World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
92
Citations
31670
World Ranking
701
National Ranking
382

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Warren S. Pear is affiliated with the University of Pennsylvania in the United States. Their research spans multiple areas within immunology, microbiology, and molecular biology, with a particular focus on immune cell function and interaction as well as T-cell and B-cell immunology.

The scientist's work covers significant topics such as:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Single-cell and spatial transcriptomics
  • IL-33, ST2, and ILC Pathways
  • Genomics and Chromatin Dynamics
  • Epigenetics and DNA Methylation
  • Cell Adhesion Molecules Research

Warren S. Pear has published articles in a range of research journals. Their frequent venues include:

  • Journal of Investigative Dermatology
  • Cell Reports
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • The Journal of Immunology

Their recent papers illustrate diverse research interests and include:

  • TooManyCells identifies and visualizes relationships of single-cell clades (2020, Nature Methods)
  • Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation (2020, PLoS Biology)
  • Whole-Exome and Transcriptome Analysis of UV-Exposed Epidermis and Carcinoma In Situ Reveals Early Drivers of Carcinogenesis (2020, Journal of Investigative Dermatology)
  • Trib1 regulates T cell differentiation during chronic infection by restraining the effector program (2020, The Journal of Experimental Medicine)
  • EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells (2022, Molecular Cell)

Key collaborators frequently working with Warren S. Pear include:

  • Robert B. Faryabi
  • Lanwei Xu
  • Kelly Rome
  • Martha S. Jordan
  • Jelena Petrovic

The scientist's research integrates fields such as immunology and microbiology and biochemistry, genetics, and molecular biology. Within these domains, they focus extensively on immunology, molecular biology, immunology and allergy, oncology, and public health-related areas.

Warren S. Pear is recognized as a member of the Association of American Physicians, reflecting involvement in the medical research community.

Best Publications

  • Production of high titer helper-free retroviruses by transient transfection

    Warren S. Pear;Garry P. Nolan;Martin L. Scott;David Baltimore

  • Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

    John C Pui;David Allman;Lanwei Xu;Susan DeRocco

  • c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

    Andrew P. Weng;John M. Millholland;Yumi Yashiro-Ohtani;Marie Laure Arcangeli

  • Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling.

    Barbara Varnum-Finney;Lanwei Xu;Carolyn Brashem-Stein;Cynthia Nourigat

  • Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

    Warren S. Pear;Juli P. Miller;Lanwei Xu;John C. Pui

  • Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

    Warren S. Pear;Jon C. Aster;Martin L. Scott;Robert P. Hasserjian

  • The Varied Roles of Notch in Cancer

    Jon C. Aster;Warren S. Pear;Stephen C. Blacklow

  • REGULATION OF LYMPHOID DEVELOPMENT, DIFFERENTIATION, AND FUNCTION BY THE NOTCH PATHWAY

    Ivan Maillard;Terry Fang;Warren S. Pear

  • Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.

    Andrew P. Weng;Yunsun Nam;Michael S. Wolfe;Warren S. Pear

  • Regeneration of fat cells from myofibroblasts during wound healing

    Maksim V. Plikus;Maksim V. Plikus;Christian F. Guerrero-Juarez;Mayumi Ito;Yun Rose Li

  • Notch Signaling in Cancer

    Eric J. Allenspach;Ivan Maillard;Jon C. Aster;Warren S. Pear

  • Notch signaling controls the generation and differentiation of early T lineage progenitors.

    Arivazhagan Sambandam;Ivan Maillard;Valerie P Zediak;Lanwei Xu

  • Notch Directly Regulates Gata3 Expression during T Helper 2 Cell Differentiation

    Terry C. Fang;Yumi Yashiro-Ohtani;Cristina Del Bianco;Dawson M. Knoblock

  • Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds.

    Christian F. Guerrero-Juarez;Priya H. Dedhia;Suoqin Jin;Rolando Ruiz-Vega

  • The multifaceted role of Notch in cancer.

    Monideepa Roy;Warren S Pear;Jon C Aster

  • Essential Roles for Ankyrin Repeat and Transactivation Domains in Induction of T-Cell Leukemia by Notch1

    Jon C. Aster;Lanwei Xu;Fredrick G. Karnell;Vytas Patriub

  • Notch signaling is an important regulator of type 2 immunity

    LiLi Tu;Terry C. Fang;David Artis;Olga Shestova

  • Notch signaling in leukemia.

    Jon C. Aster;Warren S. Pear;Stephen C. Blacklow

  • Canonical Notch signaling is dispensable for the maintenance of adult hematopoietic stem cells

    Ivan Maillard;Ute Koch;Alexis Dumortier;Olga Shestova

  • Mastermind critically regulates Notch-mediated lymphoid cell fate decisions

    Ivan Maillard;Andrew P. Weng;Andrea C. Carpenter;Carlos G. Rodriguez

Frequent Co-Authors

Jon C. Aster
Jon C. Aster Harvard Medical School
Ivan Maillard
Ivan Maillard University of Pennsylvania
Stephen C. Blacklow
Stephen C. Blacklow Harvard University
Avinash Bhandoola
Avinash Bhandoola National Institutes of Health
David Allman
David Allman University of Pennsylvania
Bradley E. Bernstein
Bradley E. Bernstein Broad Institute
Martin L. Scott
Martin L. Scott Biogen (United States)
Nancy A. Speck
Nancy A. Speck University of Pennsylvania
Jonathan A. Epstein
Jonathan A. Epstein University of Pennsylvania
George Klein
George Klein Karolinska Institute

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Related Online Degrees & Career Pathways

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