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Biology and Biochemistry

D-Index
95
Citations
40794
World Ranking
1878
National Ranking
1033

Overview

Raphael Kopan is affiliated with Cincinnati Children's Hospital Medical Center in the United States. Their research spans several domains within biochemistry, genetics, molecular biology, and medicine, with a primary focus on molecular biology and pediatrics, perinatology, and child health. Their work encompasses developmental biology, gene regulation, and disease-related genetic studies.

The scientist has contributed extensively to topics such as renal and related cancers, birth, development, and health, as well as epigenetics and DNA methylation. Their research areas also include pregnancy and preeclampsia studies, renal cell carcinoma treatment, and pluripotent stem cells research.

Frequent publication venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of the American Society of Nephrology
  • PLoS Genetics
  • Scientific Reports
  • Nature Communications

Raphael Kopan's collaborative network features several frequent co-authors, among them:

  • Kristina Preuße
  • Praneet Chaturvedi
  • Rhett A. Kovall
  • Matthew R. Hass
  • Meredith P. Schuh

Significant recent research papers include:

  • "Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors", published in 2020 in Developmental Cell
  • "Regulation of nephron progenitor cell lifespan and nephron endowment", published in 2022 in Nature Reviews Nephrology
  • "TSLP disease-associated genetic variants combined with airway TSLP expression influence asthma risk", published in 2021 in Journal of Allergy and Clinical Immunology
  • "Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation", published in 2020 in PLoS Biology
  • "Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism", published in 2020 in eLife

Best Publications

  • The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

    Raphael Kopan;Maria Xenia G Ilagan

  • A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

    Bart De Strooper;Wim Annaert;Philippe Cupers;Paul Saftig

  • Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain.

    Eric H. Schroeter;Jeffrey A. Kisslinger;Raphael Kopan

  • Signalling downstream of activated mammalian Notch.

    Sophie Jarriault;Christel Brou;Frédérique Logeat;Eric H. Schroeter

  • Notch Signaling: From the Outside In

    Jeffrey S. Mumm;Raphael Kopan

  • A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1

    Jeffrey S. Mumm;Eric H. Schroeter;Meera T. Saxena;Adam Griesemer

  • AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

    Jacob S Lee;Marina Cella;Keely G McDonald;Cecilia Garlanda

  • NOTCH AND PRESENILIN: Regulated Intramembrane Proteolysis Links Development and Degeneration

    Dennis Selkoe;Raphael Kopan

  • Gamma-secretase: proteasome of the membrane?

    Raphael Kopan;Ma. Xenia G. Ilagan

  • Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development.

    Frank Costantini;Raphael Kopan

  • Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation.

    Matthew J Hilton;Xiaolin Tu;Ximei Wu;Shuting Bai

  • Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain

    Raphael Kopan;Eric H. Schroeter;Harold Weintraub;Jeffrey S. Nye

  • The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD

    Raphael Kopan;Jeffrey S. Nye;Harold Weintraub

  • Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice

    Youren Tong;Hiroo Yamaguchi;Emilie Giaime;Scott Boyle

  • Human papillomavirus type 16 alters human epithelial cell differentiation in vitro.

    Dennis J. McCance;Raphael Kopan;Elaine Fuchs;Laimonis A. Laimins

  • Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

    Ansuman T. Satpathy;Carlos G. Briseño;Jacob S. Lee;Dennis Ng

  • Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells.

    Luca Pellegrinet;Veronica Rodilla;Zhenyi Liu;Shuang Chen

  • F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation.

    Qi Dong Hu;Qi Dong Hu;Beng Ti Ang;Beng Ti Ang;Meliha Karsak;Wei Ping Hu

  • Intramembrane proteolysis: theme and variations.

    Michael S. Wolfe;Raphael Kopan

  • Patterning a Complex Organ: BranchingMorphogenesisandNephronSegmentation in Kidney Development

    Frank Costantini;Raphael Kopan

Frequent Co-Authors

Taisuke Tomita
Taisuke Tomita University of Tokyo
Alison Goate
Alison Goate Icahn School of Medicine at Mount Sinai
Elaine Fuchs
Elaine Fuchs Rockefeller University
Jie Shen
Jie Shen Eastern Institute of Technology, Ningbo
Michael S. Wolfe
Michael S. Wolfe University of Kansas
Marc Vooijs
Marc Vooijs Maastricht University
Takeshi Iwatsubo
Takeshi Iwatsubo University of Tokyo
Thomas Gridley
Thomas Gridley University of Maine
Yumiko Saga
Yumiko Saga National Institute of Genetics

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