World's Best Scientists 2026 revealed!
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Microbiology
Japan
2025

D-Index & Metrics

Immunology

D-Index
110
Citations
46908
World Ranking
501
National Ranking
16

Research.com Recognitions

  • 2025 - Research.com Microbiology in Japan Leader Award

Overview

Kensuke Miyake is affiliated with the University of Tokyo in Japan and has contributed extensively to research in immunology, microbiology, medicine, and molecular biology. Their scholarly work spans several interconnected fields with a particular focus on immune responses, inflammasomes, and related cellular mechanisms.

The scientist's research covers multiple main fields of study including:

  • Immunology and Microbiology
  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these broader areas, Miyake's work further addresses key subfields:

  • Immunology
  • Molecular Biology
  • Physiology
  • Infectious Diseases
  • Epidemiology

The primary research topics can be summarized as follows:

  • Immune Response and Inflammation
  • Interferon and Immune Responses
  • Inflammasome and Immune Disorders
  • Immune Cells in Cancer
  • Immune Cell Function and Interaction
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Endoplasmic Reticulum Stress and Disease

Miyake has published in various venues, with notable frequency in:

  • International Immunology
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • The Journal of Experimental Medicine

Recent papers by Kensuke Miyake include:

  • "STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes" (2023, Nature Cell Biology)
  • "Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus" (2022, Nature Immunology)
  • "Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors" (2021, Nature Communications)
  • "Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome" (2023, Nature)
  • "Anti-TLR7 Antibody Protects Against Lupus Nephritis in NZBWF1 Mice by Targeting B Cells and Patrolling Monocytes" (2021, Frontiers in Immunology)

Frequent collaborators in Miyake's studies include:

  • Ryutaro Fukui
  • Takuma Shibata
  • Ryota Sato
  • Yusuke Murakami
  • Ryosuke Hiranuma

Best Publications

  • MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

    Rintaro Shimazu;Sachiko Akashi;Hirotaka Ogata;Yoshinori Nagai

  • Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

    Christian C. Termeer;Frauke Benedix;Jonathon Sleeman;Christina Fieber

  • Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

    Nobuhiko Kayagaki;Michael T. Wong;Irma B. Stowe;Sree Ranjani Ramani

  • Essential role of MD-2 in LPS responsiveness and TLR4 distribution.

    Yoshinori Nagai;Sachiko Akashi;Masakazu Nagafuku;Masato Ogata

  • Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression

    Fumiko Nomura;Sachiko Akashi;Yoshimitsu Sakao;Shintaro Sato

  • Role of the Toll-like Receptor 4/NF-κB Pathway in Saturated Fatty Acid-induced Inflammatory Changes in the Interaction Between Adipocytes and Macrophages

    Takayoshi Suganami;Kanami Tanimoto-Koyama;Junko Nishida;Michiko Itoh

  • Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition.

    K Miyake;C B Underhill;J Lesley;P W Kincade

  • Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation.

    Martha Triantafilou;Kensuke Miyake;Douglas T. Golenbock;Douglas T. Golenbock;Kathy Triantafilou

  • Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia.

    Takuya Matsunaga;Naofumi Takemoto;Tsutomu Sato;Rishu Takimoto

  • The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

    Sachie Hiratsuka;Akira Watanabe;Yoshiko Sakurai;Sachiko Akashi-Takamura

  • Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors.

    Kensuke Miyake

  • Cutting Edge: Cell Surface Expression and Lipopolysaccharide Signaling Via the Toll-Like Receptor 4-MD-2 Complex on Mouse Peritoneal Macrophages

    Sachiko Akashi;Rintaro Shimazu;Hirotaka Ogata;Yoshinori Nagai

  • Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling.

    Misako Matsumoto;Satomi Kikkawa;Masayoshi Kohase;Kensuke Miyake

  • Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

    Kosei Eguchi;Ichiro Manabe;Yumiko Oishi-Tanaka;Mitsuru Ohsugi

  • Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa.

    Umeharu Ohto;Koichi Fukase;Kensuke Miyake;Yoshinori Satow

  • Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2 Higher Affinity than That with MD-2 or CD14

    Sachiko Akashi;Shin-ichiroh Saitoh;Yasutaka Wakabayashi;Takane Kikuchi

  • Mouse Toll-like Receptor 4·MD-2 Complex Mediates Lipopolysaccharide-mimetic Signal Transduction by Taxol

    Kiyoshi Kawasaki;Sachiko Akashi;Rintaro Shimazu;Takashi Yoshida

  • Toll-Like Receptor 4 Expression Is Required to Control Chronic Mycobacterium tuberculosis Infection in Mice

    Brian Abel;Nathalie Thieblemont;Nathalie Thieblemont;Valerie J. F. Quesniaux;Najmeeyah Brown

  • Cutting edge: Lipopolysaccharide induces physical proximity between CD14 and Toll-like receptor 4 (TLR4) prior to nuclear translocation of NF-κB

    Qingqi Jiang;Sachiko Akashi;Kensuke Miyake;Howard R. Petty

  • Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain

    Takashi Shichita;Eiichi Hasegawa;Akihiro Kimura;Rimpei Morita

  • The hyaluronate receptor is a member of the CD44 (H-CAM) family of cell surface glycoproteins.

    M Culty;K Miyake;P W Kincade;E Sikorski

  • Toll-like Receptor 4, but Not Toll-Like Receptor 2, Is a Signaling Receptor for Escherichia and Salmonella Lipopolysaccharides

    Richard I. Tapping;Sachiko Akashi;Kensuke Miyake;Paul J. Godowski

Frequent Co-Authors

Toshiyuki Shimizu
Toshiyuki Shimizu University of Tokyo
Shizuo Akira
Shizuo Akira Osaka University
Kiyoshi Takatsu
Kiyoshi Takatsu University of Toyama
Koichi Fukase
Koichi Fukase Osaka University
Toshiyuki Hamaoka
Toshiyuki Hamaoka Osaka University
Eicke Latz
Eicke Latz German Rheumatism Research Centre
Kiyoshi Takeda
Kiyoshi Takeda Osaka University
Tsuneyasu Kaisho
Tsuneyasu Kaisho Wakayama Medical University
Osamu Takeuchi
Osamu Takeuchi Kyoto University
Nobuaki Yoshida
Nobuaki Yoshida University of Tokyo

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