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Medicine

D-Index
98
Citations
62129
World Ranking
8732
National Ranking
4501

Overview

Paul A. Northcott is affiliated with St. Jude Children's Research Hospital in the United States. Their research focuses primarily on understanding molecular and genetic factors related to pediatric brain tumors, with an emphasis on medulloblastoma.

The scientist's notable recent publications include the following:

  • Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03), 2021, Journal of Clinical Oncology
  • Children's Oncology Group Phase III Trial of Reduced-Dose and Reduced-Volume Radiotherapy With Chemotherapy for Newly Diagnosed Average-Risk Medulloblastoma, 2021, Journal of Clinical Oncology
  • Germline Elongator mutations in Sonic Hedgehog medulloblastoma, 2020, Nature
  • Serial assessment of measurable residual disease in medulloblastoma liquid biopsies, 2021, Cancer Cell
  • Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma, 2021, JAMA Oncology

Frequent collaborators of Paul A. Northcott include Giles Robinson, Amar Gajjar, Brent A. Orr, Kyle Smith, and Brian Gudenas. These coauthors have contributed extensively to research in areas overlapping with Northcott's work.

The scientist often publishes in these venues:

  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Acta Neuropathologica
  • Journal of Clinical Oncology

Research fields associated with Paul A. Northcott primarily span biochemistry, genetics, and molecular biology, with a substantial number of publications in medicine as well.

Subfields that are prominent in their work include:

  • Molecular Biology
  • Genetics
  • Cancer Research
  • Pulmonary and Respiratory Medicine
  • Neurology

Main topics addressed in their research cover a range of cancer and genomic areas:

  • Glioma Diagnosis and Treatment
  • Hedgehog Signaling Pathway Studies
  • Cancer Genomics and Diagnostics
  • Single-cell and spatial transcriptomics
  • Cancer-related molecular mechanisms research
  • Genomics and Chromatin Dynamics
  • Chromatin Remodeling and Cancer

Best Publications

  • Signatures of mutational processes in human cancer

    Ludmil B. Alexandrov;Serena Nik-Zainal;Serena Nik-Zainal;David C. Wedge;Samuel A. J. R. Aparicio

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • DNA methylation-based classification of central nervous system tumours

    David Capper;David Capper;David Capper;David T. W. Jones;Martin Sill;Volker Hovestadt

  • Molecular Subgroups of Medulloblastoma: The Current Consensus

    Michael D. Taylor;Paul A. Northcott;Andrey Korshunov;Marc Remke;Marc Remke

  • The landscape of genomic alterations across childhood cancers

    Susanne N. Gröbner;Barbara C. Worst;Joachim Weischenfeldt;Joachim Weischenfeldt;Ivo Buchhalter

  • Medulloblastoma Comprises Four Distinct Molecular Variants

    Paul A. Northcott;Andrey Korshunov;Hendrik Witt;Thomas Hielscher

  • Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

    Marcel Kool;Andrey Korshunov;Marc Remke;Marc Remke;David T.W. Jones

  • Subgroup-specific structural variation across 1,000 medulloblastoma genomes

    Paul A. Northcott;Paul A. Northcott;David J.H. Shih;John Peacock;Livia Garzia

  • The whole-genome landscape of medulloblastoma subtypes

    Paul A. Northcott;Paul A. Northcott;Ivo Buchhalter;Ivo Buchhalter;A. Sorana Morrissy;Volker Hovestadt

  • New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

    Dominik Sturm;Dominik Sturm;Brent A. Orr;Umut H. Toprak;Volker Hovestadt

  • Patterns of somatic structural variation in human cancer genomes

    Yilong Li;Nicola D Roberts;Jeremiah A Wala;Jeremiah A Wala;Ofer Shapira;Ofer Shapira

  • Dissecting the genomic complexity underlying medulloblastoma

    David T. W. Jones;Natalie Jäger;Marcel Kool;Thomas Zichner

  • Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

    Tobias Rausch;David T.W. Jones;Marc Zapatka;Adrian M. Stütz

  • Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas

    Sebastian Bender;Sebastian Bender;Yujie Tang;Anders M. Lindroth;Volker Hovestadt

  • Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

    Trevor J Pugh;Trevor J Pugh;Shyamal Dilhan Weeraratne;Shyamal Dilhan Weeraratne;Tenley C. Archer;Tenley C. Archer;Daniel A. Pomeranz Krummel

  • Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

    David T W Jones;Barbara Hutter;Natalie Jäger;Andrey Korshunov;Andrey Korshunov

  • The Genetic Landscape of the Childhood Cancer Medulloblastoma

    D. Williams Parsons;D. Williams Parsons;Meng Li;Xiaosong Zhang;Siân Jones

  • Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

    Marcel Kool;David T.W. Jones;Natalie Jäger;Paul A. Northcott

  • Medulloblastomics: the end of the beginning

    Paul A. Northcott;David T.W. Jones;Marcel Kool;Giles W. Robinson

  • Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

    Paul A. Northcott;Catherine Lee;Catherine Lee;Thomas Zichner;Adrian M. Stütz

Frequent Co-Authors

Stefan M. Pfister
Stefan M. Pfister German Cancer Research Center
Michael D. Taylor
Michael D. Taylor University of Toronto
Andrey Korshunov
Andrey Korshunov German Cancer Research Center
Marcel Kool
Marcel Kool German Cancer Research Center
David T. W. Jones
David T. W. Jones German Cancer Research Center
Peter Lichter
Peter Lichter German Cancer Research Center
Marc Remke
Marc Remke German Cancer Research Center
Amar Gajjar
Amar Gajjar St. Jude Children's Research Hospital
Andreas von Deimling
Andreas von Deimling Heidelberg University
James T. Rutka
James T. Rutka University of Toronto

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