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Biology and Biochemistry

D-Index
54
Citations
15102
World Ranking
15410
National Ranking
6433

Overview

David Boettiger is a researcher affiliated with the University of Pennsylvania in the United States. Their work spans several interconnected fields within the biomedical sciences, particularly focusing on medicine and biochemistry, genetics, and molecular biology. The main areas of study that emerge from their publications include epidemiology, molecular biology, immunology and allergy, cancer research, and modeling and simulation.

Boettiger's research contributions are reflected in diverse scientific topics. Key themes include:

  • Influenza Virus Research Studies
  • COVID-19 Epidemiological Studies
  • Respiratory Viral Infections Research
  • NF-κB Signaling Pathways
  • Cell Adhesion Molecules Research
  • Melanoma and MAPK Pathways

Their publication record features works in notable scientific journals such as Vaccine and the Journal of Cell Science. Selected recent papers include:

  • The association between influenza vaccination uptake and influenza and pneumonia-associated deaths in the United States, 2024, Vaccine
  • Expression of Concern: α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini, 2023, Journal of Cell Science

Boettiger often collaborates with a range of coauthors, indicating engagement with a wider scientific community. Frequent coauthors include Anthony T. Newall, Allen L. Nazareno, David Muscatello, Cécile Viboud, and Lone Simonsen. This highlights their active participation in multidisciplinary research teams.

Their expertise is applied to understanding complex biological mechanisms such as NF-κB signaling pathways, which are critical in cell survival and immune responses. Additionally, the research addresses public health concerns through epidemiological studies on influenza and respiratory infections, including vaccine uptake and its impact on mortality.

Boettiger's scope of research covers translational topics bridging molecular biology with clinical and population health, reflecting a comprehensive approach to studying infectious diseases and cellular signaling processes.

Best Publications

  • Tensional homeostasis and the malignant phenotype.

    Matthew J. Paszek;Nastaran Zahir;Kandice R. Johnson;Johnathon N. Lakins

  • Mechanically Activated Integrin Switch Controls α5β1 Function

    Julie C. Friedland;Mark H. Lee;David Boettiger

  • Modulation of Cell Proliferation and Differentiation through Substrate-dependent Changes in Fibronectin Conformation

    Andrés J. Garcı́a;Marı́a D. Vega;David Boettiger

  • Occupation of the extracellular matrix receptor, integrin, is a control point for myogenic differentiation

    A S Menko;D Boettiger

  • Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments

    Patrick T. Caswell;May Chan;Andrew J. Lindsay;Mary W. McCaffrey

  • Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate.

    Matthew J. Paszek;David Boettiger;Valerie M. Weaver;Daniel A. Hammer

  • Integrin-fibronectin interactions at the cell-material interface: initial integrin binding and signaling.

    Andrés J Garcı́a;David Boettiger

  • Quantification of cell adhesion using a spinning disc device and application to surface-reactive materials

    Andrés J. García;Paul Ducheyne;David Boettiger

  • Transformation of chondroblasts by Rous sarcoma virus and synthesis of the sulfated proteoglycan matrix.

    Maurizio Pacifici;David Boettiger;Kate Roby;Howard Holtzer

  • Effect of surface reaction stage on fibronectin-mediated adhesion of osteoblast-like cells to bioactive glass

    Andrés J. García;Paul Ducheyne;David Boettiger

  • Effect of biomaterial surface properties on fibronectin–α5β1 integrin interaction and cellular attachment

    Mark H. Lee;Paul Ducheyne;Laura Lynch;David Boettiger

  • Force Required to Break α5β1Integrin-Fibronectin Bonds in Intact Adherent Cells Is Sensitive to Integrin Activation State

    Andrés J. Garcı́a;François Huber;David Boettiger

  • Distinct activation states of α5β1 integrin show differential binding to RGD and synergy domains of fibronectin

    Andrés J. García;Jean E. Schwarzbauer;David Boettiger

  • A Novel Mode for Integrin-mediated Signaling: Tethering Is Required for Phosphorylation of FAK Y397

    Qi Shi;David Boettiger

  • β1 Integrins Mediate Chondrocyte Interaction with Type I Collagen, Type II Collagen, and Fibronectin

    Motomi Enomoto;Phoebe S. Leboy;A.Sue Menko;David Boettiger

  • Involvement of α5β1 integrin in matrix interactions and proliferation of chondrocytes

    Motomi Enomoto-Iwamoto;Masahiro Iwamoto;Kazuhisa Nakashima;Yoshiki Mukudai

  • Regulation of the synthesis of extracellular matrix components in chondroblasts transformed by a temperature-sensitive mutant of Rous sarcoma virus.

    Sherrill L. Adams;David Boettiger;Richard J. Focht;Howard Holtzer

  • Transformation of chicken embryo retinal melanoblasts by a temperature-sensitive mutant of rous sarcoma virus

    Kate Roby;John Brumbaugh;Judy Biehl;Howard Holtzer

  • Two-stage Activation for α5β1Integrin Binding to Surface-adsorbed Fibronectin

    Andrés J. Garcı́a;Junichi Takagi;David Boettiger

  • Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis

    Kyle R Legate;Seiichiro Takahashi;Navid Bonakdar;Ben Fabry

Frequent Co-Authors

Maurizio Pacifici
Maurizio Pacifici Children's Hospital of Philadelphia
Howard Holtzer
Howard Holtzer University of Pennsylvania
Andrés J. García
Andrés J. García Georgia Institute of Technology
Paul Ducheyne
Paul Ducheyne University of Pennsylvania
Daniel A. Hammer
Daniel A. Hammer University of Pennsylvania
Warren S. Pear
Warren S. Pear University of Pennsylvania
Russell J. Composto
Russell J. Composto University of Pennsylvania
Valerie M. Weaver
Valerie M. Weaver University of California, San Francisco
Josephine C. Adams
Josephine C. Adams University of Bristol
Motomi Enomoto-Iwamoto
Motomi Enomoto-Iwamoto University of Maryland, Baltimore

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