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Medicine

D-Index
101
Citations
45186
World Ranking
7870
National Ranking
446

Overview

David Capper is affiliated with Charité - University Medicine Berlin in Germany. Their research spans extensive work in the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a specific focus on Genetics, Molecular Biology, Cancer Research, Neurology, and Pulmonary and Respiratory Medicine.

The primary research topics addressed by David Capper include:

  • Glioma Diagnosis and Treatment
  • Meningioma and schwannoma management
  • Epigenetics and DNA Methylation
  • Cancer Genomics and Diagnostics
  • Brain Metastases and Treatment
  • Neuroblastoma Research and Treatments
  • Cancer-related molecular mechanisms research

They have contributed to numerous publications across various scientific venues. Frequent publication platforms for their work include:

  • Neuro-Oncology
  • Acta Neuropathologica
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Neuro-Oncology
  • Neuro-Oncology Advances

David Capper has collaborated extensively with several co-authors, including Felix Sahm, Andreas von Deimling, Stefan M. Pfister, David Jones, and Ulrich Schüller.

Selected recent publications highlighting themes within their research are:

  • cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading, 2020, Brain Pathology
  • Primary brain tumours in adults, 2023, The Lancet
  • cIMPACT-NOW update 7: advancing the molecular classification of ependymal tumors, 2020, Brain Pathology
  • The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets, 2021, Cancer Discovery
  • Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data, 2020, Nature Protocols

Best Publications

  • DNA methylation-based classification of central nervous system tumours

    David Capper;David Capper;David Capper;David T. W. Jones;Martin Sill;Volker Hovestadt

  • A complex secretory program orchestrated by the inflammasome controls paracrine senescence

    Juan Carlos Acosta;Ana Banito;Torsten Wuestefeld;Athena Georgilis

  • Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

    Genevieve Schindler;David Capper;David Capper;Jochen Meyer;Wibke Janzarik

  • Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

    Christian Hartmann;Christian Hartmann;Jochen Meyer;Jörg Balss;David Capper

  • Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

    Kristian W. Pajtler;Kristian W. Pajtler;Hendrik Witt;Martin Sill;David T.W. Jones

  • Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: Implications for classification of gliomas

    Christian Hartmann;Christian Hartmann;Bettina Hentschel;Wolfgang Wick;Wolfgang Wick;David Capper

  • The whole-genome landscape of medulloblastoma subtypes

    Paul A. Northcott;Paul A. Northcott;Ivo Buchhalter;Ivo Buchhalter;A. Sorana Morrissy;Volker Hovestadt

  • New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

    Dominik Sturm;Dominik Sturm;Brent A. Orr;Umut H. Toprak;Volker Hovestadt

  • Actively personalized vaccination trial for newly diagnosed glioblastoma

    Norbert Hilf;Sabrina Kuttruff-Coqui;Katrin Frenzel;Valesca Bukur

  • WHO 2016 Classification of gliomas

    Pieter Wesseling;Pieter Wesseling;David Capper;David Capper;David Capper

  • DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

    Felix Sahm;Felix Sahm;Daniel Schrimpf;Damian Stichel;David T.W. Jones

  • Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors.

    David Capper;Susanne Weißert;Jörg Balss;Antje Habel

  • ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma.

    David E. Reuss;Felix Sahm;Felix Sahm;Daniel Schrimpf;Daniel Schrimpf;Benedikt Wiestler;Benedikt Wiestler

  • Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody

    David Capper;David Capper;Matthias Preusser;Matthias Preusser;Antje Habel;Felix Sahm;Felix Sahm

  • Monoclonal antibody specific for IDH1 R132H mutation.

    David Capper;Hanswalter Zentgraf;Jörg Balss;Christian Hartmann;Christian Hartmann

  • Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

    Pascal D. Johann;Pascal D. Johann;Serap Erkek;Marc Zapatka;Kornelius Kerl

  • Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study

    Brigitta G Baumert;Brigitta G Baumert;Monika E Hegi;Martin J van den Bent;Andreas von Deimling

  • cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading.

    David N. Louis;Pieter Wesseling;Kenneth Aldape;Daniel J. Brat

  • Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience

    David Capper;Damian Stichel;Damian Stichel;Felix Sahm;Felix Sahm;David T. W. Jones

  • ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis

    Benedikt Wiestler;David Capper;David Capper;Tim Holland-Letz;Andrey Korshunov;Andrey Korshunov

Frequent Co-Authors

Andreas von Deimling
Andreas von Deimling Heidelberg University
Stefan M. Pfister
Stefan M. Pfister German Cancer Research Center
Felix Sahm
Felix Sahm University Hospital Heidelberg
David T. W. Jones
David T. W. Jones German Cancer Research Center
Andrey Korshunov
Andrey Korshunov German Cancer Research Center
Wolfgang Wick
Wolfgang Wick German Cancer Research Center
Christian Hartmann
Christian Hartmann Hannover Medical School
Christel Herold-Mende
Christel Herold-Mende Heidelberg University
Marcel Kool
Marcel Kool German Cancer Research Center
Michael Weller
Michael Weller University of Zurich

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