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Rongtuan Lin

Rongtuan Lin

D-Index & Metrics

Microbiology

D-Index
77
Citations
20648
World Ranking
1353
National Ranking
42

Overview

Rongtuan Lin is a researcher affiliated with McGill University in Canada. Their work primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on Infectious Diseases and Molecular Biology among other subfields such as Immunology, Pulmonary and Respiratory Medicine, and Genetics.

Their research topics cover a variety of areas including SARS-CoV-2 and COVID-19 research, interferon and immune responses, viral gastroenteritis research and epidemiology, prostate cancer treatment and research, virus-based gene therapy research, RNA regulation and disease, and extracellular vesicles in disease.

Lin has published multiple papers with notable examples including:

  • "A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase" (2021, Antiviral Research)
  • "SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation" (2022, Proceedings of the National Academy of Sciences)
  • "STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer" (2021, Nature Communications)
  • "microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP" (2021, Molecular Cell)
  • "Diterpenoids from Sauropus spatulifolius Leaves with Antimicrobial Activities" (2022, Journal of Natural Products)

Frequent publication venues for Lin's work include Research Square, Nature Communications, Antiviral Research, bioRxiv, and Proceedings of the National Academy of Sciences.

They have collaborated often with co-authors such as Zhenlong Liu, Shan Cen, Tommy Alain, Jian-Yuan Zhao, and Attila Ozsvár.

Best Publications

  • Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

    Sonia Sharma;Benjamin R. tenOever;Nathalie Grandvaux;Guo-Ping Zhou

  • Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation

    Rongtuan Lin;Christophe Heylbroeck;Paula M. Pitha;John Hiscott

  • Interferon regulatory factors: the next generation.

    Yael Mamane;Christophe Heylbroeck;Christophe Heylbroeck;Pierre Génin;Pierre Génin;Michele Algarté;Michele Algarté

  • Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes.

    Nathalie Grandvaux;Marc J. Servant;Benjamin tenOever;Ganes C. Sen

  • Regulation of IRF-3-dependent Innate Immunity by the Papain-like Protease Domain of the Severe Acute Respiratory Syndrome Coronavirus *

    Santhana G. Devaraj;Nan Wang;Zhongbin Chen;Zihong Chen

  • Structural and Functional Analysis of Interferon Regulatory Factor 3: Localization of the Transactivation and Autoinhibitory Domains

    Rongtuan Lin;Yael Mamane;John Hiscott

  • The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.

    Tiejun Zhao;Long Yang;Qiang Sun;Meztli Arguello

  • Essential Role of Interferon Regulatory Factor 3 in Direct Activation of RANTES Chemokine Transcription

    Rongtuan Lin;Christophe Heylbroeck;Pierre Genin;Paula M. Pitha

  • The Herpes Simplex Virus ICP0 RING Finger Domain Inhibits IRF3- and IRF7-Mediated Activation of Interferon-Stimulated Genes

    Rongtuan Lin;Ryan S. Noyce;Susan E. Collins;Roger D. Everett

  • Regulation of Type I Interferon Gene Expression by Interferon Regulatory Factor-3

    Susan L. Schafer;Rongtuan Lin;Paul A. Moore;John Hiscott

  • Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3.

    Y.-T. Juang;W. Lowther;M. Kellum;W.-C. Au

  • Triggering the interferon response: the role of IRF-3 transcription factor.

    John Hiscott;Paula Pitha;Pierre Genin;Hannah Nguyen

  • Multiple regulatory domains control IRF-7 activity in response to virus infection.

    Rongtuan Lin;Yael Mamane;John Hiscott

  • Regulation of RANTES Chemokine Gene Expression Requires Cooperativity Between NF-κB and IFN-Regulatory Factor Transcription Factors

    Pierre Génin;Michèle Algarté;Philippe Roof;Rongtuan Lin

  • Selective DNA Binding and Association with the CREB Binding Protein Coactivator Contribute to Differential Activation of Alpha/Beta Interferon Genes by Interferon Regulatory Factors 3 and 7

    Rongtuan Lin;Pierre Génin;Yaël Mamane;John Hiscott

  • Nlrp6 regulates intestinal antiviral innate immunity.

    Penghua Wang;Shu Zhu;Long Yang;Long Yang;Shuang Cui

  • Identification of the Minimal Phosphoacceptor Site Required for in Vivo Activation of Interferon Regulatory Factor 3 in Response to Virus and Double-stranded RNA

    Marc J. Servant;Nathalie Grandvaux;Benjamin R. tenOever;Delphine Duguay

  • Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage.

    Rongtuan Lin;Judith Lacoste;Peyman Nakhaei;Qiang Sun

  • Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability.

    Rongtuan Lin;P. Beauparlant;C. Makris;S. Meloche

  • Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

    Anne-Louise Smidt Hansen;Gregory J. Buchan;Michael Rühl;Kojiro Mukai

  • HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators.

    Rongtuan Lin;Pierre Genin;Yael Mamane;Marco Sgarbanti;Marco Sgarbanti

  • Negative Regulation of the Retinoic Acid-inducible Gene I-induced Antiviral State by the Ubiquitin-editing Protein A20 *

    Rongtuan Lin;Long Yang;Peyman Nakhaei;Qiang Sun

Frequent Co-Authors

John Hiscott
John Hiscott Istituto Pasteur
Qiang Sun
Qiang Sun Peking University
Eliane F. Meurs
Eliane F. Meurs Institut Pasteur
Erol Fikrig
Erol Fikrig Yale University
Mark A. Wainberg
Mark A. Wainberg McGill University
Benjamin R. tenOever
Benjamin R. tenOever Icahn School of Medicine at Mount Sinai
Ilkka Julkunen
Ilkka Julkunen University of Turku
Elias K. Haddad
Elias K. Haddad Drexel University
Yves Jacob
Yves Jacob Institut Pasteur
Pierre-Olivier Vidalain
Pierre-Olivier Vidalain Claude Bernard University Lyon 1

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