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Michael P. Vitek

Michael P. Vitek

D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
21779
World Ranking
4326
National Ranking
2106

Overview

Michael P. Vitek is affiliated with Duke University in the United States. Their research spans primarily the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these broad areas, Vitek has focused on subfields such as Molecular Biology, Nutrition and Dietetics, Physiology, Genetics, and Psychiatry and Mental Health.

The scientist's work addresses several key topics including:

  • Alzheimer's disease research and treatments
  • Cancer, Stress, Anesthesia, and Immune Response
  • Inflammatory mediators and NSAID effects
  • Computational Drug Discovery Methods
  • Metabolomics and Mass Spectrometry Studies
  • Medicinal Plants and Neuroprotection
  • Antimicrobial Peptides and Activities

Vitek has coauthored publications with several frequent collaborators, including Reinaldo B. Oriá, Richard L. Guerrant, Gabriella Cunha Vieira Ciurleo, Orleâncio Gomes Ripardo de Azevedo, and Cirle A. Warren.

The research outputs appear in a variety of scientific venues. Notable publication venues where Vitek has contributed include:

  • Alzheimer s & Dementia Translational Research & Clinical Interventions
  • Frontiers in Microbiology
  • Frontiers in Molecular Biosciences
  • European Journal of Pharmacology
  • Frontiers in Oncology

Recent significant papers authored or coauthored by Michael P. Vitek include:

  • "Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank" (2020) published in Alzheimer s & Dementia Translational Research & Clinical Interventions
  • "Apolipoprotein E mimetic peptide COG1410 combats pandrug-resistant Acinetobacter baumannii" (2022) published in Frontiers in Microbiology
  • "Caspase-1 and the inflammasome promote polycystic kidney disease progression" (2022) published in Frontiers in Molecular Biosciences
  • "Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma" (2020) published in European Journal of Pharmacology
  • "PPP2CA Is a Novel Therapeutic Target in Neuroblastoma Cells That Can Be Activated by the SET Inhibitor OP449" (2022) published in Frontiers in Oncology

The diverse range of topics and venues reflect a research profile that crosses multiple disciplines with special attention to neurodegenerative disease mechanisms, cancer biology, inflammatory processes, and antimicrobial therapeutics.

Best Publications

  • Tau is essential to β-amyloid-induced neurotoxicity

    Mark Rapoport;Hana N. Dawson;Lester I. Binder;Michael P. Vitek

  • Advanced glycation end products contribute to amyloidosis in Alzheimer disease

    M. P. Vitek;Keshab Bhattacharya;J. M. Glendening;E. Stopa

  • Nitric oxide and redox mechanisms in the immune response

    David A. Wink;Harry B. Hines;Robert Y. S. Cheng;Christopher H. Switzer

  • Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

    D Goldgaber;H W Harris;T Hla;T Maciag

  • Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

    Robert A. Rissman;Wayne W. Poon;Mathew Blurton-Jones;Salvatore Oddo

  • Solution NMR Studies of the Aβ(1−40) and Aβ(1−42) Peptides Establish that the Met35 Oxidation State Affects the Mechanism of Amyloid Formation

    Liming Hou;Haiyan Shao;Yongbo Zhang;Hua Li

  • Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice.

    Hana N. Dawson;Adriana Ferreira;Michele V. Eyster;Nupur Ghoshal

  • Microvascular injury and blood-brain barrier leakage in Alzheimer's disease.

    B.D. Zipser;C.E. Johanson;L. Gonzalez;T.M. Berzin

  • Transthyretin sequesters amyloid beta protein and prevents amyloid formation

    A L Schwarzman;L Gregori;M P Vitek;S Lyubski

  • Mechanisms of the antioxidant effects of nitric oxide.

    David A. Wink;Katrina M. Miranda;Michael G. Espey;Ryzard M. Pluta

  • Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD

    Carol A Colton;Ryan T Mott;Hayley Sharpe;Qing Xu

  • APOE Genotype and an ApoE-mimetic Peptide Modify the Systemic and Central Nervous System Inflammatory Response *

    John R. Lynch;Wen Tang;Haichen Wang;Michael P. Vitek

  • Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation

    Olivia A Shipton;Julie R Leitz;Jenny Dworzak;Christine E J Acton

  • APOE genotype-specific differences in the innate immune response.

    Michael P. Vitek;Candice M. Brown;Carol A. Colton

  • Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades

    Hideo Matsuzaki;Michio Tamatani;Atsushi Yamaguchi;Kazuhiko Namikawa

  • Akt Activation Protects Hippocampal Neurons from Apoptosis by Inhibiting Transcriptional Activity of p53

    Atsushi Yamaguchi;Michio Tamatani;Hideo Matsuzaki;Kazuhiko Namikawa

  • Recombinant human interleukin 1 alpha: purification and biological characterization.

    U Gubler;A O Chua;A S Stern;C P Hellmann

  • Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer’s disease

    Donna M. Wilcock;Michael P. Vitek;Carol A. Colton

  • Active glycation in neurofibrillary pathology of Alzheimer disease: Nε-(Carboxymethyl) lysine and hexitol-lysine

    Rudy J Castellani;Peggy L.R Harris;Lawrence M Sayre;Junichi Fujii

  • Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways

    Lisa A. Ridnour;Alisha N. Windhausen;Jeffrey S. Isenberg;Nolan Yeung

Frequent Co-Authors

Carol A. Colton
Carol A. Colton Duke University
Daniel T. Laskowitz
Daniel T. Laskowitz Duke University
David A. Wink
David A. Wink National Institutes of Health
Edward G. Stopa
Edward G. Stopa Brown University
J. Brice Weinberg
J. Brice Weinberg Duke University
David S. Warner
David S. Warner Duke University
Keith T. Wilson
Keith T. Wilson Vanderbilt University Medical Center
Rupesh Chaturvedi
Rupesh Chaturvedi Jawaharlal Nehru University
Warren J. Strittmatter
Warren J. Strittmatter Duke University
Jesús Avila
Jesús Avila Centro de Biología Molecular Severo Ochoa

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