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Molecular Biology

D-Index
62
Citations
21438
World Ranking
1832
National Ranking
916

Overview

Barbara A. Osborne is affiliated with the University of Massachusetts Amherst in the United States. Their research spans several interconnected fields, primarily in Medicine, Biochemistry, Genetics and Molecular Biology, as well as Immunology and Microbiology.

The scientist's work focuses on various subfields including Immunology, Oncology, Molecular Biology, Hematology, and Physiology. Key research topics cover areas such as Immunotherapy and Immune Responses, CAR-T cell therapy research, T-cell and B-cell Immunology, Immune Cell Function and Interaction, Monoclonal and Polyclonal Antibodies Research, Adenosine and Purinergic Signaling, and Blood transfusion and management.

Barbara A. Osborne has contributed to a number of scientific publications across several respected journals and venues. Frequent publication venues include:

  • Frontiers in Immunology
  • Cancer Research
  • Blood
  • Molecular Therapy
  • Biomacromolecules

Their recent papers highlight the breadth of their research interests, including:

  • "Targeting Notch in oncology: the path forward," 2020, Nature Reviews Drug Discovery
  • "Granzyme B nanoreporter for early monitoring of tumor response to immunotherapy," 2020, Science Advances
  • "Differentiation of Pathogenic Th17 Cells Is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis," 2020, Frontiers in Immunology
  • "Storage temperature determines platelet GPVI levels and function in mice and humans," 2021, Blood Advances
  • "Protein-Antibody Conjugates (PACs): A Plug-and-Play Strategy for Covalent Conjugation and Targeted Intracellular Delivery of Pristine Proteins," 2021, Angewandte Chemie International Edition

Collaboration forms an important part of this scientist's work, as demonstrated by frequent co-authors such as:

  • Lucio Miele
  • Lisa M. Minter
  • Samarpan Majumder
  • Sudarvili Shanthalingam
  • Fokhrul Hossain

Best Publications

  • p53 is required for radiation-induced apoptosis in mouse thymocytes

    Scott W. Lowe;Earlene M. Schmitt;Sallie W. Smith;Barbara A. Osborne

  • Efficacy and Safety of Fluconazole Prophylaxis for Fungal Infections after Marrow Transplantation—A Prospective, Randomized, Double-Blind Study

    M A Slavin;B Osborne;R Adams;M J Levenstein

  • Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells.

    Sanne Weijzen;Paola Rizzo;Mike Braid;Radhika Vaishnav

  • Do all programmed cell deaths occur via apoptosis

    Lawrence M. Schwartz;Sallie W. Smith;Margaret E. E. Jones;Barbara A. Osborne

  • Apoptotic Signals Delivered Through the T-Cell Receptor of a T-Cell Hybrid Require the Immediate-Early Gene Nur77

    Zheng-Gang Liu;Sallie W. Smith;Kelly A. McLaughlin;Lawrence M. Schwartz

  • Programmed cell death, apoptosis and killer genes

    Lawrence M. Schwartz;Barbara A. Osborne

  • Targeting Notch to target cancer stem cells.

    Antonio Pannuti;Kimberly Foreman;Paola Rizzo;Clodia Osipo

  • An Outbreak of Respiratory Syncytial Virus in a Bone Marrow Transplant Center

    Robert D. Harrington;Thomas M. Hooton;Thomas M. Hooton;Robert C. Hackman;Robert C. Hackman;Gregory A. Storch;Gregory A. Storch

  • Rational targeting of Notch signaling in cancer.

    P Rizzo;C Osipo;K Foreman;T Golde

  • Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents

    Brian J Nickoloff;Barbara A Osborne;Lucio Miele

  • Arbiter of differentiation and death: Notch signaling meets apoptosis.

    Lucio Miele;Barbara Osborne

  • Proteasomes play an essential role in thymocyte apoptosis.

    L. M. Grimm;A. L. Goldberg;G. G. Poirier;L. M. Schwartz

  • Cloned transchromosomic calves producing human immunoglobulin

    Yoshimi Kuroiwa;Poothappillai Kasinathan;Yoon J. Choi;Rizwan Naeem

  • Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21

    Lisa M Minter;Danielle M Turley;Pritam Das;Hyun Mu Shin

  • Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28

    J A Punt;B A Osborne;Y Takahama;S O Sharrow

  • Notch1 augments NF-κB activity by facilitating its nuclear retention

    Hyun Mu Shin;Lisa M Minter;Ok Hyun Cho;Sridevi Gottipati

  • Cutting Edge: Protective Effects of Notch-1 on TCR-Induced Apoptosis

    Birgit M. Jehn;Birgit M. Jehn;Wolfgang Bielke;Wolfgang Bielke;Warren S. Pear;Barbara A. Osborne

  • γ-Secretase inhibitors and modulators.

    Todd E. Golde;Edward H. Koo;Kevin M. Felsenstein;Barbara A. Osborne

  • Notch signalling during peripheral T-cell activation and differentiation

    Barbara A. Osborne;Lisa M. Minter

  • Notch-1 Regulates NF-κB Activity in Hemopoietic Progenitor Cells

    Pingyan Cheng;Andrew Zlobin;Veronica Volgina;Sridevi Gottipati

Frequent Co-Authors

Todd E. Golde
Todd E. Golde Emory University
Lucio Miele
Lucio Miele Louisiana State University Health Sciences Center New Orleans
Lucio Miele
Lucio Miele Louisiana State University Health Sciences Center New Orleans
Sankaran Thayumanavan
Sankaran Thayumanavan University of Massachusetts Amherst
Gregory N. Tew
Gregory N. Tew University of Massachusetts Amherst
Juan Anguita
Juan Anguita Ikerbasque
Paulo C. Rodriguez
Paulo C. Rodriguez Moffitt Cancer Center
Leonore A. Herzenberg
Leonore A. Herzenberg Stanford University
David H. Sachs
David H. Sachs Columbia University
Dmitry I. Gabrilovich
Dmitry I. Gabrilovich AstraZeneca (United Kingdom)

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