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Biology and Biochemistry

D-Index
75
Citations
31653
World Ranking
5207
National Ranking
2475

Overview

Makarand V. Risbud is affiliated with Thomas Jefferson University in the United States. Their research primarily focuses on various aspects of medicine, with a particular emphasis on spine and intervertebral disc pathology. Their work spans several subfields including pathology and forensic medicine, pharmacology, rheumatology, molecular biology, and genetics.

The scientist's research covers key topics such as:

  • Spine and Intervertebral Disc Pathology
  • Musculoskeletal pain and rehabilitation
  • Osteoarthritis Treatment and Mechanisms
  • Veterinary Orthopedics and Neurology
  • Pain Mechanisms and Treatments
  • Bone Metabolism and Diseases
  • Cancer, Hypoxia, and Metabolism

Their contributions include several frequently published venues, with substantial outputs in bioRxiv (Cold Spring Harbor Laboratory), JOR Spine, Matrix Biology, Orthopaedic Proceedings, and Nature Communications.

Recent notable publications by Makarand V. Risbud include:

  • "Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice," 2021, Nature Communications
  • "Hypoxic Regulation of Mitochondrial Metabolism and Mitophagy in Nucleus Pulposus Cells Is Dependent on HIF-1α-BNIP3 Axis," 2020, Journal of Bone and Mineral Research
  • "Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes," 2020, Matrix Biology
  • "The role of HIF proteins in maintaining the metabolic health of the intervertebral disc," 2021, Nature Reviews Rheumatology
  • "Development of a standardized histopathology scoring system using machine learning algorithms for intervertebral disc degeneration in the mouse model-An ORS spine section initiative," 2021, JOR Spine

Regular collaboration forms an important part of their research. Frequent co-authors include Irving M. Shapiro, Vedavathi Madhu, Emanuel J. Novais, John A. Collins, and Kimheak Sao.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Chitosan: a versatile biopolymer for orthopaedic tissue-engineering.

    Alberto Di Martino;Michael Sittinger;Makarand V. Risbud

  • Role of cytokines in intervertebral disc degeneration: pain and disc content.

    Makarand V. Risbud;Irving M. Shapiro

  • Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems

    Dietmar W Hutmacher;Michael Sittinger;Makarand V Risbud

  • pH-sensitive freeze-dried chitosan–polyvinyl pyrrolidone hydrogels as controlled release system for antibiotic delivery

    Makarand V Risbud;Anandwardhan A Hardikar;Sujata V Bhat;Ramesh R Bhonde

  • The molecular basis of intervertebral disc degeneration.

    Christopher K. Kepler;Ravi K. Ponnappan;Chadi A. Tannoury;Marakand V. Risbud

  • Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy.

    Makarand V Risbud;Todd J Albert;Asha Guttapalli;Edward J Vresilovic

  • Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc

    Daisuke Sakai;Yoshihiko Nakamura;Tomoko Nakai;Taishi Mishima

  • Tissue engineering: advances in in vitro cartilage generation.

    Makarand V Risbud;Michael Sittinger

  • Evidence for skeletal progenitor cells in the degenerate human intervertebral disc.

    Makarand V. Risbud;Asha Guttapalli;Tsung-Ting Tsai;Joon Y. Lee

  • Molecular mechanisms of biological aging in intervertebral discs

    Nam V. Vo;Robert A. Hartman;Prashanti R. Patil;Makarand V. Risbud

  • Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration.

    Zariel I. Johnson;Zachary R. Schoepflin;Hyowon Choi;Irving M. Shapiro

  • TNF-α and IL-1β Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc

    Jianru Wang;Jianru Wang;Dessislava Markova;D. Greg Anderson;Zhaomin Zheng

  • Nucleus pulposus cells express HIF-1α under normoxic culture conditions: A metabolic adaptation to the intervertebral disc microenvironment

    Makarand V. Risbud;Asha Guttapalli;David G. Stokes;David Hawkins

  • Defining the phenotype of young healthy nucleus pulposus cells: recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting.

    Makarand V. Risbud;Zachary R. Schoepflin;Fackson Mwale;Rita A. Kandel

  • Polyacrylamide-chitosan hydrogels: in vitro biocompatibility and sustained antibiotic release studies.

    Makarand V. Risbud;Ramesh R. Bhonde

  • Current strategies for cell delivery in cartilage and bone regeneration.

    Michael Sittinger;Dietmar W Hutmacher;Makarand V Risbud

  • Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

    Emanuel J. Novais;Victoria A. Tran;Shira N. Johnston;Kayla R. Darris

  • Normoxic stabilization of HIF-1α drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk

    Amit Agrawal;Asha Guttapalli;Srinivas Narayan;Todd J. Albert

  • Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2.

    Ramesh Rajpurohit;Makarand V. Risbud;Paul Ducheyne;Edward J. Vresilovic

Frequent Co-Authors

Irving M. Shapiro
Irving M. Shapiro Thomas Jefferson University
Todd J. Albert
Todd J. Albert Hospital for Special Surgery
Alexander R. Vaccaro
Alexander R. Vaccaro Thomas Jefferson University
Ramesh R. Bhonde
Ramesh R. Bhonde Manipal Academy of Higher Education
Daisuke Sakai
Daisuke Sakai Tokai University
James C. Iatridis
James C. Iatridis Icahn School of Medicine at Mount Sinai
Kazuhiro Chiba
Kazuhiro Chiba National Defense Medical College
Ernestina Schipani
Ernestina Schipani University of Michigan–Ann Arbor
Michael Sittinger
Michael Sittinger Charité - University Medicine Berlin
Jonathan R. Brody
Jonathan R. Brody Thomas Jefferson University

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