D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 98 Citations 56,176 233 World Ranking 276 National Ranking 176
Medicine D-index 108 Citations 73,453 294 World Ranking 2605 National Ranking 1513

Research.com Recognitions

Awards & Achievements

2013 - Fellow of the American Academy of Arts and Sciences

2012 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Genetics/Molecular Biology and Cell Biology

2011 - Nobel Prize for their discoveries concerning the activation of innate immunity

2009 - Albany Medical Center Prize in Medicine and Biomedical Research

2008 - Member of the National Academy of Medicine (NAM)

2008 - Member of the National Academy of Sciences

2004 - Robert Koch Prize

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Immune system

Bruce Beutler focuses on Tumor necrosis factor alpha, Immunology, Signal transduction, Receptor and Innate immune system. Bruce Beutler has researched Tumor necrosis factor alpha in several fields, including Inflammation, Wasting, Macrophage and Cytokine. His Signal transduction study integrates concerns from other disciplines, such as Molecular biology and Toll-like receptor.

His Toll-like receptor research integrates issues from Positional cloning and TLR4. His Receptor study combines topics from a wide range of disciplines, such as In vitro, Lipoprotein lipase and Autoimmunity. Bruce Beutler combines subjects such as Antigen, Immunity and Virology with his study of Innate immune system.

His most cited work include:

  • Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene (6761 citations)
  • Shock and tissue injury induced by recombinant human cachectin. (2296 citations)
  • Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin (2141 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Immunology, Tumor necrosis factor alpha, Cell biology, Receptor and Molecular biology. The concepts of his Tumor necrosis factor alpha study are interwoven with issues in Inflammation, Lipoprotein lipase and Cytokine. His biological study spans a wide range of topics, including Interferon, Antigen and T cell.

His research integrates issues of Toll and Signal transduction in his study of Receptor. The Signal transduction study which covers TRIF that intersects with TLR3 and Signal transducing adaptor protein. His Innate immune system research is multidisciplinary, incorporating elements of Positional cloning, Acquired immune system, Gene and Immunity.

He most often published in these fields:

  • Immunology (29.49%)
  • Tumor necrosis factor alpha (23.84%)
  • Cell biology (22.83%)

What were the highlights of his more recent work (between 2013-2021)?

  • Cell biology (22.83%)
  • Genetics (15.76%)
  • Receptor (21.62%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Cell biology, Genetics, Receptor, Forward genetics and Immunology. He studies Signal transduction which is a part of Cell biology. His work on Phenotype, Genome, Gene and Mutation as part of general Genetics study is frequently linked to Atopy, bridging the gap between disciplines.

In general Receptor study, his work on Toll-like receptor and Agonist often relates to the realm of Mechanism, thereby connecting several areas of interest. The Forward genetics study combines topics in areas such as Retinal and Computational biology. In his work, Molecular biology is strongly intertwined with MHC class I, which is a subfield of Endoplasmic reticulum.

Between 2013 and 2021, his most popular works were:

  • NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component (284 citations)
  • K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria (162 citations)
  • Comparison of predicted and actual consequences of missense mutations (133 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

His primary areas of study are Cell biology, Signal transduction, Cancer research, Receptor and Genetics. The various areas that Bruce Beutler examines in his Cell biology study include RNA, Cell cycle, Inflammasome and TLR7. His studies in Signal transduction integrate themes in fields like TLR8, Transmembrane protein, Disintegrin, Metalloproteinase and Transmembrane domain.

His work in the fields of Receptor, such as Toll-like receptor, TLR4 and Agonist, intersects with other areas such as Mechanism. In his study, Molecular biology is inextricably linked to Protein kinase B, which falls within the broad field of Missense mutation. His Ubiquitin ligase research is multidisciplinary, relying on both Endocrinology and Internal medicine.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Alexander Poltorak;Xiaolong He;Irina Smirnova;Mu Ya Liu.
Science (1998)

9165 Citations

Shock and tissue injury induced by recombinant human cachectin.

Kevin J. Tracey;Bruce A Beutler;Stephen F. Lowry;James Merryweather.
Science (1986)

3274 Citations

Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin

Bruce Beutler;Ian W. Milsark;Anthony C. Cerami.
Science (1985)

3074 Citations

The biology of cachectin/TNF--a primary mediator of the host response

Bruce A Beutler;A. Cerami.
Annual Review of Immunology (1989)

2315 Citations

Cachectin and tumour necrosis factor as two sides of the same biological coin

Bruce Beutler;Anthony Cerami.
Nature (1986)

2117 Citations

Cachectin: more than a tumor necrosis factor.

B. Beutler;A. Cerami.
The New England Journal of Medicine (1987)

2053 Citations

Inferences, questions and possibilities in Toll-like receptor signalling

Bruce Beutler.
Nature (2004)

2016 Citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators

D. Caput;Bruce A Beutler;K. Hartog;R. Thayer.
Proceedings of the National Academy of Sciences of the United States of America (1986)

1956 Citations

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1

Charles A. Dinarello;Joseph G. Cannon;Sheldon M. Wolff;Harry A. Bernheim.
Journal of Experimental Medicine (1986)

1923 Citations

The Tumor Necrosis Factor Ligand and Receptor Families

Flavia Bazzoni;Bruce A Beutler.
The New England Journal of Medicine (1996)

1646 Citations

Best Scientists Citing Bruce Beutler

Shizuo Akira

Shizuo Akira

Osaka University

Publications: 380

Jean-Laurent Casanova

Jean-Laurent Casanova

Rockefeller University

Publications: 163

Douglas T. Golenbock

Douglas T. Golenbock

University of Massachusetts Medical School

Publications: 137

Laurent Abel

Laurent Abel

Inserm : Institut national de la santé et de la recherche médicale

Publications: 124

Kensuke Miyake

Kensuke Miyake

University of Tokyo

Publications: 122

Charles A. Dinarello

Charles A. Dinarello

University of Colorado Denver

Publications: 120

Osamu Takeuchi

Osamu Takeuchi

Kyoto University

Publications: 118

Kevin J. Tracey

Kevin J. Tracey

Feinstein Institute for Medical Research

Publications: 112

Stefanie N. Vogel

Stefanie N. Vogel

University of Maryland, Baltimore

Publications: 107

Richard A. Flavell

Richard A. Flavell

Yale University

Publications: 101

Mihai G. Netea

Mihai G. Netea

Radboud University Nijmegen

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Katherine A. Fitzgerald

Katherine A. Fitzgerald

University of Massachusetts Medical School

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Hermann Wagner

Hermann Wagner

Technical University of Munich

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Kiyoshi Takeda

Kiyoshi Takeda

Osaka University

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Luke A. J. O'Neill

Luke A. J. O'Neill

Trinity College Dublin

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Carsten J. Kirschning

Carsten J. Kirschning

University of Duisburg-Essen

Publications: 82

Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking d-index is inferred from publications deemed to belong to the considered discipline.

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