What is he best known for?
The fields of study he is best known for:
Transcription factor, Cell biology, Molecular biology, IκB kinase and IKBKG are his primary areas of study.
His Transcription factor research incorporates themes from Molecular cloning, Subcellular localization and NF-κB.
His studies deal with areas such as Biochemistry and Cellular differentiation as well as Cell biology.
His studies in Molecular biology integrate themes in fields like Notch proteins, Protein subunit, Proto-Oncogene Proteins c-rel, Enhancer and Complementary DNA.
The IκB kinase study combines topics in areas such as Ectodermal dysplasia and Immunodeficiency.
His research integrates issues of Cancer research, Immunology and Incontinentia pigmenti in his study of IKBKG.
His most cited work include:
- Signalling downstream of activated mammalian notch (1293 citations)
- Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation (1010 citations)
- A Novel Proteolytic Cleavage Involved in Notch Signaling: The Role of the Disintegrin-Metalloprotease TACE (1001 citations)
What are the main themes of his work throughout his whole career to date?
Alain Israël mainly focuses on Cell biology, Molecular biology, Transcription factor, Gene and Signal transduction.
His Cell biology research integrates issues from NFKB1 and Ubiquitin.
In his study, Antigen is strongly linked to T cell, which falls under the umbrella field of Molecular biology.
His Transcription factor study incorporates themes from NF-κB, Protein subunit, Cellular differentiation and Cytoplasm.
His study in Signal transduction is interdisciplinary in nature, drawing from both Receptor, Endocytic vesicle, Protein kinase A and Cell fate determination.
His IκB kinase study combines topics in areas such as Autophagy, Kinase and Immunology.
He most often published in these fields:
- Cell biology (39.50%)
- Molecular biology (34.45%)
- Transcription factor (21.85%)
What were the highlights of his more recent work (between 2008-2019)?
- Cell biology (39.50%)
- Signal transduction (16.81%)
- Ubiquitin (15.13%)
In recent papers he was focusing on the following fields of study:
His primary areas of study are Cell biology, Signal transduction, Ubiquitin, NFKB1 and Notch signaling pathway.
His work deals with themes such as Biochemistry and Cytokinesis, which intersect with Cell biology.
His NFKB1 study integrates concerns from other disciplines, such as Molecular biology, Crystal structure and Incontinentia pigmenti.
The study incorporates disciplines such as Electrophoretic mobility shift assay, Binding protein, Herpes simplex virus, Immunoprecipitation and Binding site in addition to Molecular biology.
His work carried out in the field of Notch signaling pathway brings together such families of science as Endocytic cycle, Cell signaling and Ubiquitin ligase.
His study with IκB kinase involves better knowledge in Transcription factor.
Between 2008 and 2019, his most popular works were:
- The IKK Complex, a Central Regulator of NF-κB Activation (443 citations)
- The IKK complex contributes to the induction of autophagy (245 citations)
- NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain (160 citations)
In his most recent research, the most cited papers focused on:
His primary scientific interests are in Cell biology, Optineurin, NFKB1, Kinase and IκB kinase.
Cell biology and Biochemistry are commonly linked in his work.
His Optineurin research is multidisciplinary, incorporating elements of Binding protein, Cytoplasm, Cell nucleus, Immunoprecipitation and Molecular biology.
His NFKB1 study results in a more complete grasp of Transcription factor.
His biological study spans a wide range of topics, including Mutation, Protein subunit, Regulator, Regulation of gene expression and Binding site.
His IκB kinase study focuses on CHUK in particular.
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