World's Best Scientists 2026 revealed!

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Medicine

D-Index
142
Citations
130878
World Ranking
1529
National Ranking
888

Research.com Recognitions

  • 2014 - Fellow of the American Academy of Arts and Sciences
  • 2014 - BBVA Foundation Frontiers of Knowledge Award
  • 2013 - Breakthrough Prize in Life Sciences for cancer genes and targeted therapy.
  • 2010 - Member of the National Academy of Sciences
  • 2008 - Member of the National Academy of Medicine (NAM)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Charles L. Sawyers is affiliated with Memorial Sloan Kettering Cancer Center in the United States and has a significant body of work primarily in medicine and biochemistry, genetics, and molecular biology. Their research spans several subfields including pulmonary and respiratory medicine, molecular biology, cancer research, oncology, and radiology, nuclear medicine, and imaging.

The scientist's main topics of study focus on prostate cancer treatment and research, cancer genomics and diagnostics, cancer immunotherapy and biomarkers, radiopharmaceutical chemistry and applications, cancer-related gene regulation, cancer cells and metastasis, and ubiquitin and proteasome pathways.

Frequent coauthors who have collaborated extensively with Charles L. Sawyers include Wouter R. Karthaus, Anuradha Gopalan, Samir Zaidi, Elisa de Stanchina, and Dana Pe'er.

They have published frequently in several key scientific journals, with notable venues including Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, Cancer Cell, and Nature.

Selected recent papers authored or coauthored by Charles L. Sawyers demonstrate the range and focus of their research contributions:

  • Lineage plasticity in cancer: a shared pathway of therapeutic resistance, 2020, Nature Reviews Clinical Oncology
  • Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling, 2022, Science
  • Regenerative potential of prostate luminal cells revealed by single-cell analysis, 2020, Science
  • Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer, 2020, Cancer Cell
  • Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation, 2020, Cancer Cell

Charles L. Sawyers has been recognized with several awards and honors including the Breakthrough Prize in Life Sciences in 2013 for cancer genes and targeted therapy, election to the National Academy of Sciences in 2010, election to the National Academy of Medicine in 2008, the BBVA Foundation Frontiers of Knowledge Award in 2014, and fellowship in the American Academy of Arts and Sciences in 2014. They are also a member of the Association of American Physicians.

Best Publications

  • The phosphatidylinositol 3-Kinase AKT pathway in human cancer.

    Igor Vivanco;Charles L. Sawyers

  • Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

    Brian J. Druker;Moshe Talpaz;Debra J. Resta;Bin Peng

  • Integrative genomic profiling of human prostate cancer

    Barry S. Taylor;Nikolaus Schultz;Haley Hieronymus;Anuradha Gopalan

  • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

    Mercedes E. Gorre;Mansoor Mohammed;Katharine Ellwood;Nicholas Hsu

  • Integrative clinical genomics of advanced prostate cancer

    Dan Robinson;Eliezer M. Van Allen;Eliezer M. Van Allen;Yi Mi Wu;Nikolaus Schultz

  • Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome

    Brian J. Druker;Charles L. Sawyers;Hagop M Kantarjian;Debra J. Resta

  • Molecular determinants of resistance to antiandrogen therapy

    Charlie D Chen;Derek S Welsbie;Chris Tran;Sung Hee Baek

  • Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia

    Hagop M Kantarjian;Charles Sawyers;Andreas Hochhaus;Francois Guilhot

  • Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer

    Chris Tran;Samedy Ouk;Nicola J. Clegg;Yu Chen

  • Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor

    Neil P. Shah;Chris Tran;Francis Y. Lee;Ping Chen

  • Dasatinib in Imatinib-Resistant Philadelphia Chromosome–Positive Leukemias

    Moshe Talpaz;Neil P. Shah;Hagop M Kantarjian;Nicholas Donato

  • Chronic myeloid leukemia.

    Charles L. Sawyers

  • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

    Neil P. Shah;John M. Nicoll;Bhushan Nagar;Mercedes E. Gorre

  • Granulocyte-Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML

    Catriona H M Jamieson;Laurie E Ailles;Scott J Dylla;Manja Muijtjens

  • AACR project genie: Powering precision medicine through an international consortium

    S. M. Sweeney;E. Cerami;A. Baras;T. J. Pugh

  • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

    Ingo K. Mellinghoff;Maria Y. Wang;Igor Vivanco;Daphne A. Haas-Kogan

  • Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study

    Charles L. Sawyers;Andreas Hochhaus;Eric Feldman;John M. Goldman

  • Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

    Colin C. Pritchard;Joaquin Mateo;Michael F. Walsh;Navonil De Sarkar

  • Emerging Mechanisms of Resistance to Androgen Receptor Inhibitors in Prostate Cancer

    Philip A. Watson;Vivek K. Arora;Charles L. Sawyers;Charles L. Sawyers

  • Biology of Progressive, Castration-Resistant Prostate Cancer: Directed Therapies Targeting the Androgen-Receptor Signaling Axis

    Howard I. Scher;Charles L. Sawyers

Frequent Co-Authors

Howard I. Scher
Howard I. Scher Memorial Sloan Kettering Cancer Center
Neil P. Shah
Neil P. Shah University of California, San Francisco
Yu Chen
Yu Chen New York University
Yu Chen
Yu Chen Memorial Sloan Kettering Cancer Center
Nikolaus Schultz
Nikolaus Schultz Memorial Sloan Kettering Cancer Center
Mark A. Rubin
Mark A. Rubin University of Bern
Himisha Beltran
Himisha Beltran Harvard University
Ingo K. Mellinghoff
Ingo K. Mellinghoff Memorial Sloan Kettering Cancer Center
Andrea Sboner
Andrea Sboner Cornell University
Michael J. Morris
Michael J. Morris Memorial Sloan Kettering Cancer Center

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