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Biology and Biochemistry

D-Index
76
Citations
29068
World Ranking
4948
National Ranking
2377

Overview

John Easton is affiliated with St. Jude Children's Research Hospital in the United States. Their research spans a range of topics primarily within biochemistry, genetics, molecular biology, and medicine.

They have contributed extensively to key areas such as:

  • Childhood Cancer Survivors' Quality of Life
  • Acute Lymphoblastic Leukemia research
  • Cancer Genomics and Diagnostics
  • Epigenetics and DNA Methylation
  • Neuroblastoma Research and Treatments
  • RNA modifications and cancer
  • Single-cell and spatial transcriptomics

Their work covers important subfields, including molecular biology, cancer research, pediatrics, perinatology and child health, public health, environmental and occupational health, and genetics.

John Easton's publishing record includes numerous papers in high-impact journals. Recent publications include:

  • "Accurate genomic variant detection in single cells with primary template-directed amplification," 2021, Proceedings of the National Academy of Sciences
  • "Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations," 2020, Nature Communications
  • "Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia," 2021, Nature Cancer
  • "EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma," 2021, Cancer Discovery
  • "Mutational Landscape and Patterns of Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia," 2020, Blood Cancer Discovery

The scientist often collaborates with other researchers, with frequent coauthors including Jinghui Zhang, Heather Mulder, Zhaoming Wang, Melissa M. Hudson, and Kirsten K. Ness, reflecting a network of ongoing collaborative efforts.

John Easton's research is regularly published in several key venues, among them:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Blood
  • Zenodo (CERN European Organization for Nuclear Research)

Best Publications

  • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

    Jinghui Zhang;Li Ding;Linda Holmfeldt;Gang Wu

  • Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

    K. G. Roberts;Y. Li;D. Payne-Turner;R. C. Harvey

  • Germline Mutations in Predisposition Genes in Pediatric Cancer

    Jinghui Zhang;Michael F. Walsh;Gang Wu;Michael N. Edmonson

  • The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

    Gang Wu;Alexander K Diaz;Alexander K Diaz;Barbara S Paugh;Sherri L Rankin

  • The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia

    Yu Liu;John Easton;Ying Shao;Jamie Maciaszek

  • Novel mutations target distinct subgroups of medulloblastoma

    Giles Robinson;Matthew Parker;Tanya A. Kranenburg;Charles Lu;Charles Lu

  • Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours

    Xiaotu Ma;Yu Liu;Yanling Liu;Ludmil B. Alexandrov

  • Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

    Jinghui Zhang;Gang Wu;Claudia P. Miller;Ruth G. Tatevossian

  • The genomic landscape of hypodiploid acute lymphoblastic leukemia

    Linda Holmfeldt;Lei Wei;Ernesto Diaz-Flores;Michael Walsh

  • Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

    Xiang Chen;Armita Bahrami;Alberto Pappo;John Easton

  • C11orf95 – RELA fusions drive oncogenic NF-κB signalling in ependymoma

    Matthew Parker;Kumarasamypet M. Mohankumar;Chandanamali Punchihewa;Ricardo Weinlich

  • mTOR and cancer therapy.

    J B Easton;P J Houghton

  • CREST maps somatic structural variation in cancer genomes with base-pair resolution

    Jianmin Wang;Charles G Mullighan;John Easton;Stefan Roberts

  • A novel retinoblastoma therapy from genomic and epigenetic analyses

    Jinghui Zhang;Claudia A. Benavente;Justina McEvoy;Jacqueline Flores-Otero

  • Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations

    Franck Tirode;Didier Surdez;Xiaotu Ma;Matthew Parker

  • The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias.

    Anna K. Andersson;Anna K. Andersson;Jing Ma;Jianmin Wang;Xiang Chen

  • Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia

    Xiaotu Ma;Michael Edmonson;Donald Yergeau;Donna M Muzny

  • The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

    Robert Huether;Li Dong;Xiang Chen;Gang Wu

  • Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology

    Ibrahim Qaddoumi;Wilda Orisme;Ji Wen;Teresa Santiago

  • Resolving medulloblastoma cellular architecture by single-cell genomics

    Volker Hovestadt;Volker Hovestadt;Kyle S. Smith;Laure Bihannic;Mariella G. Filbin;Mariella G. Filbin;Mariella G. Filbin

Frequent Co-Authors

Jinghui Zhang
Jinghui Zhang St. Jude Children's Research Hospital
James R. Downing
James R. Downing St. Jude Children's Research Hospital
Michael Rusch
Michael Rusch St. Jude Children's Research Hospital
Gang Wu
Gang Wu Washington University in St. Louis
Elaine R. Mardis
Elaine R. Mardis The Ohio State University
Charles G. Mullighan
Charles G. Mullighan St. Jude Children's Research Hospital
Richard K. Wilson
Richard K. Wilson Nationwide Children's Hospital
Sheila A. Shurtleff
Sheila A. Shurtleff St. Jude Children's Research Hospital
Li Ding
Li Ding Washington University in St. Louis
Michael A. Dyer
Michael A. Dyer St. Jude Children's Research Hospital

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