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D-Index & Metrics

Biology and Biochemistry

D-Index
100
Citations
49688
World Ranking
1489
National Ranking
846

Overview

Irving M. Shapiro is affiliated with Thomas Jefferson University in the United States. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with particular emphasis on subfields such as Pathology and Forensic Medicine, Molecular Biology, Rheumatology, Pharmacology, and Genetics.

Their work extensively covers topics related to Spine and Intervertebral Disc Pathology, Veterinary Orthopedics and Neurology, Musculoskeletal pain and rehabilitation, Osteoarthritis Treatment and Mechanisms, Pregnancy-related medical research, Cancer, Hypoxia, and Metabolism, and Mitochondrial Function and Pathology.

Irving M. Shapiro has contributed to multiple papers including:

  • Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice, 2021, Nature Communications
  • Hypoxic Regulation of Mitochondrial Metabolism and Mitophagy in Nucleus Pulposus Cells Is Dependent on HIF-1α-BNIP3 Axis, 2020, Journal of Bone and Mineral Research
  • Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes, 2020, Matrix Biology
  • The role of HIF proteins in maintaining the metabolic health of the intervertebral disc, 2021, Nature Reviews Rheumatology
  • Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc aging, 2020, Aging Cell

Their frequent co-authors include:

  • Makarand V. Risbud
  • Vedavathi Madhu
  • Emanuel J. Novais
  • Shira N. Johnston
  • Elizabeth S. Silagi

The scientist has published recurrently in venues such as:

  • Journal of Bone and Mineral Research
  • JCI Insight
  • Bone
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • Role of cytokines in intervertebral disc degeneration: pain and disc content.

    Makarand V. Risbud;Irving M. Shapiro

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy.

    Makarand V Risbud;Todd J Albert;Asha Guttapalli;Edward J Vresilovic

  • Decellularized vein as a potential scaffold for vascular tissue engineering

    Patrick J Schaner;Niels D Martin;Thomas N Tulenko;Irving M Shapiro

  • Evidence for skeletal progenitor cells in the degenerate human intervertebral disc.

    Makarand V. Risbud;Asha Guttapalli;Tsung-Ting Tsai;Joon Y. Lee

  • Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration.

    Zariel I. Johnson;Zachary R. Schoepflin;Hyowon Choi;Irving M. Shapiro

  • Immobilized antibiotics to prevent orthopaedic implant infections.

    Noreen J. Hickok;Irving M. Shapiro

  • NUCLEATION AND GROWTH OF CALCIUM PHOSPHATE ON AMINE, CARBOXYL- AND HYDROXYL-SILANE SELF-ASSEMBLED MONOLAYERS

    G.K. Toworfe;R.J. Composto;I.M. Shapiro;I.M. Shapiro;P. Ducheyne

  • Inorganic phosphate induces apoptosis of osteoblast-like cells in culture

    Z. Meleti;I. M. Shapiro;Christopher S. Adams

  • Mechanism of action of beta-glycerophosphate on bone cell mineralization

    Chun-Hsi Chung;Ellis E. Golub;Elizabeth Forbes;Toshikazu Tokuoka

  • Formation of surface reaction products on bioactive glass and their effects on the expression of the osteoblastic phenotype and the deposition of mineralized extracellular matrix.

    A. El-Ghannam;P. Ducheyne;I.M. Shapiro

  • TNF-α and IL-1β Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc

    Jianru Wang;Jianru Wang;Dessislava Markova;D. Greg Anderson;Zhaomin Zheng

  • Nucleus pulposus cells express HIF-1α under normoxic culture conditions: A metabolic adaptation to the intervertebral disc microenvironment

    Makarand V. Risbud;Asha Guttapalli;David G. Stokes;David Hawkins

  • Adaptation of chondrocytes to low oxygen tension: Relationship between hypoxia and cellular metabolism

    Ramesh Rajpurohit;Cameron J. Koch;Zhuliang Tao;Cristina Maria Teixeira

  • Regulated production of mineralization-competent matrix vesicles in hypertrophic chondrocytes.

    Thorsten Kirsch;Hyun Duck Nah;Irving M. Shapiro;Maurizio Pacifici

  • Effect of Serum Proteins on Osteoblast Adhesion to Surface-Modified Bioactive Glass and Hydroxyapatite

    A. El-Ghannam;P. Ducheyne;I. M. Shapiro

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

Frequent Co-Authors

Makarand V. Risbud
Makarand V. Risbud Thomas Jefferson University
Paul Ducheyne
Paul Ducheyne University of Pennsylvania
Todd J. Albert
Todd J. Albert Hospital for Special Surgery
Javad Parvizi
Javad Parvizi Acıbadem Mehmet Ali Aydınlar University
Russell J. Composto
Russell J. Composto University of Pennsylvania
Maurizio Pacifici
Maurizio Pacifici Children's Hospital of Philadelphia
Alexander R. Vaccaro
Alexander R. Vaccaro Thomas Jefferson University
Cameron J. Koch
Cameron J. Koch University of Pennsylvania
Evelina Gatti
Evelina Gatti Aix-Marseille University
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center

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