how it relates to Regulatory T cell. His biological study spans a wide range of topics, including Acquired immune system, Neuroinflammation, Interleukin 17 and Cell fate determination.
His primary areas of investigation include Cell biology, T cell, Immune system, Signal transduction and Immunology. His Cell biology research is multidisciplinary, incorporating perspectives in Transcription factor and Cellular differentiation. His studies examine the connections between T cell and genetics, as well as such issues in Acquired immune system, with regards to Dendritic cell.
His study in Immune system is interdisciplinary in nature, drawing from both Cancer research, Lymphocyte and Function. His research integrates issues of Kinase and Cell growth in his study of Signal transduction. Hongbo Chi has included themes like Regulatory T cell and Immune tolerance in his PI3K/AKT/mTOR pathway study.
His scientific interests lie mostly in Cell biology, T cell, Effector, Immune system and Acquired immune system. His work on Cell biology is being expanded to include thematically relevant topics such as Transcription factor. The concepts of his T cell study are interwoven with issues in Targeted therapy, Leukemia, Homeostasis and BATF.
His research on Effector also deals with topics like
Hongbo Chi mainly investigates Cell biology, T cell, Effector, Immune system and Acquired immune system. Hongbo Chi is involved in the study of Cell biology that focuses on mTORC1 in particular. He studied T cell and PI3K/AKT/mTOR pathway that intersect with Kinase.
His Effector study combines topics from a wide range of disciplines, such as Receptor, Cell therapy, BATF, T-cell receptor and Immunotherapy. In his work, Cellular differentiation, Dendritic cell, Regulatory T cell, Cell metabolism and Regulator is strongly intertwined with Signal transduction, which is a subfield of Immune system. His studies in Acquired immune system integrate themes in fields like Cellular metabolism, Transcriptional Networks, Neuroscience and Systems biology.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Ruoning Wang;Christopher P. Dillon;Lewis Zhichang Shi;Sandra Milasta.
HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Lewis Z. Shi;Ruoning Wang;Gonghua Huang;Peter Vogel.
Journal of Experimental Medicine (2011)
Regulation and function of mTOR signalling in T cell fate decisions
Nature Reviews Immunology (2012)
mTORC1 couples immune signals and metabolic programming to establish T reg -cell function
Hu Zeng;Kai Yang;Caryn Cloer;Geoffrey Neale.
Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses.
Hongbo Chi;Sean P. Barry;Rachel J. Roth;J. Julie Wu.
Proceedings of the National Academy of Sciences of the United States of America (2006)
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.
Guangwei Liu;Samir Burns;Gonghua Huang;Kelli Boyd.
Nature Immunology (2009)
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection
Christopher R. Lupfer;Paul G Thomas;Paras K. Anand;Peter Vogel.
Nature Immunology (2013)
Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis
Jun Wei;Lingyun Long;Kai Yang;Cliff Guy.
Nature Immunology (2016)
Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses.
Sharad Shrestha;Kai Yang;Cliff Guy;Peter Vogel.
Nature Immunology (2015)
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
Yisong Y Wan;Hongbo Chi;Min Xie;Michael D Schneider.
Nature Immunology (2006)
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below: