World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
136
Citations
109971
World Ranking
332
National Ranking
224

Medicine

D-Index
136
Citations
109749
World Ranking
1934
National Ranking
1099

Research.com Recognitions

  • 2013 - Fellow of the American Academy of Arts and Sciences
  • 2012 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Genetics/Molecular Biology and Cell Biology
  • 2011 - Nobel Prize for their discoveries concerning the activation of innate immunity
  • 2009 - Albany Medical Center Prize in Medicine and Biomedical Research
  • 2008 - Member of the National Academy of Medicine (NAM)
  • 2008 - Member of the National Academy of Sciences
  • 2004 - Robert Koch Prize
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Bruce Beutler is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology.

The scientist's work has contributed extensively to subfields including Molecular Biology, Immunology, Genetics, Cell Biology, and Physiology. The main research topics cover Immune Cell Function and Interaction, T-cell and B-cell Immunology, Immune Response and Inflammation, Endoplasmic Reticulum Stress and Disease, Pancreatic function and diabetes, Ubiquitin and proteasome pathways, and CRISPR and Genetic Engineering.

Recent papers authored or co-authored by Bruce Beutler include:

  • Tumour predisposition and cancer syndromes as models to study gene-environment interactions, 2020, Nature reviews. Cancer
  • Emerging roles of spliceosome in cancer and immunity, 2021, Protein & Cell
  • SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity, 2021, Science
  • Sulfatides are endogenous ligands for the TLR4-MD-2 complex, 2021, Proceedings of the National Academy of Sciences
  • KDM5A mutations identified in autism spectrum disorder using forward genetics, 2020, eLife

Frequent co-authors who have collaborated with Bruce Beutler include:

  • Eva Marie Y. Moresco
  • Sara Ludwig
  • Xiaohong Li
  • Miao Tang
  • Jin Huk Choi

Key venues where Bruce Beutler's scholarly work has appeared frequently are:

  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Scientific Reports
  • The Journal of Experimental Medicine

The scientist has received several awards, including the Nobel Prize in 2011 for discoveries concerning the activation of innate immunity. Other recognitions include:

  • Fellow of the American Academy of Arts and Sciences, 2013
  • German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften, 2012, Genetics/Molecular Biology and Cell Biology
  • Albany Medical Center Prize in Medicine and Biomedical Research, 2009
  • Member of the National Academy of Sciences, 2008
  • Member of the National Academy of Medicine (NAM), 2008
  • Robert Koch Prize, 2004
  • Member of the Association of American Physicians

Best Publications

  • Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

    Alexander Poltorak;Xiaolong He;Irina Smirnova;Mu Ya Liu

  • Shock and tissue injury induced by recombinant human cachectin.

    Kevin J. Tracey;Bruce A Beutler;Stephen F. Lowry;James Merryweather

  • Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin

    Bruce Beutler;Ian W. Milsark;Anthony C. Cerami

  • The biology of cachectin/TNF--a primary mediator of the host response

    Bruce A Beutler;A. Cerami

  • Cachectin and tumour necrosis factor as two sides of the same biological coin

    Bruce Beutler;Anthony Cerami

  • Inferences, questions and possibilities in Toll-like receptor signalling

    Bruce Beutler

  • CACHECTIN: MORE THAN A TUMOR NECROSIS FACTOR

    B. Beutler;A. Cerami

  • Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators

    D. Caput;Bruce A Beutler;K. Hartog;R. Thayer

  • Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1

    Charles A. Dinarello;Joseph G. Cannon;Sheldon M. Wolff;Harry A. Bernheim

  • Innate immune sensing and its roots: the story of endotoxin

    Bruce A Beutler;Ernst Th Rietschel

  • TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY

    Argyrios N. Theofilopoulos;Roberto Baccala;Bruce A Beutler;Dwight H. Kono

  • The Tumor Necrosis Factor Ligand and Receptor Families

    Flavia Bazzoni;Bruce A Beutler

  • Identity of tumour necrosis factor and the macrophage-secreted factor cachectin.

    B. Beutler;D. Greenwald;J. D. Hulmes;M. Chang

  • Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance

    Bruce Beutler;Nadia Krochin;Ian W. Milsark;Christina Luedke

  • Innate immunity: an overview.

    Bruce A Beutler

  • Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

    J M Dayer;B Beutler;A Cerami

  • Intracellular Toll-like Receptors

    Amanda L. Blasius;Bruce Beutler

  • Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.

    K. Hoebe;X. Du;P. Georgel;E. Janssen

  • Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

    Leonid Gitlin;Winfried Barchet;Susan Gilfillan;Marina Cella

  • Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections

    Jochen Mattner;Kristin L. DeBord;Nahed Ismail;Randal D. Goff

Frequent Co-Authors

Kasper Hoebe
Kasper Hoebe Johnson & Johnson (United States)
Anthony Cerami
Anthony Cerami Araim Pharmaceuticals (United States)
Karine Crozat
Karine Crozat Aix-Marseille University
Philippe Georgel
Philippe Georgel University of Strasbourg
Argyrios N. Theofilopoulos
Argyrios N. Theofilopoulos Scripps Research Institute
Zhengfan Jiang
Zhengfan Jiang Peking University
Dale L. Boger
Dale L. Boger Scripps Research Institute
Jiahuai Han
Jiahuai Han Xiamen University
Dwight H. Kono
Dwight H. Kono Scripps Research Institute
Christopher C. Goodnow
Christopher C. Goodnow Garvan Institute of Medical Research

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