World's Best Scientists 2026 revealed!
John Hiscott

John Hiscott

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Microbiology
Italy
2026
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Molecular Biology
Italy
2026

D-Index & Metrics

Microbiology

D-Index
95
Citations
34553
World Ranking
533
National Ranking
9

Molecular Biology

D-Index
94
Citations
33693
World Ranking
654
National Ranking
10

Medicine

D-Index
96
Citations
34697
World Ranking
9641
National Ranking
333

Research.com Recognitions

  • 2026 - Research.com Microbiology in Italy Leader Award
  • 2026 - Research.com Molecular Biology in Italy Leader Award
  • 2025 - Research.com Microbiology in Italy Leader Award
  • 2025 - Research.com Molecular Biology in Italy Leader Award

Overview

John Hiscott is affiliated with the Istituto Pasteur in Italy and has contributed extensively to the fields of medicine, biochemistry, genetics, molecular biology, immunology, and microbiology. Their research spans various subfields, including immunology, infectious diseases, molecular biology, public health, environmental and occupational health, and oncology.

The main topics explored in their work include interferon and immune responses, mosquito-borne diseases and control, SARS-CoV-2 and COVID-19 research, genomics, phytochemicals, oxidative stress, viral infections and vectors, virus-based gene therapy, and COVID-19 clinical research studies.

John Hiscott has published papers in several notable journals and venues, with a frequent appearance in:

  • Cytokine & Growth Factor Reviews
  • Nature Communications
  • Frontiers in Cellular and Infection Microbiology
  • Research Square
  • Current Opinion in Virology

Notable recent publications include:

  • "The global impact of the coronavirus pandemic," 2020, Cytokine & Growth Factor Reviews
  • "SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate," 2020, Nature Communications
  • "Dengue Virus Targets Nrf2 for NS2B3-Mediated Degradation Leading to Enhanced Oxidative Stress and Viral Replication," 2020, Journal of Virology
  • "Influenza Virus Down-Modulates G6PD Expression and Activity to Induce Oxidative Stress and Promote Its Replication," 2022, Frontiers in Cellular and Infection Microbiology
  • "Type I Interferons in COVID-19 Pathogenesis," 2021, Biology

Throughout their career, John Hiscott has collaborated frequently with several co-authors, including David Olagnier, Enrico Palermo, Michela Muscolini, Tommy Alain, and Christian K. Holm.

Best Publications

  • Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

    Sonia Sharma;Benjamin R. tenOever;Nathalie Grandvaux;Guo-Ping Zhou

  • Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation

    Rongtuan Lin;Christophe Heylbroeck;Paula M. Pitha;John Hiscott

  • VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents

    David F Stojdl;Brian D Lichty;Benjamin R tenOever;Jennifer M Paterson

  • Hostile takeovers: viral appropriation of the NF-kB pathway

    John Hiscott;Hakju Kwon;Pierre Génin

  • Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop.

    J Hiscott;J Marois;J Garoufalis;M D'Addario

  • A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.

    Gregory Gautier;Martine Humbert;Florence Deauvieau;Mathieu Scuiller

  • Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B

    Aseem Kumar;Jaharul Haque;Judith Lacoste;John Hiscott

  • Interferon regulatory factors: the next generation.

    Yael Mamane;Christophe Heylbroeck;Christophe Heylbroeck;Pierre Génin;Pierre Génin;Michele Algarté;Michele Algarté

  • Triggering the Innate Antiviral Response through IRF-3 Activation

    John Hiscott

  • The growing family of interferon regulatory factors

    Hannah Nguyen;John Hiscott;Paula M. Pitha

  • Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes.

    Nathalie Grandvaux;Marc J. Servant;Benjamin tenOever;Ganes C. Sen

  • SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

    David Olagnier;Ensieh Farahani;Jacob Thyrsted;Julia Blay-Cadanet

  • Structural and Functional Analysis of Interferon Regulatory Factor 3: Localization of the Transactivation and Autoinhibitory Domains

    Rongtuan Lin;Yael Mamane;John Hiscott

  • The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.

    Tiejun Zhao;Long Yang;Qiang Sun;Meztli Arguello

  • Essential Role of Interferon Regulatory Factor 3 in Direct Activation of RANTES Chemokine Transcription

    Rongtuan Lin;Christophe Heylbroeck;Pierre Genin;Paula M. Pitha

  • TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB.

    Harald Ehrhardt;Simone Fulda;Irene Schmid;John Hiscott

  • Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways.

    Alessandra Zevini;David Olagnier;John Hiscott

  • Regulation of Type I Interferon Gene Expression by Interferon Regulatory Factor-3

    Susan L. Schafer;Rongtuan Lin;Paul A. Moore;John Hiscott

  • Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3.

    Y.-T. Juang;W. Lowther;M. Kellum;W.-C. Au

  • Convergence of the NF-κB and IRF pathways in the regulation of the innate antiviral response

    John Hiscott

  • The global impact of the coronavirus pandemic.

    John Hiscott;Magdalini Alexandridi;Michela Muscolini;Evelyne Tassone

  • Triggering the interferon response: the role of IRF-3 transcription factor.

    John Hiscott;Paula Pitha;Pierre Genin;Hannah Nguyen

Frequent Co-Authors

Rongtuan Lin
Rongtuan Lin McGill University
Mark A. Wainberg
Mark A. Wainberg McGill University
Qiang Sun
Qiang Sun Peking University
Eliane F. Meurs
Eliane F. Meurs Institut Pasteur
Benjamin R. tenOever
Benjamin R. tenOever Icahn School of Medicine at Mount Sinai
John C. Bell
John C. Bell University of Ottawa
Paula M. Pitha
Paula M. Pitha Johns Hopkins University
Elias K. Haddad
Elias K. Haddad Drexel University
Ilkka Julkunen
Ilkka Julkunen University of Turku
Louis Flamand
Louis Flamand Université Laval

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