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Osamu Takeuchi

Osamu Takeuchi

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Immunology
Japan
2025
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Medicine
Japan
2023

D-Index & Metrics

Immunology

D-Index
133
Citations
138997
World Ranking
204
National Ranking
11

Medicine

D-Index
133
Citations
139003
World Ranking
2169
National Ranking
41

Research.com Recognitions

  • 2025 - Research.com Immunology in Japan Leader Award
  • 2023 - Research.com Medicine in Japan Leader Award
  • 2023 - Research.com Microbiology in Japan Leader Award
  • 2022 - Research.com Microbiology in Japan Leader Award

Overview

Osamu Takeuchi is affiliated with Kyoto University in Japan. Their research predominantly spans the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology.

The scientist's work covers several specialized subfields, including Molecular Biology, Immunology, Atomic and Molecular Physics and Optics, Electrical and Electronic Engineering, and Cancer Research.

Main topics featured in their research include:

  • RNA Research and Splicing
  • RNA modifications and cancer
  • Immune Cell Function and Interaction
  • Interferon and immune responses
  • Ubiquitin and proteasome pathways
  • T-cell and B-cell Immunology
  • RNA and protein synthesis mechanisms

Some of the recent papers authored by Osamu Takeuchi's team are:

  • Terahertz Scanning Tunneling Microscopy for Visualizing Ultrafast Electron Motion in Nanoscale Potential Variations (2021, ACS Photonics)
  • RNA Recognition and Immunity-Innate Immune Sensing and Its Posttranscriptional Regulation Mechanisms (2020, Cells)
  • The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells (2020, Science Immunology)
  • Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages (2022, Circulation)
  • Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by regnase-1 (2020, European Respiratory Journal)

The researcher frequently publishes in the following venues:

  • Nature Communications
  • Applied Physics Express
  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Photonics
  • International Immunology

Osamu Takeuchi has collaborated extensively with other researchers. Frequent co-authors include:

  • Hidemi Shigekawa
  • Takuya Uehata
  • Masanori Yoshinaga
  • Takashi Mino
  • Yusuke Arashida

Best Publications

  • Pathogen Recognition and Innate Immunity

    Shizuo Akira;Satoshi Uematsu;Osamu Takeuchi

  • Pattern Recognition Receptors and Inflammation

    Osamu Takeuchi;Shizuo Akira

  • A Toll-like receptor recognizes bacterial DNA.

    Hiroaki Hemmi;Osamu Takeuchi;Taro Kawai;Tsuneyasu Kaisho

  • Erratum A Toll-like receptor recognizes bacterial DNA

    Hiroaki Hemmi;Osamu Takeuchi;Taro Kawai;Tsuneyasu Kaisho

  • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product.

    Katsuaki Hoshino;Osamu Takeuchi;Taro Kawai;Hideki Sanjo

  • Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

    Hiroki Kato;Osamu Takeuchi;Shintaro Sato;Mitsutoshi Yoneyama

  • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

    Osamu Takeuchi;Katsuaki Hoshino;Taro Kawai;Hideki Sanjo

  • Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.

    Masahiro Yamamoto;Shintaro Sato;Hiroaki Hemmi;Katsuaki Hoshino

  • Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.

    Hiroaki Hemmi;Tsuneyasu Kaisho;Osamu Takeuchi;Shintaro Sato

  • IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

    Taro Kawai;Ken Takahashi;Ken Takahashi;Shintaro Sato;Cevayir Coban

  • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.

    Tatsuya Saitoh;Naonobu Fujita;Myoung Ho Jang;Satoshi Uematsu

  • Cell type-specific involvement of RIG-I in antiviral response

    Hiroki Kato;Shintaro Sato;Mitsutoshi Yoneyama;Masahiro Yamamoto

  • TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

    Michaela U. Gack;Young C. Shin;Chul Hyun Joo;Chul Hyun Joo;Tomohiko Urano;Tomohiko Urano

  • Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

    Hiroki Kato;Osamu Takeuchi;Eriko Mikamo-Satoh;Eriko Mikamo-Satoh;Reiko Hirai

  • Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins

    Osamu Takeuchi;Shintaro Sato;Takao Horiuchi;Katsuaki Hoshino

  • Discrimination of bacterial lipoproteins by Toll-like receptor 6

    Osamu Takeuchi;Taro Kawai;Peter F. Mühlradt;Michael Morr

  • Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.

    Masahiro Yamamoto;Shintaro Sato;Kiyotoshi Mori;Katsuaki Hoshino

  • Innate immunity to virus infection.

    Osamu Takeuchi;Shizuo Akira

  • Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes.

    Taro Kawai;Osamu Takeuchi;Takashi Fujita;Jun-ichiro Inoue

  • TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

    Masahiro Yamamoto;Shintaro Sato;Hiroaki Hemmi;Satoshi Uematsu

Frequent Co-Authors

Shizuo Akira
Shizuo Akira Osaka University
Taro Kawai
Taro Kawai Nara Institute of Science and Technology
Kiyoshi Takeda
Kiyoshi Takeda Osaka University
Satoshi Uematsu
Satoshi Uematsu Osaka Metropolitan University
Shintaro Sato
Shintaro Sato Osaka University
Katsuaki Hoshino
Katsuaki Hoshino Kagawa University
Masahiro Yamamoto
Masahiro Yamamoto Osaka University
Ken J. Ishii
Ken J. Ishii University of Tokyo
Tatsuya Saitoh
Tatsuya Saitoh Osaka University
Tsuneyasu Kaisho
Tsuneyasu Kaisho Wakayama Medical University

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