What is she best known for?
The fields of study she is best known for:
- Immune system
- Cytokine
- Virus
Her primary scientific interests are in TLR3, Immunology, Virology, Toll-like receptor and Tumor necrosis factor alpha.
TLR3 is a subfield of Receptor that Lena Alexopoulou studies.
Her Inflammation, Immune system, Anti-dsDNA antibodies and Antibody study in the realm of Immunology connects with subjects such as Toll-Like Receptor 9.
Her research in Virology tackles topics such as Innate immune system which are related to areas like RNA and Orthomyxoviridae.
Her Tumor necrosis factor alpha study integrates concerns from other disciplines, such as Colitis, Inflammatory bowel disease and Antigen.
Her Cell biology research incorporates themes from TLR7 and Dendritic cell.
Her most cited work include:
- Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. (5144 citations)
- Recognition of single-stranded RNA viruses by Toll-like receptor 7 (1491 citations)
- Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. (1030 citations)
What are the main themes of her work throughout her whole career to date?
The scientist’s investigation covers issues in Immunology, Innate immune system, Receptor, Immune system and TLR3.
In the subject of general Immunology, her work in Inflammation, Tumor necrosis factor alpha, Toll-like receptor and TLR7 is often linked to TLR9, thereby combining diverse domains of study.
Lena Alexopoulou has included themes like RNA, Signal transduction, Cytokine and Microbiology in her Innate immune system study.
Her Receptor research includes themes of Acquired immune system, Molecular biology, Gene targeting and Cell biology.
Her TLR3 research includes elements of Virus, Virology, Downregulation and upregulation and Lung.
Her work on Encephalitis and Flavivirus as part of general Virology study is frequently connected to RNA silencing, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them.
She most often published in these fields:
- Immunology (78.12%)
- Innate immune system (67.71%)
- Receptor (56.25%)
What were the highlights of her more recent work (between 2013-2019)?
- Innate immune system (67.71%)
- TLR7 (31.25%)
- Immune system (50.00%)
In recent papers she was focusing on the following fields of study:
Lena Alexopoulou mainly investigates Innate immune system, TLR7, Immune system, Autoimmunity and Systemic lupus erythematosus.
Her research integrates issues of Immunofluorescence Microscopy, Pathogen and Internalization in her study of Innate immune system.
Her TLR7 study is focused on Immunology in general.
Her Immunology research is multidisciplinary, incorporating elements of Small interfering RNA, Gene knockdown and Virology.
Her Immune system research is multidisciplinary, incorporating perspectives in Receptor and Intracellular, Cell biology.
She combines subjects such as Tumor necrosis factor alpha, Myeloid, Cancer research, Pathogenesis and Germinal center with her study of Systemic lupus erythematosus.
Between 2013 and 2019, her most popular works were:
- TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice (79 citations)
- TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice (79 citations)
- TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice (79 citations)
In her most recent research, the most cited papers focused on:
- Immune system
- Cytokine
- Virus
Lena Alexopoulou focuses on TLR7, Autoimmune disease, Autoantibody, Immunology and Systemic lupus erythematosus.
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