2013 - Fellow of the American Academy of Arts and Sciences
2012 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Genetics/Molecular Biology and Cell Biology
2011 - Nobel Prize for their discoveries concerning the activation of innate immunity
2009 - Albany Medical Center Prize in Medicine and Biomedical Research
2008 - Member of the National Academy of Medicine (NAM)
2008 - Member of the National Academy of Sciences
2004 - Robert Koch Prize
Member of the Association of American Physicians
Bruce Beutler focuses on Tumor necrosis factor alpha, Immunology, Signal transduction, Receptor and Innate immune system. Bruce Beutler has researched Tumor necrosis factor alpha in several fields, including Inflammation, Wasting, Macrophage and Cytokine. His Signal transduction study integrates concerns from other disciplines, such as Molecular biology and Toll-like receptor.
His Toll-like receptor research integrates issues from Positional cloning and TLR4. His Receptor study combines topics from a wide range of disciplines, such as In vitro, Lipoprotein lipase and Autoimmunity. Bruce Beutler combines subjects such as Antigen, Immunity and Virology with his study of Innate immune system.
His scientific interests lie mostly in Immunology, Tumor necrosis factor alpha, Cell biology, Receptor and Molecular biology. The concepts of his Tumor necrosis factor alpha study are interwoven with issues in Inflammation, Lipoprotein lipase and Cytokine. His biological study spans a wide range of topics, including Interferon, Antigen and T cell.
His research integrates issues of Toll and Signal transduction in his study of Receptor. The Signal transduction study which covers TRIF that intersects with TLR3 and Signal transducing adaptor protein. His Innate immune system research is multidisciplinary, incorporating elements of Positional cloning, Acquired immune system, Gene and Immunity.
His primary areas of investigation include Cell biology, Genetics, Receptor, Forward genetics and Immunology. He studies Signal transduction which is a part of Cell biology. His work on Phenotype, Genome, Gene and Mutation as part of general Genetics study is frequently linked to Atopy, bridging the gap between disciplines.
In general Receptor study, his work on Toll-like receptor and Agonist often relates to the realm of Mechanism, thereby connecting several areas of interest. The Forward genetics study combines topics in areas such as Retinal and Computational biology. In his work, Molecular biology is strongly intertwined with MHC class I, which is a subfield of Endoplasmic reticulum.
His primary areas of study are Cell biology, Signal transduction, Cancer research, Receptor and Genetics. The various areas that Bruce Beutler examines in his Cell biology study include RNA, Cell cycle, Inflammasome and TLR7. His studies in Signal transduction integrate themes in fields like TLR8, Transmembrane protein, Disintegrin, Metalloproteinase and Transmembrane domain.
His work in the fields of Receptor, such as Toll-like receptor, TLR4 and Agonist, intersects with other areas such as Mechanism. In his study, Molecular biology is inextricably linked to Protein kinase B, which falls within the broad field of Missense mutation. His Ubiquitin ligase research is multidisciplinary, relying on both Endocrinology and Internal medicine.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak;Xiaolong He;Irina Smirnova;Mu Ya Liu.
Shock and tissue injury induced by recombinant human cachectin.
Kevin J. Tracey;Bruce A Beutler;Stephen F. Lowry;James Merryweather.
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin
Bruce Beutler;Ian W. Milsark;Anthony C. Cerami.
The biology of cachectin/TNF--a primary mediator of the host response
Bruce A Beutler;A. Cerami.
Annual Review of Immunology (1989)
Cachectin and tumour necrosis factor as two sides of the same biological coin
Bruce Beutler;Anthony Cerami.
Cachectin: more than a tumor necrosis factor.
B. Beutler;A. Cerami.
The New England Journal of Medicine (1987)
Inferences, questions and possibilities in Toll-like receptor signalling
Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators
D. Caput;Bruce A Beutler;K. Hartog;R. Thayer.
Proceedings of the National Academy of Sciences of the United States of America (1986)
Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1
Charles A. Dinarello;Joseph G. Cannon;Sheldon M. Wolff;Harry A. Bernheim.
Journal of Experimental Medicine (1986)
The Tumor Necrosis Factor Ligand and Receptor Families
Flavia Bazzoni;Bruce A Beutler.
The New England Journal of Medicine (1996)
Profile was last updated on December 6th, 2021.
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