D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 98 Citations 36,999 449 World Ranking 5344 National Ranking 2962

Overview

What is he best known for?

The fields of study he is best known for:

  • Cancer
  • Gene
  • Internal medicine

The scientist’s investigation covers issues in Cancer research, Glioma, Bioinformatics, Mutation and Pathology. His biological study spans a wide range of topics, including Carcinogenesis, Cancer, Immunology, microRNA and PI3K/AKT/mTOR pathway. His work in the fields of Glioma, such as Astrocytoma, overlaps with other areas such as Macrophage colony-stimulating factor.

The study incorporates disciplines such as Immunohistochemistry, Gene expression profiling, Genomics, Exome and Disease in addition to Bioinformatics. His studies deal with areas such as AKT1, Histone H3, Epigenetics and Somatic cell as well as Mutation. Keith L. Ligon focuses mostly in the field of Pathology, narrowing it down to topics relating to Oligodendrocyte and, in certain cases, Embryonic stem cell and Gene expression.

His most cited work include:

  • Malignant astrocytic glioma: genetics, biology, and paths to treatment (1780 citations)
  • p16INK4a induces an age-dependent decline in islet regenerative potential. (800 citations)
  • Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies (796 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Cancer research, Glioma, Internal medicine, Pathology and Oncology. The Cancer research study combines topics in areas such as Cell and Carcinogenesis, Cancer, Gene, Mutation. His Glioma research is multidisciplinary, incorporating elements of Phenotype, IDH1 and Bioinformatics.

Keith L. Ligon has included themes like Surgery and Glioblastoma in his Internal medicine study. His research integrates issues of Exome sequencing, Magnetic resonance imaging, Oligodendroglioma and PTEN in his study of Pathology. His Oncology research includes themes of Bevacizumab and Clinical endpoint.

He most often published in these fields:

  • Cancer research (56.11%)
  • Glioma (32.44%)
  • Internal medicine (29.96%)

What were the highlights of his more recent work (between 2019-2021)?

  • Cancer research (56.11%)
  • Oncology (27.29%)
  • Internal medicine (29.96%)

In recent papers he was focusing on the following fields of study:

Cancer research, Oncology, Internal medicine, Glioma and Glioblastoma are his primary areas of study. His studies in Cancer research integrate themes in fields like Mutation, Cell, Cancer and Gene knockdown. His Cell research incorporates themes from Cellular differentiation, RNA, Cancer stem cell, Transcriptome and Ependymoma.

His research investigates the connection between Cancer and topics such as Temozolomide that intersect with issues in Precision medicine and DNA mismatch repair. His work deals with themes such as O-6-methylguanine-DNA methyltransferase, Phases of clinical research, Lymphocyte and Immunotherapy, which intersect with Oncology. He interconnects Mutant, PTEN and Pathology in the investigation of issues within Glioma.

Between 2019 and 2021, his most popular works were:

  • Mechanisms and therapeutic implications of hypermutation in gliomas. (83 citations)
  • A large peptidome dataset improves HLA class I epitope prediction across most of the human population. (77 citations)
  • Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma. (16 citations)

In his most recent research, the most cited papers focused on:

  • Cancer
  • Gene
  • Internal medicine

Keith L. Ligon focuses on Cancer research, Oncology, Internal medicine, Computational biology and RNA. His Cancer research research focuses on Glioma in particular. The concepts of his Glioma study are interwoven with issues in Gene expression, PTEN, Single-cell analysis, Receptor and Buparlisib.

His Oncology research includes elements of Immune checkpoint, Corticosteroid, Myeloid and Lymphocyte. His work on Dexamethasone, Blockade, Immunotherapy and Biopsy as part of general Internal medicine study is frequently linked to Context, bridging the gap between disciplines. As a member of one scientific family, Keith L. Ligon mostly works in the field of Computational biology, focusing on Cellular differentiation and, on occasion, Cell.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Malignant astrocytic glioma: genetics, biology, and paths to treatment.

Frank B. Furnari;Tim Fenton;Robert M. Bachoo;Akitake Mukasa.
Genes & Development (2007)

2676 Citations

Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies

Jayne M. Stommel;Alec C. Kimmelman;Haoqiang Ying;Roustem Nabioullin.
Science (2007)

1049 Citations

p16INK4a induces an age-dependent decline in islet regenerative potential.

Janakiraman Krishnamurthy;Matthew R. Ramsey;Keith L. Ligon;Chad Torrice.
Nature (2006)

1032 Citations

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

Cyril Neftel;Julie Laffy;Mariella G. Filbin;Toshiro Hara.
Cell (2019)

894 Citations

Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.

Robert M Bachoo;Elizabeth A Maher;Keith L Ligon;Norman E Sharpless.
Cancer Cell (2002)

808 Citations

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

Hongwu Zheng;Haoqiang Ying;Haiyan Yan;Alec C. Kimmelman.
Nature (2008)

789 Citations

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

Derin B. Keskin;Annabelle J. Anandappa;Jing Sun;Itay Tirosh.
Nature (2019)

767 Citations

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

Priscilla K. Brastianos;Scott L. Carter;Scott L. Carter;Sandro Santagata;Sandro Santagata;Daniel P. Cahill.
Cancer Discovery (2015)

737 Citations

Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.

Yoon Jae Cho;Aviad Tsherniak;Pablo Tamayo;Sandro Santagata.
Journal of Clinical Oncology (2011)

725 Citations

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

David T W Jones;Barbara Hutter;Natalie Jäger;Andrey Korshunov;Andrey Korshunov.
Nature Genetics (2013)

699 Citations

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