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Microbiology

D-Index
100
Citations
44692
World Ranking
398
National Ranking
186

Overview

Glen N. Barber is affiliated with the University of Miami in the United States. Their research primarily spans the fields of immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology. Within these fields, their subfield expertise includes immunology, molecular biology, infectious diseases, epidemiology, and small animals.

The main topics covered in Glen N. Barber's work focus heavily on interferon and immune responses, viral infections and vectors, inflammasome and immune disorders, ubiquitin and proteasome pathways, immune response and inflammation, herpesvirus infections and treatments, and cytomegalovirus and herpesvirus research.

Frequent coauthors in Barber's research include Rana Falahat, Anders Berglund, Shari Pilon-Thomas, James J. Mulé, and Patricio Perez-Villarroel. The collaboration with these researchers reflects a consistent engagement with teams contributing to immunology and related biomedical research.

Barber's publications have appeared in various venues with multiple contributions in "Regular and Young Investigator Award Abstracts," "PLoS Pathogens," and "bioRxiv (Cold Spring Harbor Laboratory)." Other publication venues include "Nature Cell Biology" and the "Proceedings of the National Academy of Sciences."

Selected recent papers illustrate the focus of Barber's scientific work:

  • STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes, 2023, Nature Cell Biology
  • Epigenetic reprogramming of tumor cell-intrinsic STING function sculpts antigenicity and T cell recognition of melanoma, 2021, Proceedings of the National Academy of Sciences
  • STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases, 2021, European Heart Journal
  • STING regulates metabolic reprogramming in macrophages via HIF-1α during Brucella infection, 2021, PLoS Pathogens
  • Epigenetic state determines the in vivo efficacy of STING agonist therapy, 2023, Nature Communications

Best Publications

  • STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.

    Hiroki Ishikawa;Glen N. Barber

  • STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

    Hiroki Ishikawa;Zhe Ma;Glen N. Barber

  • STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

    Seng Ryong Woo;Mercedes Beatriz Fuertes;Leticia Corrales;Stefani Spranger

  • STING: Infection, inflammation and cancer

    Glen N. Barber

  • Cytoplasmic chromatin triggers inflammation in senescence and cancer

    Zhixun Dou;Kanad Ghosh;Maria Grazia Vizioli;Jiajun Zhu

  • Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein

    Deborah R. Taylor;Stephanie T. Shi;Patrick R. Romano;Glen N. Barber

  • Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF-κB Activation through TBK1

    Takayuki Abe;Glen N. Barber

  • Host defense, viruses and apoptosis.

    G N Barber

  • Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase.

    Antonis E. Koromilas;Sophie Roy;Glen N. Barber;Michael G. Katze

  • Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling

    Hiroyasu Konno;Keiko Konno;Glen N. Barber

  • Activation of STING requires palmitoylation at the Golgi

    Kojiro Mukai;Hiroyasu Konno;Tatsuya Akiba;Takefumi Uemura

  • Essential Role for the dsRNA-Dependent Protein Kinase PKR in Innate Immunity to Viral Infection

    Siddharth Balachandran;Paul C Roberts;Laura E Brown;Ha Truong

  • IRF7: activation, regulation, modification and function

    S Ning;J S Pagano;G N Barber

  • STING manifests self DNA-dependent inflammatory disease

    Jeonghyun Ahn;Delia Gutman;Shinobu Saijo;Glen N. Barber

  • Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase

    Eliane F. Meurs;Julien Galabru;Glen N. Barber;Michael G. Katze

  • DENV inhibits type I IFN production in infected cells by cleaving human STING.

    Sebastian Aguirre;Ana M. Maestre;Sarah Pagni;Jenish R. Patel

  • Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

    Tianli Xia;Hiroyasu Konno;Jeonghyun Ahn;Glen N. Barber

  • Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses

    Thiagarajan Venkataraman;Maikel Valdes;Rachel Elsby;Shigeru Kakuta

  • Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes.

    Nathalie Grandvaux;Marc J. Servant;Benjamin tenOever;Ganes C. Sen

  • Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease.

    Alevtina Gall;Piper Treuting;Keith B. Elkon;Yueh Ming Loo

  • STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling (Nature (2008) 455, (674-678))

    Hiroki Ishikawa;Glen N. Barber

Frequent Co-Authors

Richard G. Vile
Richard G. Vile Mayo Clinic
Timothy Kottke
Timothy Kottke Mayo Clinic
William J. Harrington
William J. Harrington University of Miami
Kah Whye Peng
Kah Whye Peng Mayo Clinic
Gary A. Splitter
Gary A. Splitter University of Wisconsin–Madison
Alan Melcher
Alan Melcher Institute of Cancer Research
Curt M. Horvath
Curt M. Horvath Northwestern University
Sabita Roy
Sabita Roy University of Miami

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