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D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
15174
World Ranking
5748
National Ranking
2720

Overview

Maurizio Pacifici is affiliated with the Children's Hospital of Philadelphia in the United States. Their research encompasses multiple areas within medicine and biochemistry, genetics, and molecular biology. A significant portion of their work focuses on rheumatology, molecular biology, genetics, pulmonary and respiratory medicine, and oncology.

The main topics covered in Pacifici's research include heterotopic ossification and related conditions, osteoarthritis treatment and mechanisms, TGF-β signaling in diseases, medical imaging and pathology studies, cell adhesion molecules research, genetic syndromes and imprinting, and parathyroid disorders and treatments.

Pacifici has contributed frequently to the following publication venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Signaling
  • Journal of Bone and Mineral Research
  • JBMR Plus
  • Journal of Orthopaedic Research®

Their collaboration network includes regular co-authorships with:

  • Christina Mundy
  • Danielle Rux
  • Lutian Yao
  • Ling Qin
  • Eiki Koyama

Recent papers authored or co-authored by Pacifici demonstrate their ongoing engagement with topics in skeletal and cartilage biology, bone lesion treatments, and disease mechanisms. Notable publications include:

  • "SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation", 2021, Proceedings of the National Academy of Sciences
  • "Activin A promotes the development of acquired heterotopic ossification and is an effective target for disease attenuation in mice", 2021, Science Signaling
  • "Fibrodysplasia Ossificans Progressiva: What Have We Achieved and Where Are We Now? Follow-up to the 2015 Lorentz Workshop", 2021, Frontiers in Endocrinology
  • "Retinoic Acid Receptor Activation Reduces Metastatic Prostate Cancer Bone Lesions by Blocking the Endothelial-to-Osteoblast Transition", 2022, Cancer Research
  • "Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy", 2023, eLife

Best Publications

  • Developmental Regulation of Wnt/β-Catenin Signals Is Required for Growth Plate Assembly, Cartilage Integrity, and Endochondral Ossification

    Yoshihiro Tamamura;Tomohiro Otani;Naoko Kanatani;Eiki Koyama

  • Ascorbic acid induces alkaline phosphatase, type X collagen, and calcium deposition in cultured chick chondrocytes.

    P S Leboy;L Vaias;B Uschmann;E Golub

  • Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists

    Kengo Shimono;Wei En Tung;Wei En Tung;Christine MacOlino;Amber Hsu Tsai Chi

  • A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis.

    Eiki Koyama;Yoshihiro Shibukawa;Motohiko Nagayama;Hiroki Sugito

  • Effect of a tumour promoter on myogenesis

    Robert Cohen;Maurizio Pacifici;Neil Rubinstein;Judy Biehl

  • Mechanisms of synovial joint and articular cartilage formation: recent advances, but many lingering mysteries

    Maurizio Pacifici;Eiki Koyama;Masahiro Iwamoto

  • Regulated production of mineralization-competent matrix vesicles in hypertrophic chondrocytes.

    Thorsten Kirsch;Hyun Duck Nah;Irving M. Shapiro;Maurizio Pacifici

  • Effects of FGF-2/-9 in calvarial bone cell cultures: differentiation stage-dependent mitogenic effect, inverse regulation of BMP-2 and noggin, and enhancement of osteogenic potential.

    Ali Fakhry;Chootima Ratisoontorn;Charulatha Vedhachalam;Imad Salhab

  • Transformation of chondroblasts by Rous sarcoma virus and synthesis of the sulfated proteoglycan matrix.

    Maurizio Pacifici;David Boettiger;Kate Roby;Howard Holtzer

  • Authentic Matrix Vesicles Contain Active Metalloproteases (MMP) A ROLE FOR MATRIX VESICLE-ASSOCIATED MMP-13 IN ACTIVATION OF TRANSFORMING GROWTH FACTOR-β

    Marina D'Angelo;Paul C. Billings;Maurizio Pacifici;Phoebe S. Leboy

  • The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis.

    Motomi Enomoto-Iwamoto;Jirouta Kitagaki;Eiki Koyama;Yoshihiro Tamamura

  • Matrix GLA protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limb.

    Kimitoshi Yagami;Jo-Young Suh;Motomi Enomoto-Iwamoto;Eiki Koyama

  • Cellular and molecular mechanisms of synovial joint and articular cartilage formation.

    Maurizio Pacifici;Eiki Koyama;Yoshihiro Shibukawa;Changshan Wu

  • Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation.

    Salin A Chakkalakal;Kenta Uchibe;Michael R Convente;Deyu Zhang

  • Retinoic acid induces rapid mineralization and expression of mineralization-related genes in chondrocytes.

    Masahiro Iwamoto;Irving M. Shapiro;Kimitoshi Yagami;Adele L. Boskey

  • Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis.

    Eiki Koyama;Blanche Young;Motohiko Nagayama;Yoshihiro Shibukawa

  • MMP-13 is induced during chondrocyte hypertrophy

    Marina D'Angelo;Z. Yan;M. Nooreyazdan;Maurizio Pacifici

  • Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells.

    Rika Yasuhara;Yoichi Ohta;Takahito Yuasa;Takahito Yuasa;Naoki Kondo

  • Temporomandibular joint formation and condyle growth require Indian hedgehog signaling.

    Yoshihiro Shibukawa;Yoshihiro Shibukawa;Blanche Young;Changshan Wu;Satoru Yamada

  • Involvement of α5β1 integrin in matrix interactions and proliferation of chondrocytes

    Motomi Enomoto-Iwamoto;Masahiro Iwamoto;Kazuhisa Nakashima;Yoshiki Mukudai

Frequent Co-Authors

Masahiro Iwamoto
Masahiro Iwamoto University of Maryland, Baltimore
Motomi Enomoto-Iwamoto
Motomi Enomoto-Iwamoto University of Maryland, Baltimore
Howard Holtzer
Howard Holtzer University of Pennsylvania
David Boettiger
David Boettiger University of Pennsylvania
Irving M. Shapiro
Irving M. Shapiro Thomas Jefferson University
Giulio Cossu
Giulio Cossu University of Manchester
Joel Rosenbloom
Joel Rosenbloom Thomas Jefferson University
Sumihare Noji
Sumihare Noji University of Tokushima
Yu Yamaguchi
Yu Yamaguchi Discovery Institute
Paolo Fortina
Paolo Fortina Thomas Jefferson University

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