Member of the Association of American Physicians
Warren S. Pear mainly focuses on Notch signaling pathway, Cell biology, Signal transduction, Immunology and T cell. He studied Notch signaling pathway and Stem cell that intersect with Adult stem cell. His Cell biology research focuses on Progenitor cell in particular.
In his research, Molecular biology, Notch Family and Hairless is intimately related to Transcription factor, which falls under the overarching field of Signal transduction. His research is interdisciplinary, bridging the disciplines of Cancer research and Immunology. His work deals with themes such as Apoptosis and Leukemia, which intersect with T cell.
His scientific interests lie mostly in Notch signaling pathway, Cell biology, Cancer research, T cell and Immunology. The Notch signaling pathway portion of his research involves studies in Signal transduction and Receptor. His Cell biology research is multidisciplinary, incorporating perspectives in Transcription factor and Cellular differentiation.
His Cancer research study incorporates themes from breakpoint cluster region, Carcinogenesis, Mutation, Leukemia and Bone marrow. His T cell research includes elements of B cell, Cell fate determination and Lymphoma. His Immunology research includes themes of Cell, Lineage, Oncogene and Transgene.
His primary areas of investigation include Cell biology, Notch signaling pathway, Cancer research, Transcription factor and T cell. His study in the field of Progenitor cell, Stem cell and Regeneration is also linked to topics like Population. In his study, HES1 and PCAF is inextricably linked to Leukemia, which falls within the broad field of Notch signaling pathway.
He combines subjects such as Carcinogenesis, Chronic lymphocytic leukemia, B cell and MAPK/ERK pathway with his study of Cancer research. Warren S. Pear interconnects Chromatin, Regulation of gene expression and Cytokine in the investigation of issues within Transcription factor. His T cell study introduces a deeper knowledge of Immunology.
Warren S. Pear spends much of his time researching Cell biology, Transcription factor, Notch signaling pathway, Chromatin and T cell. His work on Regeneration and Signal transduction as part of general Cell biology study is frequently linked to Myofibroblast, therefore connecting diverse disciplines of science. His studies in Transcription factor integrate themes in fields like Regulation of gene expression and Cytokine.
His research integrates issues of Carcinogenesis, Cancer research and Gene rearrangement in his study of Notch signaling pathway. The various areas that Warren S. Pear examines in his Cancer research study include Regulome, B-cell receptor, B cell, Oncogene MYC and Chronic lymphocytic leukemia. The concepts of his Chromatin study are interwoven with issues in Reprogramming, Cell signaling, Epigenetics and RBPJ.
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Production of high titer helper-free retroviruses by transient transfection
Warren S. Pear;Garry P. Nolan;Martin L. Scott;David Baltimore.
Proceedings of the National Academy of Sciences of the United States of America (1994)
Notch1 expression in early lymphopoiesis influences B versus T lineage determination.
John C Pui;David Allman;Lanwei Xu;Susan DeRocco.
Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling.
Barbara Varnum-Finney;Lanwei Xu;Carolyn Brashem-Stein;Cynthia Nourigat.
Nature Medicine (2000)
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
Andrew P. Weng;John M. Millholland;Yumi Yashiro-Ohtani;Marie Laure Arcangeli.
Genes & Development (2006)
Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow
Warren S. Pear;Juli P. Miller;Lanwei Xu;John C. Pui.
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.
Warren S. Pear;Jon C. Aster;Martin L. Scott;Robert P. Hasserjian.
Journal of Experimental Medicine (1996)
REGULATION OF LYMPHOID DEVELOPMENT, DIFFERENTIATION, AND FUNCTION BY THE NOTCH PATHWAY
Ivan Maillard;Terry Fang;Warren S. Pear.
Annual Review of Immunology (2005)
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.
Andrew P. Weng;Yunsun Nam;Michael S. Wolfe;Warren S. Pear.
Molecular and Cellular Biology (2003)
Notch Signaling in Cancer
Eric J. Allenspach;Ivan Maillard;Jon C. Aster;Warren S. Pear.
Cancer Biology & Therapy (2002)
Notch signaling controls the generation and differentiation of early T lineage progenitors.
Arivazhagan Sambandam;Ivan Maillard;Valerie P Zediak;Lanwei Xu.
Nature Immunology (2005)
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