2000 - Member of Academia Europaea
1989 - Fellow of John Simon Guggenheim Memorial Foundation
Transcription factor, Cell biology, Molecular biology, IκB kinase and IKBKG are his primary areas of study. His Transcription factor research incorporates themes from Molecular cloning, Subcellular localization and NF-κB. His studies deal with areas such as Biochemistry and Cellular differentiation as well as Cell biology.
His studies in Molecular biology integrate themes in fields like Notch proteins, Protein subunit, Proto-Oncogene Proteins c-rel, Enhancer and Complementary DNA. The IκB kinase study combines topics in areas such as Ectodermal dysplasia and Immunodeficiency. His research integrates issues of Cancer research, Immunology and Incontinentia pigmenti in his study of IKBKG.
Alain Israël mainly focuses on Cell biology, Molecular biology, Transcription factor, Gene and Signal transduction. His Cell biology research integrates issues from NFKB1 and Ubiquitin. In his study, Antigen is strongly linked to T cell, which falls under the umbrella field of Molecular biology.
His Transcription factor study incorporates themes from NF-κB, Protein subunit, Cellular differentiation and Cytoplasm. His study in Signal transduction is interdisciplinary in nature, drawing from both Receptor, Endocytic vesicle, Protein kinase A and Cell fate determination. His IκB kinase study combines topics in areas such as Autophagy, Kinase and Immunology.
His primary areas of study are Cell biology, Signal transduction, Ubiquitin, NFKB1 and Notch signaling pathway. His work deals with themes such as Biochemistry and Cytokinesis, which intersect with Cell biology. His NFKB1 study integrates concerns from other disciplines, such as Molecular biology, Crystal structure and Incontinentia pigmenti.
The study incorporates disciplines such as Electrophoretic mobility shift assay, Binding protein, Herpes simplex virus, Immunoprecipitation and Binding site in addition to Molecular biology. His work carried out in the field of Notch signaling pathway brings together such families of science as Endocytic cycle, Cell signaling and Ubiquitin ligase. His study with IκB kinase involves better knowledge in Transcription factor.
His primary scientific interests are in Cell biology, Optineurin, NFKB1, Kinase and IκB kinase. Cell biology and Biochemistry are commonly linked in his work. His Optineurin research is multidisciplinary, incorporating elements of Binding protein, Cytoplasm, Cell nucleus, Immunoprecipitation and Molecular biology.
His NFKB1 study results in a more complete grasp of Transcription factor. His biological study spans a wide range of topics, including Mutation, Protein subunit, Regulator, Regulation of gene expression and Binding site. His IκB kinase study focuses on CHUK in particular.
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Signalling downstream of activated mammalian notch
Sophie Jarriault;Christel Brou;Frédérique Logeat;Eric H. Schroeter.
Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation
Shoji Yamaoka;Gilles Courtois;Christine Bessia;Simon T Whiteside.
A Novel Proteolytic Cleavage Involved in Notch Signaling: The Role of the Disintegrin-Metalloprotease TACE
Christel Brou;Frédérique Logeat;Neetu Gupta;Christine Bessia.
Molecular Cell (2000)
The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination
Andrew Kovalenko;Andrew Kovalenko;Christine Chable-Bessia;Giuseppina Cantarella;Giuseppina Cantarella;Alain Israël.
The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product
Mark Kieran;Volker Blank;Frédérique Logeat;Joël Vandekerckhove.
The Notch1 receptor is cleaved constitutively by a furin-like convertase
Frédérique Logeat;Christine Bessia;Christel Brou;Odile LeBail.
Proceedings of the National Academy of Sciences of the United States of America (1998)
Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium.
Asmae Smahi;G. Courtois;P. Vabres;S. Yamaoka.
X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling.
Rainer Döffinger;Asma Smahi;Christine Bessia;Frédéric Geissmann.
Nature Genetics (2001)
The IKK Complex, a Central Regulator of NF-κB Activation
Cold Spring Harbor Perspectives in Biology (2010)
The IKK complex: an integrator of all signals that activate NF-κB?
Trends in Cell Biology (2000)
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