What is he best known for?
The fields of study he is best known for:
- Gene
- Enzyme
- Immune system
Bruce Beutler focuses on Tumor necrosis factor alpha, Immunology, Signal transduction, Receptor and Innate immune system.
Bruce Beutler has researched Tumor necrosis factor alpha in several fields, including Inflammation, Wasting, Macrophage and Cytokine.
His Signal transduction study integrates concerns from other disciplines, such as Molecular biology and Toll-like receptor.
His Toll-like receptor research integrates issues from Positional cloning and TLR4.
His Receptor study combines topics from a wide range of disciplines, such as In vitro, Lipoprotein lipase and Autoimmunity.
Bruce Beutler combines subjects such as Antigen, Immunity and Virology with his study of Innate immune system.
His most cited work include:
- Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene (6761 citations)
- Shock and tissue injury induced by recombinant human cachectin. (2296 citations)
- Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin (2141 citations)
What are the main themes of his work throughout his whole career to date?
His scientific interests lie mostly in Immunology, Tumor necrosis factor alpha, Cell biology, Receptor and Molecular biology.
The concepts of his Tumor necrosis factor alpha study are interwoven with issues in Inflammation, Lipoprotein lipase and Cytokine.
His biological study spans a wide range of topics, including Interferon, Antigen and T cell.
His research integrates issues of Toll and Signal transduction in his study of Receptor.
The Signal transduction study which covers TRIF that intersects with TLR3 and Signal transducing adaptor protein.
His Innate immune system research is multidisciplinary, incorporating elements of Positional cloning, Acquired immune system, Gene and Immunity.
He most often published in these fields:
- Immunology (29.49%)
- Tumor necrosis factor alpha (23.84%)
- Cell biology (22.83%)
What were the highlights of his more recent work (between 2013-2021)?
- Cell biology (22.83%)
- Genetics (15.76%)
- Receptor (21.62%)
In recent papers he was focusing on the following fields of study:
His primary areas of investigation include Cell biology, Genetics, Receptor, Forward genetics and Immunology.
He studies Signal transduction which is a part of Cell biology.
His work on Phenotype, Genome, Gene and Mutation as part of general Genetics study is frequently linked to Atopy, bridging the gap between disciplines.
In general Receptor study, his work on Toll-like receptor and Agonist often relates to the realm of Mechanism, thereby connecting several areas of interest.
The Forward genetics study combines topics in areas such as Retinal and Computational biology.
In his work, Molecular biology is strongly intertwined with MHC class I, which is a subfield of Endoplasmic reticulum.
Between 2013 and 2021, his most popular works were:
- NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component (284 citations)
- K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria (162 citations)
- Comparison of predicted and actual consequences of missense mutations (133 citations)
In his most recent research, the most cited papers focused on:
His primary areas of study are Cell biology, Signal transduction, Cancer research, Receptor and Genetics.
The various areas that Bruce Beutler examines in his Cell biology study include RNA, Cell cycle, Inflammasome and TLR7.
His studies in Signal transduction integrate themes in fields like TLR8, Transmembrane protein, Disintegrin, Metalloproteinase and Transmembrane domain.
His work in the fields of Receptor, such as Toll-like receptor, TLR4 and Agonist, intersects with other areas such as Mechanism.
In his study, Molecular biology is inextricably linked to Protein kinase B, which falls within the broad field of Missense mutation.
His Ubiquitin ligase research is multidisciplinary, relying on both Endocrinology and Internal medicine.
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