World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
94
Citations
35378
World Ranking
10420
National Ranking
5365

Overview

Sandro Santagata is affiliated with Brigham and Women's Hospital in the United States. Their research activity spans multiple disciplines, primarily focused on medicine and biochemistry, genetics, and molecular biology. The subfields of their work include molecular biology, oncology, genetics, biophysics, and epidemiology.

The scientist has contributed extensively to areas including glioma diagnosis and treatment, single-cell and spatial transcriptomics, cell image analysis techniques, meningioma and schwannoma management, cancer genomics and diagnostics, cancer immunotherapy and biomarkers, and immunotherapy and immune responses.

Recent notable publications by Santagata include:

  • Copper induces cell death by targeting lipoylated TCA cycle proteins, 2022, Science
  • Mechanisms and therapeutic implications of hypermutation in gliomas, 2020, Nature
  • The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution, 2020, Cell
  • Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer, 2020, Nature Communications
  • Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma, 2020, Nature Genetics

Santagata frequently collaborates with researchers such as:

  • Peter K. Sorger
  • Jia-Ren Lin
  • Keith L. Ligon
  • Clarence Yapp
  • Shannon Coy

Their research has appeared in prominent publication venues, including:

  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature Communications
  • Journal of Clinical Oncology

Best Publications

  • Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

    Priscilla K. Brastianos;Scott L. Carter;Scott L. Carter;Sandro Santagata;Sandro Santagata;Daniel P. Cahill

  • Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.

    Yoon Jae Cho;Aviad Tsherniak;Pablo Tamayo;Sandro Santagata

  • HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

    Marc L. Mendillo;Sandro Santagata;Sandro Santagata;Martina Koeva;George W. Bell

  • Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations

    Priscilla K Brastianos;Peleg M Horowitz;Sandro Santagata;Sandro Santagata;Robert T Jones

  • Mechanisms and therapeutic implications of hypermutation in gliomas.

    Mehdi Touat;Mehdi Touat;Mehdi Touat;Yvonne Y. Li;Yvonne Y. Li;Adam N. Boynton;Adam N. Boynton;Liam F. Spurr;Liam F. Spurr

  • Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes

    Jia-Ren Lin;Benjamin Izar;Shu Wang;Clarence Yapp

  • Mitochondrial metabolism promotes adaptation to proteotoxic stress.

    Peter Tsvetkov;Alexandre Detappe;Kai Cai;Heather R Keys

  • The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution

    Orit Rozenblatt-Rosen;Aviv Regev;Aviv Regev;Aviv Regev;Philipp Oberdoerffer;Tal Nawy

  • Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy.

    Minbiao Ji;Daniel A. Orringer;Christian W. Freudiger;Shakti Ramkissoon;Shakti Ramkissoon

  • A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas

    Patricia L. M. Dahia;Ken N Ross;Matthew E Wright;Cesar Y. Hayashida

  • Partial V(D)J Recombination Activity Leads to Omenn Syndrome

    Anna Villa;Sandro Santagata;Fabio Bozzi;Silvia Giliani

  • Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations

    Christopher J. Lengner;Alexander A. Gimelbrant;Jennifer A. Erwin;Jennifer A. Erwin;Albert Wu Cheng

  • Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas

    Priscilla K Brastianos;Amaro Taylor-Weiner;Peter E Manley;Robert T Jones

  • JAGGED1 expression is associated with prostate cancer metastasis and recurrence

    Sandro Santagata;Francesca Demichelis;Alberto Riva;Sooryanarayana Varambally

  • Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples

    Laura E. MacConaill;Catarina D. Campbell;Sarah M. Kehoe;Adam J. Bass

  • V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations.

    Anna Villa;Cristina Sobacchi;Luigi D. Notarangelo;Fabio Bozzi

  • The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

    Ruth Scherz-Shouval;Sandro Santagata;Sandro Santagata;Sandro Santagata;Marc L. Mendillo;Lynette Marie Sholl

  • Classifying human brain tumors by lipid imaging with mass spectrometry

    Livia S. Eberlin;Isaiah Norton;Allison L. Dill;Alexandra J. Golby

  • High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer

    Sandro Santagata;Rong Hu;Nancy U. Lin;Marc L. Mendillo

  • BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications.

    Dora Dias-Santagata;Quynh Lam;Kathy Vernovsky;Natalie Vena

Frequent Co-Authors

Keith L. Ligon
Keith L. Ligon Harvard University
Rameen Beroukhim
Rameen Beroukhim Harvard University
Peter K. Sorger
Peter K. Sorger Harvard University
Patrick Y. Wen
Patrick Y. Wen Harvard University
Brian M. Alexander
Brian M. Alexander Foundation Medicine
Azra H. Ligon
Azra H. Ligon Brigham and Women's Hospital
David A. Reardon
David A. Reardon Harvard University
Tracy T. Batchelor
Tracy T. Batchelor Brigham and Women's Hospital
Mark W. Kieran
Mark W. Kieran Harvard University

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