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Richard G. Vile

Richard G. Vile

D-Index & Metrics

Microbiology

D-Index
90
Citations
23819
World Ranking
701
National Ranking
325

Medicine

D-Index
91
Citations
24276
World Ranking
11928
National Ranking
6118

Overview

Richard G. Vile is affiliated with the Mayo Clinic in the United States. Their research work primarily spans across the fields of Biochemistry, Genetics and Molecular Biology; Medicine; and Immunology and Microbiology. Within these principal fields of study, several subfields are prominently represented, including Genetics, Immunology, Oncology, Molecular Biology, and Infectious Diseases.

The main topics of Richard G. Vile's research include virus-based gene therapy, CAR-T cell therapy, immunotherapy and immune responses, viral infectious diseases and gene expression in insects, cancer research and treatments, interferon and immune responses, as well as immune cell function and interaction.

Among their recent publications are:

  • "Oncolytic virus-mediated expansion of dual-specific CAR T cells improves efficacy against solid tumors in mice," 2022, Science Translational Medicine
  • "Oncolytic virotherapy as immunotherapy," 2021, Science
  • "Oncolytic virus-derived type I interferon restricts CAR T cell therapy," 2020, Nature Communications
  • "Brain cancer induces systemic immunosuppression through release of non-steroid soluble mediators," 2020, Brain
  • "APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy," 2020, Nature Communications

Frequent co-authors in their research include Alan Melcher, Laura Evgin, Jason M. Tonne, Jill Thompson, and Kevin J. Harrington.

Their research has been published regularly in several venues, notably:

  • Nature Communications
  • The Journal of Immunology
  • Molecular Therapy - Oncolytics
  • Neuro-Oncology
  • Journal for ImmunoTherapy of Cancer

Best Publications

  • Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes.

    Kevin J. Harrington;Kevin J. Harrington;Sima Mohammadtaghi;Paul S. Uster;Daphne Glass

  • Diverse Origin and Function of Cells With Endothelial Phenotype Obtained From Adult Human Blood

    Rajiv Gulati;Dragan Jevremovic;Timothy E. Peterson;Suvro Chatterjee

  • Classification of current anticancer immunotherapies

    Lorenzo Galluzzi;Erika Vacchelli;José Manuel Bravo-San Pedro;Aitziber Buqué

  • Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression

    Alan Melcher;Stephen Todryk;Nicola Hardwick;Martin Ford

  • Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake.

    Stephen Todryk;Alan A. Melcher;Alan A. Melcher;Nicola Hardwick;Emmanouela Linardakis

  • Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade

    Adel Samson;Karen J. Scott;David Taggart;Emma J. West

  • Use of Tissue-specific Expression of the Herpes Simplex Virus Thymidine Kinase Gene to Inhibit Growth of Established Murine Melanomas following Direct Intratumoral Injection of DNA

    Richard G. Vile;Ian R. Hart

  • Oncolytic immunovirotherapy for melanoma using vesicular stomatitis virus.

    Rosa Maria Diaz;Feorillo Galivo;Timothy Kottke;Phonphimon Wongthida

  • Cancer gene therapy: hard lessons and new courses.

    R G Vile;S J Russell;N R Lemoine

  • In Vitro and in Vivo Targeting of Gene Expression to Melanoma Cells

    Richard G. Vile;Ian R. Hart

  • A phase I study of intravenous oncolytic reovirus type 3 Dearing in patients with advanced cancer.

    Laura Vidal;Hardev S. Pandha;Timothy A. Yap;Christine L. White

  • Live attenuated measles virus induces regression of human lymphoma xenografts in immunodeficient mice.

    Deanna Grote;Stephen J. Russell;Stephen J. Russell;Tatjana I. Cornu;Tatjana I. Cornu;Roberto Cattaneo;Roberto Cattaneo

  • Generation of an anti‐tumour immune response in a non‐immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1‐like profile of intratumoural cytokine expression

    Richard G. Vile;Simon Castleden;John Marshall;Richard Camplejohn

  • The Case of Oncolytic Viruses Versus the Immune System: Waiting on the Judgment of Solomon

    Robin J. Prestwich;Fiona Errington;Rosa M. Diaz;Hardev S. Pandha

  • Immune-Mediated Antitumor Activity of Reovirus Is Required for Therapy and Is Independent of Direct Viral Oncolysis and Replication

    Robin J. Prestwich;Elizabeth J. Ilett;Fiona Errington;Rosa M. Diaz

  • Reovirus Activates Human Dendritic Cells to Promote Innate Antitumor Immunity

    Fiona Errington;Lynette Steele;Robin Prestwich;Kevin J. Harrington

  • Phase I-II study of pegylated liposomal cisplatin (SPI-077) in patients with inoperable head and neck cancer.

    Kevin J Harrington;C R Lewanski;A D Northcote;J Whittaker

  • Oncolytic viruses: a novel form of immunotherapy

    Robin J.D. Prestwich;Kevin J. Harrington;Hardev S. Pandha;Richard G. Vile

  • Tumor Infection by Oncolytic Reovirus Primes Adaptive Antitumor Immunity

    Robin J. Prestwich;Fiona Errington;Elizabeth J. Ilett;Ruth S.M. Morgan

  • Autologous Culture-Modified Mononuclear Cells Confer Vascular Protection After Arterial Injury

    Rajiv Gulati;Dragan Jevremovic;Timothy E. Peterson;Tyra A. Witt

  • Strategies for antigen loading of dendritic cells to enhance the antitumor immune response.

    Scott E. Strome;Stephen Voss;Ryan Wilcox;Tamekia L. Wakefield

Frequent Co-Authors

Alan Melcher
Alan Melcher Institute of Cancer Research
Kevin J. Harrington
Kevin J. Harrington Royal Marsden NHS Foundation Trust
Timothy Kottke
Timothy Kottke Mayo Clinic
Peter Selby
Peter Selby University of Leeds
Matthew C. Coffey
Matthew C. Coffey Oncolytics Biotech (Canada)
Michael J. Gough
Michael J. Gough Providence Portland Medical Center
Atique U. Ahmed
Atique U. Ahmed Northwestern University
Glen N. Barber
Glen N. Barber University of Miami
Stephen Todryk
Stephen Todryk Northumbria University

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