Paul A. Northcott mostly deals with Medulloblastoma, Bioinformatics, Genetics, Cancer research and Gene expression profiling. His studies deal with areas such as Cancer, SMARCA4, Li–Fraumeni syndrome, Survival rate and Genomics as well as Medulloblastoma. His Bioinformatics study combines topics in areas such as Disease, Gene, Human genetics and DNA methylation.
His study in Cancer research is interdisciplinary in nature, drawing from both Immunology, Sonic hedgehog, Signal transduction, Enhancer and Gene silencing. The Gene expression profiling study combines topics in areas such as Clinical trial, Transcriptome, Consensus conference, Adult Medulloblastoma and Molecular classification. He interconnects DNA Mutational Analysis, Cytidine deaminase, DNA mismatch repair and APOBEC, Kataegis in the investigation of issues within Exome.
His primary areas of investigation include Medulloblastoma, Cancer research, Cancer, Bioinformatics and Genetics. Paul A. Northcott combines subjects such as Wnt signaling pathway, Oncology, Genomics, Sonic hedgehog and Internal medicine with his study of Medulloblastoma. His research integrates issues of DNA methylation, Carcinogenesis, Mutation, Metastasis and Gene silencing in his study of Cancer research.
His study looks at the relationship between DNA methylation and topics such as Epigenetics, which overlap with Histone. His Cancer research is multidisciplinary, incorporating elements of Phenotype, Chromothripsis, Germline mutation and Human genetics. His Bioinformatics research focuses on Gene expression profiling and how it connects with Immunohistochemistry.
His primary scientific interests are in Medulloblastoma, Cancer research, Internal medicine, Oncology and Germline. His Medulloblastoma research integrates issues from Chemotherapy regimen, Wnt signaling pathway, Genomics, Sonic hedgehog and Computational biology. His Cancer research research incorporates elements of Carcinogenesis, Suppressor, Single-cell analysis, Circulating tumor DNA and In vivo.
Paul A. Northcott has researched Germline in several fields, including Cancer, Germline mutation, Knockout mouse and Somatic cell. His Cancer research is included under the broader classification of Genetics. His biological study spans a wide range of topics, including Exome sequencing, Multicenter study and Bioinformatics.
Paul A. Northcott spends much of his time researching Medulloblastoma, Cancer research, Computational biology, Germline and Sonic hedgehog. Paul A. Northcott integrates Medulloblastoma and In patient in his research. His studies in Cancer research integrate themes in fields like Transcriptome, Regulation of gene expression, In vivo and Single-cell analysis.
His Computational biology research incorporates themes from Genome, Whole genome sequencing, Meta-analysis, Concordance and Risk stratification. His Germline research includes themes of Germline mutation, Multicenter study, Bioinformatics and PTCH1. He has included themes like Ex vivo, Survival rate, Downregulation and upregulation, Receptor and Macrophage in his Sonic hedgehog study.
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Signatures of mutational processes in human cancer
Ludmil B. Alexandrov;Serena Nik-Zainal;Serena Nik-Zainal;David C. Wedge;Samuel A. J. R. Aparicio.
Molecular Subgroups of Medulloblastoma: The Current Consensus
Michael D. Taylor;Paul A. Northcott;Andrey Korshunov;Marc Remke;Marc Remke.
Acta Neuropathologica (2012)
DNA methylation-based classification of central nervous system tumours
David Capper;David Capper;David Capper;David T. W. Jones;Martin Sill;Volker Hovestadt.
Medulloblastoma Comprises Four Distinct Molecular Variants
Paul A. Northcott;Andrey Korshunov;Hendrik Witt;Thomas Hielscher.
Journal of Clinical Oncology (2011)
Pan-cancer analysis of whole genomes
Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart.
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas
Marcel Kool;Andrey Korshunov;Marc Remke;Marc Remke;David T.W. Jones.
Acta Neuropathologica (2012)
Dissecting the genomic complexity underlying medulloblastoma
David T. W. Jones;Natalie Jäger;Marcel Kool;Thomas Zichner.
The landscape of genomic alterations across childhood cancers
Susanne N. Gröbner;Barbara C. Worst;Joachim Weischenfeldt;Joachim Weischenfeldt;Ivo Buchhalter.
Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations
Tobias Rausch;David T.W. Jones;Marc Zapatka;Adrian M. Stütz.
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Paul A. Northcott;Paul A. Northcott;David J.H. Shih;John Peacock;Livia Garzia.
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