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Paolo Puccetti

Paolo Puccetti

D-Index & Metrics

Immunology

D-Index
95
Citations
34545
World Ranking
895
National Ranking
28

Medicine

D-Index
95
Citations
34549
World Ranking
10038
National Ranking
356

Overview

Paolo Puccetti is affiliated with the University of Perugia in Italy and focuses their research primarily on neuroscience, medicine, and biochemistry, genetics, and molecular biology. The scientist's work spans several subfields including biological psychiatry, molecular biology, immunology, behavioral neuroscience, and pharmacology.

The main topics covered in their research include:

  • Tryptophan and brain disorders
  • Stress responses and cortisol
  • Gut microbiota and health
  • COVID-19 clinical research studies
  • Neuroinflammation and neurodegeneration mechanisms
  • Immune cells in cancer
  • Advanced glycation end products research

Paolo Puccetti has coauthored multiple papers in collaboration with several researchers, with frequent coauthors including Francesca Fallarino, Marco Gargaro, Luigina Romani, Claudio Costantini, and Marilena Pariano.

Notable recent publications include:

  • Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication (2022) in Immunity
  • Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation (2020) in Proceedings of the National Academy of Sciences
  • Tryptophan Metabolites at the Crossroad of Immune-Cell Interaction via the Aryl Hydrocarbon Receptor: Implications for Tumor Immunotherapy (2021) in International Journal of Molecular Sciences
  • Class IA PI3Ks regulate subcellular and functional dynamics of IDO1 (2020) in EMBO Reports
  • Pharmacologic Induction of Endotoxin Tolerance in Dendritic Cells by L-Kynurenine (2020) in Frontiers in Immunology

Their publications often appear in venues such as Proceedings of the National Academy of Sciences, International Journal of Molecular Sciences, Frontiers in Immunology, Immunity, and Trends in Endocrinology and Metabolism.

Best Publications

  • Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

    Teresa Zelante;Rossana G. Iannitti;Cristina Cunha;Antonella De Luca

  • Modulation of tryptophan catabolism by regulatory T cells.

    Francesca Fallarino;Ursula Grohmann;Kwang Woo Hwang;Ciriana Orabona

  • CTLA-4-Ig regulates tryptophan catabolism in vivo.

    Ursula Grohmann;Ciriana Orabona;Francesca Fallarino;Carmine Vacca

  • The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells

    Francesca Fallarino;Ursula Grohmann;Sylvaine You;Barbara C. McGrath

  • T cell apoptosis by tryptophan catabolism.

    Francesca Fallarino;Ursula Grohmann;Carmine Vacca;Roberta Bianchi

  • Tolerance, DCs and tryptophan: much ado about IDO

    Ursula Grohmann;Francesca Fallarino;Paolo Puccetti

  • Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

    Maria T Pallotta;Ciriana Orabona;Claudia Volpi;Carmine Vacca

  • Aryl hydrocarbon receptor control of a disease tolerance defence pathway

    Alban Bessede;Alban Bessede;Marco Gargaro;Maria T. Pallotta;Davide Matino

  • IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.

    Teresa Zelante;Antonella De Luca;Pierluigi Bonifazi;Claudia Montagnoli

  • Natural Killer Cells: Characteristics and Regulation of Activity

    Ronald B. Herberman;Ronald B. Herberman;Ronald B. Herberman;Julie Y. Djeu;Julie Y. Djeu;Julie Y. Djeu;H. David Kay;H. David Kay;H. David Kay;John R. Ortaldo;John R. Ortaldo;John R. Ortaldo

  • Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

    Luigina Romani;Francesca Fallarino;Antonella De Luca;Claudia Montagnoli

  • IL-23 and Th17 Cells Enhance Th2-Cell–mediated Eosinophilic Airway Inflammation in Mice

    Hidefumi Wakashin;Koichi Hirose;Yuko Maezawa;Shin-ichiro Kagami

  • IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-κB activation

    Paolo Puccetti;Ursula Grohmann

  • Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction

    Gianluca Matteoli;Elisa Mazzini;Iliyan D Iliev;Erika Mileti

  • CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86

    Ciriana Orabona;Ursula Grohmann;Maria Laura Belladonna;Francesca Fallarino

  • Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy.

    Ursula Grohmann;Claudia Volpi;Francesca Fallarino;Silvia Bozza

  • Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans.

    L Romani;A Mencacci;E Cenci;R Spaccapelo

  • IL-12 Acts Directly on DC to Promote Nuclear Localization of NF-κB and Primes DC for IL-12 Production

    Ursula Grohmann;Maria Laura Belladonna;Roberta Bianchi;Ciriana Orabona

  • IL-23 and IL-12 Have Overlapping, but Distinct, Effects on Murine Dendritic Cells

    Maria Laura Belladonna;Jean-Christophe Renauld;Roberta Bianchi;Carmine Vacca

  • A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells.

    Giada Mondanelli;Roberta Bianchi;Maria Teresa Pallotta;Ciriana Orabona

  • Interleukin-4 and interleukin-10 inhibit nitric oxide-dependent macrophage killing of Candida albicans.

    Elio Cenci;Luigina Romani;Antonella Mencacci;Roberta Spaccapelo

Frequent Co-Authors

Ursula Grohmann
Ursula Grohmann University of Perugia
Francesca Fallarino
Francesca Fallarino University of Perugia
Maria C. Fioretti
Maria C. Fioretti University of Perugia
Luigina Romani
Luigina Romani University of Perugia
Roberta Bianchi
Roberta Bianchi University of Perugia
Francesco Bistoni
Francesco Bistoni University of Perugia
Carmine Vacca
Carmine Vacca University of Perugia
Ciriana Orabona
Ciriana Orabona University of Perugia
Antonella Mencacci
Antonella Mencacci University of Perugia
Teresa Zelante
Teresa Zelante University of Perugia

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