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Immunology

D-Index
64
Citations
24065
World Ranking
2888
National Ranking
1362

Overview

Paulo C. Rodriguez is affiliated with the Moffitt Cancer Center in the United States. Their research spans a range of topics primarily within medicine, immunology and microbiology, and biochemistry, genetics and molecular biology. The scientist's work focuses heavily on immunology, oncology, molecular biology, cancer research, and epidemiology.

The main topics covered in their research include:

  • Cancer Immunotherapy and Biomarkers
  • Immune Cell Function and Interaction
  • CAR-T cell therapy research
  • Immunotherapy and Immune Responses
  • Immune cells in cancer
  • Phagocytosis and Immune Regulation
  • T-cell and B-cell Immunology

Among their recent notable papers are:

  • Tumor interferon signaling and suppressive myeloid cells are associated with CAR T-cell failure in large B-cell lymphoma, 2021, Blood
  • IgA transcytosis and antigen recognition govern ovarian cancer immunity, 2021, Nature
  • The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake, 2021, Immunity
  • The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling, 2020, Immunity
  • CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint, 2020, Nature Communications

Frequent coauthors collaborating with this scientist include:

  • José R. Conejo-García
  • Xiaoqing Yu
  • Xuefeng Wang
  • Keiran S.M. Smalley
  • Jay K. Mandula

Their work is regularly published in notable venues, with multiple publications in:

  • Cancer Research
  • The Journal of Immunology
  • Immunity
  • Cancer Cell
  • Regular and Young Investigator Award Abstracts

Paulo C. Rodriguez has contributed to over one hundred scientific publications predominantly in medicine, with 91 publications in immunology and microbiology and 50 within biochemistry, genetics, and molecular biology. The scientist's research broadly addresses cancer immunotherapy approaches, immune mechanisms in the tumor microenvironment, and the molecular interactions driving immune regulation and cancer progression.

Best Publications

  • Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

    Vincenzo Bronte;Sven Brandau;Shu Hsia Chen;Mario P. Colombo

  • Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses

    Paulo C. Rodriguez;David G. Quiceno;Jovanny Zabaleta;Blair Ortiz

  • Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine.

    Minu K. Srivastava;Pratima Sinha;Virginia K. Clements;Paulo Rodriguez

  • l-arginine availability regulates T-lymphocyte cell-cycle progression

    Paulo C. Rodriguez;David G. Quiceno;Augusto C. Ochoa

  • Arginase-Producing Myeloid Suppressor Cells in Renal Cell Carcinoma Patients: A Mechanism of Tumor Evasion

    Arnold H. Zea;Paulo C. Rodriguez;Michael B. Atkins;Claudia Hernandez

  • B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

    Ilona Kryczek;Ilona Kryczek;Linhua Zou;Linhua Zou;Paulo Rodriguez;Gefeng Zhu

  • Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes

    Paulo C. Rodriguez;Marc S. Ernstoff;Claudia Hernandez;Michael Atkins

  • Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives.

    Paulo C. Rodríguez;Augusto C. Ochoa

  • Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma.

    Paulo C Rodriguez;Claudia P. Hernandez;David G. Quiceno;Steven M Dubinett

  • Arginase, Prostaglandins, and Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma

    Augusto C. Ochoa;Arnold H. Zea;Claudia Hernandez;Paulo C. Rodriguez

  • l-Arginine Consumption by Macrophages Modulates the Expression of CD3ζ Chain in T Lymphocytes

    Paulo C. Rodriguez;Arnold H. Zea;Joanna DeSalvo;Kirk S. Culotta

  • Regulation of T Cell Receptor CD3ζ Chain Expression byl-Arginine

    Paulo C. Rodriguez;Arnold H. Zea;Kirk S. Culotta;Jovanny Zabaleta

  • Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies

    Fokhrul Hossain;Amir A. Al-Khami;Dorota Wyczechowska;Claudia Hernandez

  • Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13.

    Steven L. Highfill;Paulo C. Rodriguez;Qing Zhou;Christine A. Goetz

  • IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

    Minkyung Song;Tito A. Sandoval;Chang-Suk Chae;Sahil Chopra

  • Metabolism of L-arginine by myeloid-derived suppressor cells in cancer: mechanisms of T cell suppression and therapeutic perspectives.

    Patrick Raber;Augusto C Ochoa;Paulo C Rodríguez

  • Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8+ T Cell Function via l-Arginine Metabolism

    Lyse A. Norian;Paulo C. Rodriguez;Leigh A. O'Mara;Jovanny Zabaleta

  • Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells

    Amir A. Al-Khami;Liqin Zheng;Luis Del Valle;Fokhrul Hossain

  • Subpopulations of myeloid-derived suppressor cells impair T cell responses through independent nitric oxide-related pathways

    Patrick L. Raber;Paul Thevenot;Rosa Sierra;Dorota Wyczechowska

  • Arginine Metabolism in Myeloid Cells Shapes Innate and Adaptive Immunity.

    Paulo C. Rodriguez;Augusto C. Ochoa;Amir A. Al-Khami

  • l-Arginine modulates CD3ζ expression and T cell function in activated human T lymphocytes

    Arnold H. Zea;Paulo C. Rodriguez;Kirk S. Culotta;Claudia P. Hernandez

  • The Stress-Response Sensor Chop Regulates the Function and Accumulation of Myeloid-Derived Suppressor Cells in Tumors

    Paul T. Thevenot;Rosa A. Sierra;Patrick L. Raber;Amir A. Al-Khami

Frequent Co-Authors

Jose R. Conejo-Garcia
Jose R. Conejo-Garcia Duke University
David H. Munn
David H. Munn Augusta University
Luis Del Valle
Luis Del Valle Louisiana State University Health Sciences Center New Orleans
Barbara A. Osborne
Barbara A. Osborne University of Massachusetts Amherst
Ali S. Arbab
Ali S. Arbab Augusta University
Lucio Miele
Lucio Miele Louisiana State University Health Sciences Center New Orleans
Bruce R. Blazar
Bruce R. Blazar University of Minnesota
Weiping Zou
Weiping Zou University of Michigan–Ann Arbor
Krzysztof Reiss
Krzysztof Reiss Louisiana State University Health Sciences Center New Orleans
Walter J. Lukiw
Walter J. Lukiw Louisiana State University

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