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Gregory D. Sempowski

Gregory D. Sempowski

D-Index & Metrics

Immunology

D-Index
78
Citations
20075
World Ranking
1770
National Ranking
872

Overview

Gregory D. Sempowski is a researcher affiliated with Duke University in the United States. Their primary field of study is Medicine, with significant contributions particularly in Infectious Diseases, Molecular Biology, Immunology, Epidemiology, and Animal Science and Zoology. Their research topics predominantly focus on viral infections and immune responses, including extensive work on SARS-CoV-2 and COVID-19.

The scientist's recent papers demonstrate a focus on immunological responses and viral protection mechanisms. Notable publications include:

  • Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites, 2020, Science
  • SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation, 2020, Immunity
  • A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice, 2020, Immunity
  • In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies, 2021, Cell
  • Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses, 2021, Nature

Their frequent co-authors include:

  • Thomas H. Oguin (34 collaborations)
  • Kevin O. Saunders (29 collaborations)
  • Barton F. Haynes (27 collaborations)
  • Andrew N. Macintyre (23 collaborations)
  • Thomas N. Denny (23 collaborations)

Gregory D. Sempowski's work has been published extensively in several scientific venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory) - 19 publications
  • UNC Libraries - 17 publications
  • Proceedings of the National Academy of Sciences - 4 publications
  • Cell - 3 publications
  • Science Advances - 3 publications

Their research covers a range of main topics, reflecting the scope of their expertise, including:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Animal Virus Infections Studies
  • Influenza Virus Research Studies
  • SARS-CoV-2 detection and testing
  • Viral Infections and Outbreaks Research
  • Respiratory viral infections research

Best Publications

  • Immunosenescence of ageing.

    AL Gruver;LL Hudson;GD Sempowski;GD Sempowski

  • Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

    Norbert Pardi;Michael J. Hogan;Rebecca S. Pelc;Hiromi Muramatsu

  • VEGF inhibits T cell development and may contribute to tumor-induced immune suppression

    Joyce E. Ohm;Dmitry I. Gabrilovich;Gregory D. Sempowski;Ekaterina Kisseleva

  • The Role of the Thymus in Immune Reconstitution in Aging, Bone Marrow Transplantation, and HIV-1 Infection

    Haynes Bf;Markert Ml;Sempowski Gd;Patel Dd

  • Thymic involution and immune reconstitution

    Heather E Lynch;Gabrielle L Goldberg;Ann Patricia Chidgey;Marcel R M van den Brink

  • Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites

    Hao Guo;Wei-Chun Chou;Yunjia Lai;Kaixin Liang

  • Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis.

    Kristin M. Fries;Timothy Blieden;Richard J. Looney;Gregory D. Sempowski

  • Inactivation of Lrg-47 and Irg-47 Reveals a Family of Interferon γ–Inducible Genes with Essential, Pathogen-Specific Roles in Resistance to Infection

    Carmen M. Collazo;George S. Yap;Gregory D. Sempowski;Kimberly C. Lusby;Kimberly C. Lusby

  • SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation.

    Katlyn Lederer;Diana Castaño;Diana Castaño;Daniela Gómez Atria;Thomas H. Oguin

  • Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease.

    Benny J. Chen;Xiuyu Cui;Gregory D. Sempowski;Congxiao Liu

  • A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice.

    Dorottya Laczkó;Michael J. Hogan;Sushila A. Toulmin;Philip Hicks

  • Leukemia Inhibitory Factor, Oncostatin M, IL-6, and Stem Cell Factor mRNA Expression in Human Thymus Increases with Age and Is Associated with Thymic Atrophy

    Gregory D. Sempowski;Laura P. Hale;John S. Sundy;Janice M. Massey

  • Neonates Support Lymphopenia-Induced Proliferation

    Booki Min;Rebecca McHugh;Gregory D Sempowski;Crystal Mackall

  • Structural diversity of the SARS-CoV-2 Omicron spike

    Unknown

  • Analysis of the human thymic perivascular space during aging.

    Kristina G. Flores;Jie Li;Gregory D. Sempowski;Barton F. Haynes

  • Changes in primary lymphoid organs with aging

    Ivan K. Chinn;Clare C. Blackburn;Nancy R. Manley;Gregory D. Sempowski

  • Cytokines, leptin, and stress-induced thymic atrophy.

    Amanda L. Gruver;Gregory D. Sempowski

  • In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.

    Dapeng Li;Robert J. Edwards;Kartik Manne;David R. Martinez

  • Orbital Fibroblast Heterogeneity May Determine the Clinical Presentation of Thyroid-Associated Ophthalmopathy

    Terry J. Smith;Laura Koumas;AnneMarie Gagnon;Andrea Bell

  • T cell receptor excision circle assessment of thymopoiesis in aging mice.

    Gregory D. Sempowski;Maria E. Gooding;H.X. Liao;Phong T. Le

  • Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis.

    G D Sempowski;M P Beckmann;S Derdak;R P Phipps

  • VEGF inhibits T cell development and may contribute to tumor-induced immune suppression Running title: VEGF induces dramatic thymic atrophy

    Joyce E. Ohm;Dmitry I. Gabrilovich;Gregory D. Sempowski;Ekaterina Kisseleva

Frequent Co-Authors

Barton F. Haynes
Barton F. Haynes Duke University
Laura P. Hale
Laura P. Hale Duke University
Christopher W. Woods
Christopher W. Woods Duke University
Richard P. Phipps
Richard P. Phipps University of Rochester
Kevin O. Saunders
Kevin O. Saunders Duke University
Nelson J. Chao
Nelson J. Chao Duke University
Herman F. Staats
Herman F. Staats Duke University
Dhavalkumar D. Patel
Dhavalkumar D. Patel University of North Carolina at Chapel Hill
S. Munir Alam
S. Munir Alam Duke University
Priyamvada Acharya
Priyamvada Acharya Duke University

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