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Immunology

D-Index
55
Citations
28788
World Ranking
3767
National Ranking
174

Overview

Lena Alexopoulou is affiliated with the Centre d'Immunologie de Marseille-Luminy in France. Their research is primarily situated at the intersection of immunology, microbiology, medicine, and molecular biology. The scientist's work spans various subfields including immunology, molecular biology, pulmonary and respiratory medicine, physiology, and genetics.

The research topics addressed in their publications focus on:

  • Immune responses and vaccinations
  • Epigenetics and DNA methylation
  • Neonatal respiratory health research
  • Salivary gland disorders and functions
  • Immune cell function and interaction
  • Immune response and inflammation
  • Diabetes and associated disorders

Recent papers authored or co-authored by Lena Alexopoulou include:

  • "Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo," 2022, Nature Immunology
  • "TLR7 Signaling Drives the Development of Sjögren's Syndrome," 2021, Frontiers in Immunology
  • "Nucleic acid-sensing toll-like receptors: Important players in Sjögren's syndrome," 2022, Frontiers in Immunology
  • "Toll-like receptors (TLRs) in the trained immunity era," 2025, eLife
  • "Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections," 2025, Nature Immunology

The scientist has collaborated frequently with several researchers, including:

  • Michael H. Sieweke
  • Sethuraman Subramanian
  • Clara Jana-Lui Busch
  • Kaaweh Molawi
  • Laufey Geirsdóttir

Lena Alexopoulou's works have been published mainly in these venues:

  • Nature Immunology
  • Frontiers in Immunology
  • eLife
  • Research Square
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.

    Lena Alexopoulou;Agnieszka Czopik Holt;Ruslan Medzhitov;Richard A. Flavell

  • Recognition of single-stranded RNA viruses by Toll-like receptor 7

    Jennifer M. Lund;Lena Alexopoulou;Ayuko Sato;Margaret Karow

  • Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

    Tian Wang;Terrence Town;Lena Alexopoulou;Lena Alexopoulou;John F Anderson

  • Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

    Koichi Tabeta;Philippe Georgel;Edith Janssen;Xin Du

  • Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.

    M Pasparakis;L Alexopoulou;V Episkopou;G Kollias

  • Toll-like receptor 3 promotes cross-priming to virus-infected cells

    Oliver Schulz;Sandra S. Diebold;Margaret Chen;Tanja I. Näslund

  • Viral infection switches non-plasmacytoid dendritic cells into high interferon producers

    Sandra S Diebold;Maria Montoya;Hermann Unger;Lena Alexopoulou

  • Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia.

    Ronan Le Goffic;Ronan Le Goffic;Viviane Balloy;Viviane Balloy;Micheline Lagranderie;Lena Alexopoulou;Lena Alexopoulou

  • Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

    Sean R. Christensen;Michael Kashgarian;Lena Alexopoulou;Richard A. Flavell

  • Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice

    Lena Alexopoulou;Venetta Thomas;Markus Schnare;Yves Lobet

  • Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways

    Kasper Hoebe;Edith M. Janssen;Sung O. Kim;Lena Alexopoulou

  • PREDOMINANT PATHOGENIC ROLE OF TUMOR NECROSIS FACTOR IN EXPERIMENTAL COLITIS IN MICE

    Markus F. Neurath;Ivan Fuss;Manolis Pasparakis;Lena Alexopoulou

  • Does Toll-like receptor 3 play a biological role in virus infections?

    Kurt H Edelmann;Sarah Richardson-Burns;Lena Alexopoulou;Kenneth L Tyler

  • Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3

    Marianna Kulka;Lena Alexopoulou;Richard A Flavell;Dean D Metcalfe

  • Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria

    Vincent Feuillet;Samir Medjane;Isabelle Mondor;Olivier Demaria

  • Cutting Edge: Priming of NK Cells by IL-18

    Julie Chaix;Marlowe S. Tessmer;Kasper Hoebe;Nicolas Fuséri

  • Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells.

    Martin Guilliams;Karine Crozat;Sandrine Henri;Samira Tamoutounour

  • Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1

    Suzana P Salcedo;María Ines Marchesini;Hugues Lelouard;Emilie Fugier

  • Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology

    Dimitris Kontoyiannis;Alexey Kotlyarov;Ester Carballo;Lena Alexopoulou

  • Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor.

    Manolis Pasparakis;Lena Alexopoulou;Matthias Grell;Klaus Pfizenmaier

Frequent Co-Authors

Richard A. Flavell
Richard A. Flavell Yale University
George Kollias
George Kollias National and Kapodistrian University of Athens
Manolis Pasparakis
Manolis Pasparakis University of Cologne
Erol Fikrig
Erol Fikrig Yale University
Terrence Town
Terrence Town University of Southern California
Kasper Hoebe
Kasper Hoebe Johnson & Johnson (United States)
Sandrine Henri
Sandrine Henri Centre d’Immunologie de Marseille-Luminy
Shizuo Akira
Shizuo Akira Osaka University
Marc Dalod
Marc Dalod Centre d’Immunologie de Marseille-Luminy
George Kassiotis
George Kassiotis The Francis Crick Institute

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