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Immunology

D-Index
105
Citations
48319
World Ranking
580
National Ranking
345

Medicine

D-Index
105
Citations
48384
World Ranking
6704
National Ranking
3539

Overview

David H. Munn is affiliated with Augusta University in the United States. Their research primarily spans the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Within these domains, their work is further specialized in Immunology, Oncology, Molecular Biology, Genetics, and Neurology.

The scientist has contributed extensively to topics related to immune cell function and interaction, cancer immunotherapy and biomarkers, immunotherapy and immune responses, immune cells in cancer, glioma diagnosis and treatment, CAR-T cell therapy research, and adenosine and purinergic signaling.

Frequent publication venues for their research include Neuro-Oncology, the Journal for ImmunoTherapy of Cancer, The Journal of Immunology, Cancer Cell, and Blood.

Their recent papers include the following:

  • The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling, 2020, Immunity
  • CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint, 2020, Nature Communications
  • Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses, 2022, Cancer Cell
  • Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma, 2020, Clinical Cancer Research
  • Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment, 2023, Cancer Cell

Among the frequent co-authors collaborating with David H. Munn are Rafał Pacholczyk, Ramses Sadek, Theodore S. Johnson, Eugene P. Kennedy, and Zuzana Berrong.

Best Publications

  • Prevention of allogeneic fetal rejection by tryptophan catabolism

    David H. Munn;Min Zhou;John T. Attwood;Igor Bondarev

  • IDO expression by dendritic cells: tolerance and tryptophan catabolism.

    Andrew L. Mellor;David H. Munn

  • Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

    Nagendra Singh;Ashish Gurav;Sathish Sivaprakasam;Evan Brady

  • INHIBITION OF T CELL PROLIFERATION BY MACROPHAGE TRYPTOPHAN CATABOLISM

    David H. Munn;Ebrahim Shafizadeh;John T. Attwood;Igor Bondarev

  • GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.

    David H. Munn;Madhav D. Sharma;Babak Baban;Heather P. Harding

  • Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

    David H. Munn;Madhav D. Sharma;Jeffrey R. Lee;Kanchan G. Jhaver

  • Indoleamine 2,3-dioxygenase and tumor-induced tolerance.

    David H. Munn;Andrew L. Mellor

  • Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes

    David H. Munn;Madhav D. Sharma;Deyan Hou;Babak Baban

  • Indoleamine 2,3 dioxygenase and metabolic control of immune responses

    David H. Munn;Andrew L. Mellor

  • IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

    David H. Munn;Andrew L. Mellor

  • Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase

    Madhav D. Sharma;Babak Baban;Phillip Chandler;De Yan Hou

  • Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?

    Andrew L Mellor;David H Munn

  • Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

    Qing Zhou;Meghan E. Munger;Rachelle G. Veenstra;Brenda J. Weigel

  • Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

    Rikke B. Holmgaard;Dmitriy Zamarin;David H. Munn;Jedd D. Wolchok;Jedd D. Wolchok;Jedd D. Wolchok

  • Inhibition of Indoleamine 2,3-Dioxygenase in Dendritic Cells by Stereoisomers of 1-Methyl-Tryptophan Correlates with Antitumor Responses

    De Yan Hou;Alexander J. Muller;Madhav D. Sharma;James DuHadaway

  • Ligation of B7-1/B7-2 by Human CD4+ T Cells Triggers Indoleamine 2,3-Dioxygenase Activity in Dendritic Cells

    David H. Munn;Madhav D. Sharma;Andrew L. Mellor

  • Immune suppressive mechanisms in the tumor microenvironment.

    David H Munn;Vincenzo Bronte

  • The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation

    Wei Chen;Xueqing Liang;Amanda J. Peterson;David H. Munn

  • Cutting Edge: Induced Indoleamine 2,3 Dioxygenase Expression in Dendritic Cell Subsets Suppresses T Cell Clonal Expansion

    Andrew L. Mellor;Babak Baban;Phillip Chandler;Brendan Marshall

  • IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

    Babak Baban;Phillip R. Chandler;Madhav D. Sharma;Jeanene Pihkala

  • Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy.

    Andrew L. Mellor;Jayabalan Sivakumar;Phillip Chandler;Kimberly Smith

Frequent Co-Authors

Andrew L. Mellor
Andrew L. Mellor Newcastle University
Bruce R. Blazar
Bruce R. Blazar University of Minnesota
Angela Panoskaltsis-Mortari
Angela Panoskaltsis-Mortari University of Minnesota
Jonathan S. Serody
Jonathan S. Serody University of North Carolina at Chapel Hill
William J. Murphy
William J. Murphy Texas A&M University
Huidong Shi
Huidong Shi Augusta University
Patricia A. Taylor
Patricia A. Taylor University of Minnesota
Ivan Maillard
Ivan Maillard University of Pennsylvania
George C. Prendergast
George C. Prendergast Lankenau Institute for Medical Research
Geoffrey R. Hill
Geoffrey R. Hill Fred Hutchinson Cancer Research Center

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Related Online Degrees & Career Pathways

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