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Manolis Pasparakis

Manolis Pasparakis

Award Badge
Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
106
Citations
49809
World Ranking
1139
National Ranking
75

Medicine

D-Index
106
Citations
49824
World Ranking
6436
National Ranking
365

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Manolis Pasparakis is affiliated with the University of Cologne in Germany. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. Within these broad disciplines, their work specifically addresses molecular biology, immunology, cancer research, epidemiology, and oncology.

The scientist's research topics focus on interferon and immune responses, cell death mechanisms and regulation, NF-κB signaling pathways, immune response and inflammation, RNA regulation and disease, inflammasome and immune disorders, and RNA research and splicing.

Manolis Pasparakis has published extensively in several prominent scientific venues. Frequent publication venues include:

  • Nature
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Immunity
  • The Journal of Experimental Medicine

Some of their recent papers are:

  • "Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation" (2020) published in Nature
  • "FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells" (2020) published in Immunity
  • "The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells" (2021) published in Nature Neuroscience
  • "Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation" (2020) published in Nature Communications
  • "ADAR1 averts fatal type I interferon induction by ZBP1" (2022) published in Nature

In their scientific collaborations, Manolis Pasparakis has frequently co-authored with:

  • Laurens Wachsmuth
  • Robin Schwarzer
  • Hamid Kashkar
  • Huipeng Jiao
  • Vangelis Kondylis

Manolis Pasparakis has been recognized with the membership of the European Molecular Biology Organization (EMBO).

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • Necroptosis and its role in inflammation

    Manolis Pasparakis;Peter Vandenabeele

  • Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies.

    Dimitris Kontoyiannis;Manolis Pasparakis;Theresa Torres Pizarro;Fabio Cominelli

  • Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

    Yumiko Imai;Keiji Kuba;Keiji Kuba;G. Greg Neely;Rubina Yaghubian-Malhami

  • Epithelial NEMO links innate immunity to chronic intestinal inflammation

    Arianna Nenci;Christoph Becker;Andy Wullaert;Ralph Gareus

  • Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.

    M Pasparakis;L Alexopoulou;V Episkopou;G Kollias

  • Synchronized renal tubular cell death involves ferroptosis

    Andreas Linkermann;Rachid Skouta;Nina Himmerkus;Shrikant R. Mulay

  • Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis.

    Robert J. Moore;David M. Owens;Gordon Stamp;Caroline Arnott

  • Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

    Melanie Fritsch;Saskia D. Günther;Robin Schwarzer;Marie-Christine Albert

  • Mechanisms regulating skin immunity and inflammation

    Manolis Pasparakis;Ingo Haase;Frank O. Nestle

  • SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.

    Fumiyo Ikeda;Yonathan Lissanu Deribe;Sigrid S. Skånland;Benjamin Stieglitz

  • Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma

    Tom Luedde;Tom Luedde;Naiara Beraza;Vasileios Kotsikoris;Geert van Loo

  • FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

    Patrick-Simon Welz;Andy Wullaert;Katerina Vlantis;Vangelis Kondylis

  • Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer.

    Daniel Schramek;Andreas Leibbrandt;Verena Sigl;Lukas Kenner

  • Regulation of tissue homeostasis by NF-κB signalling: implications for inflammatory diseases

    Manolis Pasparakis

  • NF-κB in the regulation of epithelial homeostasis and inflammation.

    Andy Wullaert;Marion C Bonnet;Manolis Pasparakis

  • NEMO/IKKγ-Deficient Mice Model Incontinentia Pigmenti

    Marc Schmidt-Supprian;Wilhelm Bloch;Gilles Courtois;Klaus Addicks

  • TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2

    Manolis Pasparakis;Gilles Courtois;Martin Hafner;Martin Hafner;Marc Schmidt-Supprian;Marc Schmidt-Supprian

  • RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

    Marius Dannappel;Katerina Vlantis;Snehlata Kumari;Apostolos Polykratis

  • RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

    Yasushi Ito;Dimitry Ofengeim;Ayaz Najafov;Sudeshna Das

Frequent Co-Authors

George Kollias
George Kollias National and Kapodistrian University of Athens
Geert van Loo
Geert van Loo Ghent University
Klaus Rajewsky
Klaus Rajewsky Max Delbrück Center for Molecular Medicine
Michelle A. Kelliher
Michelle A. Kelliher University of Massachusetts Chan Medical School
Marc Schmidt-Supprian
Marc Schmidt-Supprian Technical University of Munich
Christian Trautwein
Christian Trautwein RWTH Aachen University
Lena Alexopoulou
Lena Alexopoulou Centre d’Immunologie de Marseille-Luminy
George Kassiotis
George Kassiotis The Francis Crick Institute
John Silke
John Silke Walter and Eliza Hall Institute of Medical Research
Peter Vandenabeele
Peter Vandenabeele Ghent University

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