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Isabella Screpanti

Isabella Screpanti

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Biology and Biochemistry
Italy
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
17076
World Ranking
5699
National Ranking
128

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Italy Leader Award

Overview

Isabella Screpanti is affiliated with Sapienza University of Rome in Italy. Their research contributions span diverse areas within biochemistry, genetics, molecular biology, and medicine, with a specific focus on molecular biology, immunology, cancer research, oncology, and public health. The scientist's work addresses key topics such as NF-κB signaling pathways, T-cell and retrovirus studies, retinoids in leukemia and cellular processes, RNA interference and gene delivery, immune cell function and interaction, acute lymphoblastic leukemia research, and microRNA in disease regulation.

Recent publications by Isabella Screpanti include:

  • Current Trends in ATRA Delivery for Cancer Therapy, 2020, Pharmaceutics
  • CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin, 2021, iScience
  • NOTCH3 signaling is essential for NF-κB activation in TLR-activated macrophages, 2020, Scientific Reports
  • Opsonin-Deficient Nucleoproteic Corona Endows UnPEGylated Liposomes with Stealth Properties In Vivo, 2022, ACS Nano
  • Targeting Notch to Maximize Chemotherapeutic Benefits: Rationale, Advanced Strategies, and Future Perspectives, 2021, Cancers

The scientist frequently publishes in journals including:

  • Scientific Reports
  • Cancers
  • Frontiers in Immunology
  • International Journal of Molecular Sciences
  • Oncogene

Isabella Screpanti collaborates regularly with several co-authors such as María Pía Felli, Giovanna Peruzzi, Saula Checquolo, Claudio Talora, and Maria Pelullo, with repeated joint publications indicating ongoing research partnerships.

Their academic output contains a significant body of work in both biochemistry, genetics, and molecular biology (31 publications) and medicine (19 publications). Within these broader categories, molecular biology stands out as a predominant subfield with 21 publications, followed by immunology with 11, cancer research with 7, and oncology with 6 publications.

Isabella Screpanti's research covers complex mechanisms such as NF-κB signaling, immune cell interactions, and cellular processes related to leukemia and cancer therapy. This includes studies focusing on gene delivery systems and molecular pathways that contribute to disease progression and therapeutic response.

Best Publications

  • Constitutive activation of NF‐κB and T‐cell leukemia/lymphoma in Notch3 transgenic mice

    Diana Bellavia;Antonio F. Campese;Edoardo Alesse;Alessandra Vacca

  • Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice.

    I Screpanti;L Romani;P Musiani;A Modesti

  • Correction: Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma

    Sonia Coni;Anna Barbara Mancuso;Laura Di Magno;Giulia Sdruscia

  • Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells

    Elisabetta Ferretti;Enrico De Smaele;Evelina Miele;Pietro Laneve

  • Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

    Gianluca Canettieri;Lucia Di Marcotullio;Azzura Greco;Sonia Coni

  • Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells

    Emanuela Rosati;Rita Sabatini;Giuliana Rampino;Antonio Tabilio

  • Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.

    Lucia Di Marcotullio;Elisabetta Ferretti;Azzura Greco;Enrico De Smaele

  • MicroRNA profiling in human medulloblastoma

    Elisabetta Ferretti;Enrico De Smaele;Agnese Po;Lucia Di Marcotullio

  • Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements.

    Alessandra Vacca;Maria P. Felli;Antonietta R. Farina;Stefano Martinotti

  • Differential regulation of E2F1 apoptotic target genes in response to DNA damage

    Natalia Pediconi;Alessandra Ianari;Antonio Costanzo;Laura Belloni

  • Heterozygous Germline Mutations in the CBL Tumor-Suppressor Gene Cause a Noonan Syndrome-like Phenotype

    Simone Martinelli;Alessandro De Luca;Emilia Stellacci;Cesare Rossi

  • TrkA alternative splicing: A regulated tumor-promoting switch in human neuroblastoma

    Antonella Tacconelli;Antonietta R. Farina;Lucia Cappabianca;Giuseppina DeSantis

  • Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis

    Diana Bellavia;Antonio F. Campese;Saula Checquolo;Anna Balestri

  • Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development

    Maria Pia Felli;Marella Maroder;Thimios A. Mitsiadis;Antonio F. Campese

  • Hedgehog controls neural stem cells through p53-independent regulation of Nanog

    Agnese Po;Elisabetta Ferretti;Evelina Miele;Enrico De Smaele

  • Steroid sensitivity of thymocyte subpopulations during intrathymic differentiation. Effects of 17 beta-estradiol and dexamethasone on subsets expressing T cell antigen receptor or IL-2 receptor.

    I Screpanti;S Morrone;D Meco;A Santoni

  • RENKCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma

    Lucia Di Marcotullio;Elisabetta Ferretti;Enrico De Smaele;Beatrice Argenti

  • The multiple functions of Numb

    Alberto Gulino;Lucia Di Marcotullio;Isabella Screpanti

  • Human MRE11 is inactivated in mismatch repair‐deficient cancers

    Giuseppe Giannini;Elisabetta Ristori;Fabio Cerignoli;Christian Rinaldi

  • Notch3 and pre-TCR interaction unveils distinct NF-κB pathways in T-cell development and leukemia

    Alessandra Vacca;Maria Pia Felli;Rocco Palermo;Giuseppina Di Mario

Frequent Co-Authors

Alberto Gulino
Alberto Gulino Sapienza University of Rome
Luigi Frati
Luigi Frati Sapienza University of Rome
Elisabetta Ferretti
Elisabetta Ferretti Sapienza University of Rome
Andrea Modesti
Andrea Modesti University of Rome Tor Vergata
Angela Santoni
Angela Santoni Sapienza University of Rome
Stefano Stifani
Stefano Stifani Montreal Neurological Institute and Hospital
Urban Lendahl
Urban Lendahl Karolinska Institute
Felice Giangaspero
Felice Giangaspero Sapienza University of Rome
Irene Bozzoni
Irene Bozzoni Sapienza University of Rome
Giovanni Scambia
Giovanni Scambia Catholic University of the Sacred Heart

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