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Medicine

D-Index
96
Citations
31781
World Ranking
9730
National Ranking
5007

Overview

E. Antonio Chiocca is affiliated with Brigham and Women's Hospital in the United States. Their scholarly work spans multiple areas mainly within medicine, biochemistry, genetics, and molecular biology. Chiocca has a substantial research footprint in genetics, oncology, molecular biology, immunology, and cancer research, reflected in a diverse range of published studies.

Their research topics primarily focus on glioma diagnosis and treatment, virus-based gene therapy, CAR-T cell therapy, cancer research and treatments, cancer immunotherapy and biomarkers, cancer genomics and diagnostics, and viral infectious diseases and gene expression in insects.

Chiocca's recent notable papers include:

  • Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions, 2020, Neuro-Oncology
  • Mechanisms and therapeutic implications of hypermutation in gliomas, 2020, Nature
  • Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis, 2021, Cell
  • Advances in local therapy for glioblastoma - taking the fight to the tumour, 2022, Nature Reviews Neurology
  • The emerging field of oncolytic virus-based cancer immunotherapy, 2022, Trends in cancer

They frequently collaborate with several researchers, including:

  • David A. Reardon
  • Keith L. Ligon
  • Patrick Y. Wen
  • Wenya Linda Bi
  • Hiroshi Nakashima

Chiocca often publishes in the following venues, indicating a concentration in neuro-oncology and clinical oncology domains:

  • Neuro-Oncology
  • Journal of Clinical Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Journal of neurosurgery

Their scientific contributions primarily inhabit the intersection of molecular biology and cancer therapy, particularly targeting gliomas through therapeutic approaches that include gene therapy and immunotherapy modalities. This body of work reflects an integration of clinical oncology with molecular and genetic research techniques.

Best Publications

  • Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

    Derin B. Keskin;Annabelle J. Anandappa;Jing Sun;Itay Tirosh

  • In vivo magnetic resonance imaging of transgene expression.

    Ralph Weissleder;Anna Moore;Umar Mahmood;Rajeev Bhorade

  • microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

    Benjamin Kefas;Jakub Godlewski;Laurey Comeau;Yunqing Li

  • Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal

    Jakub Godlewski;Michal O. Nowicki;Agnieszka Bronisz;Shanté Williams

  • Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

    Patrick Y. Wen;Michael Weller;Eudocia Quant Lee;Brian M. Alexander

  • Mechanisms and therapeutic implications of hypermutation in gliomas.

    Mehdi Touat;Mehdi Touat;Mehdi Touat;Yvonne Y. Li;Yvonne Y. Li;Adam N. Boynton;Adam N. Boynton;Liam F. Spurr;Liam F. Spurr

  • Glial Tumor Grading and Outcome Prediction Using Dynamic Spin-Echo MR Susceptibility Mapping Compared with Conventional Contrast-Enhanced MR: Confounding Effect of Elevated rCBV of Oligodendroglimoas

    Michael H. Lev;Yelda Ozsunar;Yelda Ozsunar;John W. Henson;Amjad A. Rasheed

  • A Phase I Open-Label, Dose-Escalation, Multi-Institutional Trial of Injection with an E1B-Attenuated Adenovirus, ONYX-015, into the Peritumoral Region of Recurrent Malignant Gliomas, in the Adjuvant Setting

    E. Antonio Chiocca;Khalid M. Abbed;Stephen Tatter;David N. Louis

  • Oncolytic Viruses in Cancer Treatment: A Review

    Sean E. Lawler;Maria Carmela Speranza;Choi Fong Cho;E. Antonio Chiocca

  • Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

    Franz L. Ricklefs;Franz L. Ricklefs;Quazim Alayo;Harald Krenzlin;Ahmad B. Mahmoud;Ahmad B. Mahmoud

  • MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells.

    Jakub Godlewski;Michal O. Nowicki;Agnieszka Bronisz;Gerard Nuovo

  • Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses.

    Giulia Fulci;Laura Breymann;Davide Gianni;Kazuhiko Kurozomi

  • Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses

    Keiro Ikeda;Tomotsugu Ichikawa;Hiroaki Wakimoto;Jonathan S. Silver

  • Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

    Nathan D. Mathewson;Orr Ashenberg;Itay Tirosh;Simon Gritsch;Simon Gritsch

  • CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells.

    Jianfeng Han;Jianhong Chu;Wing Keung Chan;Jianying Zhang

  • Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320

    A. Bronisz;J. Godlewski;J. A. Wallace;A.S. Merchant

  • An Oncolytic HSV-1 Mutant Expressing ICP34.5 under Control of a Nestin Promoter Increases Survival of Animals even when Symptomatic from a Brain Tumor

    Hirokazu Kambara;Hideyuki Okano;E. Antonio Chiocca;Yoshinaga Saeki

  • Multiplexed Profiling of Single Extracellular Vesicles.

    Kyungheon Lee;Kyle Fraser;Bassel Ghaddar;Katy Yang

  • Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease.

    Marielle Ousset;Fanny Bouquet;Frédérique Fallone;Denis Biard

  • Improved Helper Virus-Free Packaging System for HSV Amplicon Vectors Using an ICP27-Deleted, Oversized HSV-1 DNA in a Bacterial Artificial Chromosome

    Yoshinaga Saeki;Yoshinaga Saeki;Cornel Fraefel;Tomotsugu Ichikawa;Xandra O Breakefield

Frequent Co-Authors

Sean E. Lawler
Sean E. Lawler Brown University
Balveen Kaur
Balveen Kaur Augusta University
David A. Reardon
David A. Reardon Harvard University
Keith L. Ligon
Keith L. Ligon Harvard University
Patrick Y. Wen
Patrick Y. Wen Harvard University
Xandra O. Breakefield
Xandra O. Breakefield Harvard University
Ichiro Nakano
Ichiro Nakano University of Alabama at Birmingham
Ralph Weissleder
Ralph Weissleder Harvard University
Rameen Beroukhim
Rameen Beroukhim Harvard University
Brian M. Alexander
Brian M. Alexander Foundation Medicine

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