World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
137
Citations
70381
World Ranking
325
National Ranking
219

Medicine

D-Index
137
Citations
70429
World Ranking
1909
National Ranking
1084

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Jon C. Aster is affiliated with Harvard Medical School in the United States. Their research primarily revolves around the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in Molecular Biology, Immunology, Oncology, Genetics, and Pathology and Forensic Medicine.

The scientist has focused on research topics including Developmental Biology and Gene Regulation, Chronic Lymphocytic Leukemia Research, Lymphoma Diagnosis and Treatment, Epigenetics and DNA Methylation, CAR-T cell therapy research, Immunotherapy and Immune Responses, as well as Immune Cell Function and Interaction.

Jon C. Aster has published extensively in notable scientific journals. Frequent publication venues include:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood Advances
  • Cancer Research
  • Cell

Some of their recent papers include:

  • The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution (2020) - Cell
  • Recruited macrophages elicit atrial fibrillation (2023) - Science
  • Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets (2020) - Clinical Cancer Research
  • FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity (2021) - Nature Communications
  • Pharmacological disruption of the Notch transcription factor complex (2020) - Proceedings of the National Academy of Sciences

Frequent co-authors collaborating with Jon C. Aster include:

  • Stephen C. Blacklow
  • Julia M. Rogers
  • Antonio Ferreira
  • Emily D. Egan
  • Alexandre Martin

Jon C. Aster is a member of the Association of American Physicians.

Best Publications

  • Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

    Andrew P. Weng;Andrew P. Weng;Adolfo A. Ferrando;Adolfo A. Ferrando;Woojoong Lee;Woojoong Lee;John P. Morris;John P. Morris

  • Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

    Margaret A. Shipp;Ken N. Ross;Pablo Tamayo;Andrew P. Weng

  • An immunogenic personal neoantigen vaccine for patients with melanoma

    Patrick A. Ott;Zhuting Hu;Derin B. Keskin;Derin B. Keskin;Sachet A. Shukla;Sachet A. Shukla

  • Comprehensive analyses of tumor immunity: implications for cancer immunotherapy

    Bo Li;Eric Severson;Eric Severson;Jean Christophe Pignon;Haoquan Zhao

  • Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

    John C Pui;David Allman;Lanwei Xu;Susan DeRocco

  • Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

    Annapoorni Rangarajan;Annapoorni Rangarajan;Claudio Talora;Ryuhei Okuyama;Michael Nicolas

  • c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

    Andrew P. Weng;John M. Millholland;Yumi Yashiro-Ohtani;Marie Laure Arcangeli

  • The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma

    Kerry J. Savage;Stefano Monti;Jeffery L. Kutok;Giorgio Cattoretti

  • NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

    Teresa Palomero;Wei Keat Lim;Duncan T. Odom;Maria Luisa Sulis

  • Ibrutinib in Previously Treated Waldenström’s Macroglobulinemia

    Steven P. Treon;Christina K. Tripsas;Kirsten Meid;Diane Warren

  • Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response

    Stefano Monti;Kerry J. Savage;Jeffery L. Kutok;Friedrich Feuerhake

  • Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

    Warren S. Pear;Juli P. Miller;Lanwei Xu;John C. Pui

  • Direct inhibition of the NOTCH transcription factor complex

    Raymond E. Moellering;Raymond E. Moellering;Melanie Cornejo;Tina N. Davis;Cristina Del Bianco

  • Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

    Warren S. Pear;Jon C. Aster;Martin L. Scott;Robert P. Hasserjian

  • Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.

    Peter van Galen;Volker Hovestadt;Marc H. Wadsworth;Marc H. Wadsworth;Marc H. Wadsworth;Travis K. Hughes;Travis K. Hughes;Travis K. Hughes

  • Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells.

    Sanne Weijzen;Paola Rizzo;Mike Braid;Radhika Vaishnav

  • BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma

    E.Elizabeth Patton;Hans R. Widlund;Jeffery L. Kutok;Kamden R. Kopani;Kamden R. Kopani

  • MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.

    Lizi Wu;Jon C. Aster;Stephen C. Blacklow;Robert Lake

  • The Varied Roles of Notch in Cancer

    Jon C. Aster;Warren S. Pear;Stephen C. Blacklow

  • SCF FBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

    Hiroyuki Inuzuka;Shavali Shaik;Ichiro Onoyama;Darning Gao

Frequent Co-Authors

Stephen C. Blacklow
Stephen C. Blacklow Harvard University
Warren S. Pear
Warren S. Pear University of Pennsylvania
Jeffery L. Kutok
Jeffery L. Kutok Epizyme (United States)
Bradley E. Bernstein
Bradley E. Bernstein Broad Institute
Richard Stone
Richard Stone Harvard University
A. Thomas Look
A. Thomas Look Harvard University
Margaret A. Shipp
Margaret A. Shipp Harvard University
James E. Bradner
James E. Bradner Amgen (United States)
Daniel J. DeAngelo
Daniel J. DeAngelo Harvard University
Andrew L. Kung
Andrew L. Kung Memorial Sloan Kettering Cancer Center

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