His primary areas of study are Cancer research, Imatinib mesylate, Imatinib, Chronic myelogenous leukemia and Leukemia. His Cancer research research incorporates themes from Mutation, Tyrosine kinase, Proto-oncogene tyrosine-protein kinase Src, Receptor tyrosine kinase and K562 cells. He has researched Imatinib mesylate in several fields, including Cytarabine and ABL.
His Imatinib study is concerned with Myeloid leukemia in general. His study on Chronic myelogenous leukemia also encompasses disciplines like
Brian J. Druker spends much of his time researching Cancer research, Myeloid leukemia, Imatinib, Leukemia and Imatinib mesylate. His research integrates issues of Tyrosine kinase, ABL, Chronic myelogenous leukemia, Philadelphia chromosome and Kinase in his study of Cancer research. His Myeloid leukemia study combines topics from a wide range of disciplines, such as Myeloid and Progenitor cell, Stem cell.
His Imatinib research integrates issues from Oncology, Tyrosine-kinase inhibitor and Pharmacology. His Leukemia research focuses on Bone marrow and how it relates to Stromal cell. His Imatinib mesylate study frequently links to related topics such as Signal transduction.
His scientific interests lie mostly in Cancer research, Myeloid leukemia, Leukemia, Internal medicine and Cancer. Brian J. Druker does research in Cancer research, focusing on Imatinib mesylate specifically. His biological study spans a wide range of topics, including Ponatinib and ABL.
Brian J. Druker works in the field of Myeloid leukemia, focusing on Imatinib in particular. His work in Leukemia addresses issues such as Bone marrow, which are connected to fields such as Stromal cell and Tumor microenvironment. While the research belongs to areas of Internal medicine, Brian J. Druker spends his time largely on the problem of Oncology, intersecting his research to questions surrounding Tyrosine-kinase inhibitor, Survival analysis and BET inhibitor.
Brian J. Druker mostly deals with Cancer research, Leukemia, Myeloid leukemia, Myeloid and Internal medicine. His work carried out in the field of Cancer research brings together such families of science as Viability assay, Cell, Cell culture, Kinase and Allosteric regulation. His studies in Leukemia integrate themes in fields like Atypical chronic myeloid leukemia, Ruxolitinib and Tyrosine-kinase inhibitor.
Specifically, his work in Myeloid leukemia is concerned with the study of Imatinib. He studies Imatinib, namely Imatinib mesylate. His Internal medicine study which covers Oncology that intersects with Survival analysis, Clinical trial and Precision medicine.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia
Brian J. Druker;Moshe Talpaz;Debra J. Resta;Bin Peng.
The New England Journal of Medicine (2001)
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors.
George Daniel Demetri;Margaret von Mehren;Charles D. Blanke;Annick Diane Van Den Abbeele.
The New England Journal of Medicine (2002)
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells.
Brian J. Druker;Shu Tamura;Elisabeth Buchdunger;Sayuri Ohno.
Nature Medicine (1996)
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
Stephen G. O'Brien;François Guilhot;Richard A. Larson;Insa Gathmann.
The New England Journal of Medicine (2003)
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
Brian J. Druker;François Guilhot;Stephen G. O'brien;Insa Gathmann.
The New England Journal of Medicine (2006)
Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome
Brian J. Druker;Charles L. Sawyers;Hagop M Kantarjian;Debra J. Resta.
The New England Journal of Medicine (2001)
Kinase Mutations and Imatinib Response in Patients With Metastatic Gastrointestinal Stromal Tumor
Michael C. Heinrich;Christopher L. Corless;George D. Demetri;Charles D. Blanke.
Journal of Clinical Oncology (2003)
Effect of the Tyrosine Kinase Inhibitor STI571 in a Patient with a Metastatic Gastrointestinal Stromal Tumor
Heikki Joensuu;Peter J. Roberts;Maarit Sarlomo-Rikala;Leif C. Andersson.
The New England Journal of Medicine (2001)
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
Hagop M Kantarjian;Charles Sawyers;Andreas Hochhaus;Francois Guilhot.
The New England Journal of Medicine (2002)
Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors.
Elisabeth Buchdunger;Catherine L. Cioffi;Norman Law;David Stover.
Journal of Pharmacology and Experimental Therapeutics (2000)
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