World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
15020
World Ranking
16959
National Ranking
6989

Overview

Alexander J. Muller is affiliated with the Lankenau Institute for Medical Research in the United States. Their research spans multiple areas within immunology, microbiology, medicine, and neuroscience, with a particular focus on immune mechanisms and their implications for cancer and brain disorders.

Their work addresses various interconnected topics including:

  • Tryptophan and brain disorders
  • Immunotherapy and Immune Responses
  • Immune Cell Function and Interaction
  • Cancer Immunotherapy and Biomarkers
  • Immune cells in cancer
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Stress Responses and Cortisol

Their publication record shows contributions primarily in the fields of immunology and oncology with notable frequent venues such as:

  • Cancer Research
  • The Journal of Immunology
  • Frontiers in Immunology
  • Journal for ImmunoTherapy of Cancer
  • Cancer Immunology Research

Alexander J. Muller's recent scientific papers include:

  • "Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses," 2020, Frontiers in Immunology
  • "Peptide vaccination directed against IDO1-expressing immune cells elicits CD8+ and CD4+ T-cell-mediated antitumor immunity and enhanced anti-PD1 responses," 2020, Journal for ImmunoTherapy of Cancer
  • "IDO1 Signaling through GCN2 in a Subpopulation of Gr-1+ Cells Shifts the IFNγ/IL6 Balance to Promote Neovascularization," 2021, Cancer Immunology Research
  • "Heartbeat Classification by Random Forest With a Novel Context Feature: A Segment Label," 2022, IEEE Journal of Translational Engineering in Health and Medicine
  • "IDO1 and inflammatory neovascularization: bringing new blood to tumor-promoting inflammation," 2023, Frontiers in Oncology

Frequent collaborators reflect a network of researchers engaged in related areas, including:

  • James B. DuHadaway
  • George C. Prendergast
  • Souvik Dey
  • Erika Sutanto-Ward
  • Laura Mandik-Nayak

The subfields addressed in their work highlight a strong concentration in:

  • Immunology
  • Biological Psychiatry
  • Oncology
  • Molecular Biology
  • Neurology

Alexander J. Muller's body of work illustrates an interdisciplinary approach combining immunology, oncology, and neuroscience. This approach focuses on the role of immune cells and signaling pathways such as IDO1 in the modulation of inflammatory and neovascular processes relevant to tumor biology and brain disorders.

Best Publications

  • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

    Tracy G. Lugo;Ann-Marie Pendergast;Alexander J. Muller;Owen N. Witte

  • Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.

    Alexander J Muller;James B DuHadaway;P Scott Donover;Erika Sutanto-Ward

  • Inhibition of Indoleamine 2,3-Dioxygenase in Dendritic Cells by Stereoisomers of 1-Methyl-Tryptophan Correlates with Antitumor Responses

    De Yan Hou;Alexander J. Muller;Madhav D. Sharma;James DuHadaway

  • Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan

    Richard Metz;James B. DuHadaway;Uma Kamasani;Lisa Laury-Kleintop

  • Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance

    Winfried Hinrichs;Caroline Kisker;Martina Düvel;Alexander Müller

  • BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

    A J Muller;J C Young;A M Pendergast;M Pondel

  • Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape.

    Jessica B. Katz;Alexander J. Muller;Alexander J. Muller;George C. Prendergast;George C. Prendergast

  • Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer

    George C. Prendergast;George C. Prendergast;Courtney Smith;Sunil Thomas;Laura Mandik-Nayak

  • Discovery of IDO1 Inhibitors: From Bench to Bedside

    George C. Prendergast;William P. Malachowski;James B. DuHadaway;Alexander J. Muller

  • BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

    Ann Marie Pendergast;Alexander J. Muller;Marie H. Havlik;Yoshiro Maru

  • Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors

    Alexander J. Muller;Peggy A. Scherle

  • The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists

    Sunil Thomas;Jacques Izard;Emily Walsh;Kristen Batich

  • IDO Is a Nodal Pathogenic Driver of Lung Cancer and Metastasis Development

    Courtney Smith;Mee Young Chang;Katherine H. Parker;Daniel W. Beury

  • Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase

    Alexander J. Muller;Madhav D. Sharma;Phillip R. Chandler;James B. DuHadaway

  • Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer.

    George C. Prendergast;George C. Prendergast;William Paul Malachowski;Arpita Mondal;Peggy Scherle

  • Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond

    Alexander J Muller;Mark G Manfredi;Yousef Zakharia;George C Prendergast

  • Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors.

    Paul Gaspari;Tinku Banerjee;William P. Malachowski;Alexander J. Muller

  • A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase

    T Banerjee;J B DuHadaway;P Gaspari;E Sutanto-Ward

  • Indoleamine 2,3-Dioxygenase in Immune Suppression and Cancer

    Alexander J Muller;George C Prendergast

  • Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.

    Sanjeev Kumar;William P. Malachowski;James B. DuHadaway;Judith M. LaLonde

Frequent Co-Authors

George C. Prendergast
George C. Prendergast Lankenau Institute for Medical Research
Owen N. Witte
Owen N. Witte University of California, Los Angeles
Ann Marie Pendergast
Ann Marie Pendergast Duke University
Andrew L. Mellor
Andrew L. Mellor Newcastle University
David H. Munn
David H. Munn Augusta University
Suzanne Ostrand-Rosenberg
Suzanne Ostrand-Rosenberg University of Maryland, Baltimore County
Charles J. Yeo
Charles J. Yeo Thomas Jefferson University
Jonathan R. Brody
Jonathan R. Brody Thomas Jefferson University
Peggy Scherle
Peggy Scherle Incyte (United States)
Arnold J. Levine
Arnold J. Levine Institute for Advanced Study

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring a career in Biology or Biochemistry opens doors to several advanced fields and online programs. Many students look to expand their qualifications or pivot toward healthcare leadership by considering cahme-accredited online mha programs. These degrees focus on healthcare administration, blending science knowledge with management skills.

Those interested in nursing can pursue a terminal nursing degree online. Choose from top options like a dnp program no clinical, which allows you to advance your expertise without the need for onsite clinical practicums.

If you’re passionate about influencing policy or leading large teams, there are cutting-edge doctoral programs for healthcare administration. These programs focus on executive leadership and strategic decision-making in the healthcare sector.

For those aiming for a specialized clinical role, online pharmacy programs provide flexible pathways to earn a doctorate in pharmacy. This can lead to diverse opportunities in research, clinical practice, and pharmaceutical industries.

Best Scientists Citing Alexander J. Muller

Trending Scientists