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Medicine

D-Index
114
Citations
72563
World Ranking
4628
National Ranking
251

Overview

Marcel Kool is affiliated with the German Cancer Research Center in Germany. Their research spans multiple areas within medicine and molecular biology, with significant contributions to oncology and cancer research. The scientist's work focuses on the molecular biology of cancer, genetics, neurology, and biochemistry, frequently intersecting with studies on chromatin remodeling, epigenetics, and DNA methylation.

Kool's recent publications address various aspects of cancer diagnostics and treatment, including pediatric cancers and brain tumors. Notable papers include:

  • Sarcoma classification by DNA methylation profiling, 2021, Nature Communications
  • An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity, 2020, Nature Communications
  • Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors, 2020, Nature Medicine
  • Germline Elongator mutations in Sonic Hedgehog medulloblastoma, 2020, Nature
  • Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma, 2020, Cancer Cell

The scientist has collaborated extensively with several co-authors, including:

  • Stefan M. Pfister
  • Andrey Korshunov
  • Johannes Gojo
  • David Jones
  • Kristian W. Pajtler

Marcel Kool's research findings have been published frequently in leading scientific venues, including:

  • Neuro-Oncology
  • Cancer Research
  • Acta Neuropathologica
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications

Their main fields of study highlight a strong emphasis on medicine and biochemistry, genetics, and molecular biology. Subfields of research include:

  • Molecular Biology
  • Genetics
  • Cancer Research
  • Neurology
  • Oncology

Key topics in their work cover a range of cancer-related and molecular mechanisms, such as:

  • Glioma Diagnosis and Treatment
  • Chromatin Remodeling and Cancer
  • Neuroblastoma Research and Treatments
  • Hedgehog Signaling Pathway Studies
  • Epigenetics and DNA Methylation
  • Cancer Genomics and Diagnostics
  • Protein Degradation and Inhibitors

Best Publications

  • Signatures of mutational processes in human cancer

    Ludmil B. Alexandrov;Serena Nik-Zainal;Serena Nik-Zainal;David C. Wedge;Samuel A. J. R. Aparicio

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • DNA methylation-based classification of central nervous system tumours

    David Capper;David Capper;David Capper;David T. W. Jones;Martin Sill;Volker Hovestadt

  • Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

    Jeremy Schwartzentruber;Andrey Korshunov;Xiao Yang Liu;David T.W. Jones

  • A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins

    Piet Borst;Raymond Evers;Marcel Kool;Jan Wijnholds

  • Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

    Dominik Sturm;Hendrik Witt;Hendrik Witt;Volker Hovestadt;Dong Anh Khuong-Quang

  • Molecular Subgroups of Medulloblastoma: The Current Consensus

    Michael D. Taylor;Paul A. Northcott;Andrey Korshunov;Marc Remke;Marc Remke

  • The landscape of genomic alterations across childhood cancers

    Susanne N. Gröbner;Barbara C. Worst;Joachim Weischenfeldt;Joachim Weischenfeldt;Ivo Buchhalter

  • Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.

    M. Kool;M. De Haas;G. L. Scheffer;R. J. Scheper

  • Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

    Marcel Kool;Andrey Korshunov;Marc Remke;Marc Remke;David T.W. Jones

  • Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

    Kristian W. Pajtler;Kristian W. Pajtler;Hendrik Witt;Martin Sill;David T.W. Jones

  • Subgroup-specific structural variation across 1,000 medulloblastoma genomes

    Paul A. Northcott;Paul A. Northcott;David J.H. Shih;John Peacock;Livia Garzia

  • K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas.

    Dong Anh Khuong-Quang;Pawel Buczkowicz;Patricia Rakopoulos;Xiao Yang Liu

  • The whole-genome landscape of medulloblastoma subtypes

    Paul A. Northcott;Paul A. Northcott;Ivo Buchhalter;Ivo Buchhalter;A. Sorana Morrissy;Volker Hovestadt

  • New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

    Dominik Sturm;Dominik Sturm;Brent A. Orr;Umut H. Toprak;Volker Hovestadt

  • Dissecting the genomic complexity underlying medulloblastoma

    David T. W. Jones;Natalie Jäger;Marcel Kool;Thomas Zichner

  • Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

    Tobias Rausch;David T.W. Jones;Marc Zapatka;Adrian M. Stütz

  • The multidrug resistance protein family.

    Piet Borst;Raymond Evers;Marcel Kool;Jan Wijnholds

  • Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features

    Marcel Kool;Jan Koster;Jens Bunt;Nancy E. Hasselt

  • MRP3, an organic anion transporter able to transport anti-cancer drugs

    M. Kool;M. van der Linden;M. de Haas;G. L. Scheffer

Frequent Co-Authors

Stefan M. Pfister
Stefan M. Pfister German Cancer Research Center
Andrey Korshunov
Andrey Korshunov German Cancer Research Center
David T. W. Jones
David T. W. Jones German Cancer Research Center
Paul A. Northcott
Paul A. Northcott St. Jude Children's Research Hospital
Andreas von Deimling
Andreas von Deimling Heidelberg University
Michael D. Taylor
Michael D. Taylor University of Toronto
Peter Lichter
Peter Lichter German Cancer Research Center
David Capper
David Capper Charité - University Medicine Berlin
Marc Remke
Marc Remke German Cancer Research Center
Felix Sahm
Felix Sahm University Hospital Heidelberg

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