What is he best known for?
The fields of study he is best known for:
His primary scientific interests are in Cell biology, Notch signaling pathway, Cellular differentiation, Notch proteins and Amyloid precursor protein secretase.
His research in Cell biology intersects with topics in Receptor and Cell fate determination.
Notch signaling pathway is a subfield of Signal transduction that Raphael Kopan tackles.
His Signal transduction research is multidisciplinary, relying on both Extracellular, Molecular biology and Membrane protein.
His Cellular differentiation research incorporates elements of Intestinal mucosa, Morphogenesis, Mesenchymal stem cell and Keratin.
His Notch proteins research includes themes of Notch Family and Hes3 signaling axis.
His most cited work include:
- The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism (2361 citations)
- A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. (1850 citations)
- Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. (1449 citations)
What are the main themes of his work throughout his whole career to date?
Raphael Kopan focuses on Cell biology, Notch signaling pathway, Signal transduction, Notch proteins and Cellular differentiation.
His Cell biology course of study focuses on Endocrinology and Mesenchyme.
His Notch signaling pathway research includes elements of Amyloid precursor protein secretase, Transcription factor and Presenilin.
As a part of the same scientific family, Raphael Kopan mostly works in the field of Signal transduction, focusing on Immunology and, on occasion, Haematopoiesis and Cancer research.
His Notch proteins study integrates concerns from other disciplines, such as RBPJ, Cell signaling, Notch Family and Serrate-Jagged Proteins.
He interconnects Embryonic stem cell, Morphogenesis, Mesenchymal stem cell and Keratin in the investigation of issues within Cellular differentiation.
He most often published in these fields:
- Cell biology (69.95%)
- Notch signaling pathway (51.23%)
- Signal transduction (19.70%)
What were the highlights of his more recent work (between 2014-2021)?
- Cell biology (69.95%)
- Notch signaling pathway (51.23%)
- Progenitor cell (12.32%)
In recent papers he was focusing on the following fields of study:
Raphael Kopan mostly deals with Cell biology, Notch signaling pathway, Progenitor cell, Gene and Enhancer.
His study explores the link between Cell biology and topics such as DNA binding site that cross with problems in Chromatin.
All of his Notch signaling pathway and Notch proteins and Hes3 signaling axis investigations are sub-components of the entire Notch signaling pathway study.
His work carried out in the field of Hes3 signaling axis brings together such families of science as Synaptic plasticity, Cell signaling and Cyclin-dependent kinase 8.
Raphael Kopan has researched Progenitor cell in several fields, including PI3K/AKT/mTOR pathway and Nephron.
His work on Gene expression, Cell specific and Genome as part of general Gene research is often related to Mechanism, thus linking different fields of science.
Between 2014 and 2021, his most popular works were:
- The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force (149 citations)
- Notch signal strength controls cell fate in the haemogenic endothelium (88 citations)
- Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan (61 citations)
In his most recent research, the most cited papers focused on:
Cell biology, Notch signaling pathway, Stem cell, Progenitor cell and Kidney development are his primary areas of study.
Specifically, his work in Cell biology is concerned with the study of Signal transduction.
His study of Hes3 signaling axis is a part of Notch signaling pathway.
His work deals with themes such as Endothelial stem cell, Adult stem cell, Ubiquitin, Notch proteins and Cancer stem cell, which intersect with Hes3 signaling axis.
His biological study spans a wide range of topics, including Microarray analysis techniques, JAG1, Cell fate determination and Serrate-Jagged Proteins.
Within one scientific family, Raphael Kopan focuses on topics pertaining to Nephron under Kidney development, and may sometimes address concerns connected to Regulation of gene expression, FGF20, Lesion and TSC1.
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