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Medicine

D-Index
118
Citations
55933
World Ranking
4038
National Ranking
2213

Overview

Keith L. Ligon is affiliated with Harvard University in the United States. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, contributing extensively to understanding cancer biology and related areas.

The main topics covered in their work include:

  • Glioma Diagnosis and Treatment
  • Cancer Genomics and Diagnostics
  • Radiomics and Machine Learning in Medical Imaging
  • Neuroblastoma Research and Treatments
  • Single-cell and Spatial Transcriptomics
  • Cancer, Hypoxia, and Metabolism
  • Cancer Research and Treatments

Ligon has published in notable venues, with frequent contributions to:

  • Neuro-Oncology
  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Neuro-Oncology Advances

Among their recent scientific papers are:

  • Mechanisms and therapeutic implications of hypermutation in gliomas, 2020, Nature
  • Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis, 2021, Cell
  • A pathology foundation model for cancer diagnosis and prognosis prediction, 2024, Nature
  • A molecularly integrated grade for meningioma, 2021, Neuro-Oncology
  • Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions, 2022, Neuro-Oncology

Their collaborative work frequently involves co-authors such as:

  • Patrick Y. Wen
  • Pratiti Bandopadhayay
  • Rameen Beroukhim
  • David A. Reardon
  • Wenya Linda Bi

Ligon's research emphasizes genetic and molecular mechanisms underpinning cancer, especially gliomas and other brain tumors. Their involvement in molecular biology and genetics is reflected in a substantial number of publications addressing cancer genomics and diagnostics.

Their contributions include investigations using advanced methodologies such as single-cell transcriptomics and machine learning in medical imaging, reflecting interdisciplinary approaches linking molecular biology with computational techniques.

Best Publications

  • Malignant astrocytic glioma: genetics, biology, and paths to treatment.

    Frank B. Furnari;Tim Fenton;Robert M. Bachoo;Akitake Mukasa

  • An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

    Cyril Neftel;Julie Laffy;Mariella G. Filbin;Toshiro Hara

  • Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

    Derin B. Keskin;Annabelle J. Anandappa;Jing Sun;Itay Tirosh

  • Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies

    Jayne M. Stommel;Alec C. Kimmelman;Haoqiang Ying;Roustem Nabioullin

  • p16INK4a induces an age-dependent decline in islet regenerative potential.

    Janakiraman Krishnamurthy;Matthew R. Ramsey;Keith L. Ligon;Chad Torrice

  • Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

    Priscilla K. Brastianos;Scott L. Carter;Scott L. Carter;Sandro Santagata;Sandro Santagata;Daniel P. Cahill

  • p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

    Hongwu Zheng;Haoqiang Ying;Haiyan Yan;Alec C. Kimmelman

  • Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.

    Robert M Bachoo;Elizabeth A Maher;Keith L Ligon;Norman E Sharpless

  • Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

    David T W Jones;Barbara Hutter;Natalie Jäger;Andrey Korshunov;Andrey Korshunov

  • Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.

    Yoon Jae Cho;Aviad Tsherniak;Pablo Tamayo;Sandro Santagata

  • Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.

    Ulrich Schüller;Vivi M. Heine;Vivi M. Heine;Junhao Mao;Alvin T. Kho

  • Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

    Mariella G. Filbin;Itay Tirosh;Itay Tirosh;Volker Hovestadt;Volker Hovestadt;McKenzie L. Shaw;McKenzie L. Shaw

  • Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations

    Priscilla K Brastianos;Peleg M Horowitz;Sandro Santagata;Sandro Santagata;Robert T Jones

  • Emerging insights into the molecular and cellular basis of glioblastoma

    Gavin P. Dunn;Mikael L. Rinne;Mikael L. Rinne;Jill Wykosky;Giannicola Genovese

  • Mechanisms and therapeutic implications of hypermutation in gliomas.

    Mehdi Touat;Mehdi Touat;Mehdi Touat;Yvonne Y. Li;Yvonne Y. Li;Adam N. Boynton;Adam N. Boynton;Liam F. Spurr;Liam F. Spurr

  • Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination

    Ben Emery;Dritan Agalliu;John D. Cahoy;Trent A. Watkins

  • Targetable genetic features of primary testicular and primary central nervous system lymphomas

    Bjoern Chapuy;Margaretha G. M. Roemer;Margaretha G. M. Roemer;Chip Stewart;Yuxiang Tan

  • Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.

    Keith L. Ligon;Emmanuelle Huillard;Emmanuelle Huillard;Shwetal Mehta;Santosh Kesari

  • Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

    Nicholas Butowski;Howard Colman;John F. De Groot;Antonio M. Omuro

  • Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell-derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity.

    Jessian L Munoz;Sarah A Bliss;Steven J Greco;Shakti H Ramkissoon;Shakti H Ramkissoon

Frequent Co-Authors

Rameen Beroukhim
Rameen Beroukhim Harvard University
Patrick Y. Wen
Patrick Y. Wen Harvard University
David A. Reardon
David A. Reardon Harvard University
Sandro Santagata
Sandro Santagata Brigham and Women's Hospital
Mark W. Kieran
Mark W. Kieran Harvard University
Brian M. Alexander
Brian M. Alexander Foundation Medicine
Azra H. Ligon
Azra H. Ligon Brigham and Women's Hospital
William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Tracy T. Batchelor
Tracy T. Batchelor Brigham and Women's Hospital
E. Antonio Chiocca
E. Antonio Chiocca Brigham and Women's Hospital

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