H-Index & Metrics Best Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 129 Citations 75,263 388 World Ranking 184 National Ranking 1

Research.com Recognitions

Awards & Achievements

2016 - Fellow of the Royal Society, United Kingdom

2012 - Gold Medal, Royal Irish Academy Life Sciences

2004 - Member of the Royal Irish Academy

Member of the European Molecular Biology Organization (EMBO)


What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Immune system

His primary areas of study are Cell biology, Immunology, Signal transduction, Receptor and Innate immune system. Luke A. J. O'Neill has included themes like Glycolysis, Warburg effect, Biochemistry and Toll-like receptor in his Cell biology study. As a part of the same scientific study, Luke A. J. O'Neill usually deals with the Immunology, concentrating on Neuroscience and frequently concerns with Cytokines metabolism.

His biological study spans a wide range of topics, including Molecular biology, Transcription factor and Interleukin-1 Receptor-Associated Kinases. His work deals with themes such as Golgi apparatus and Cytokine, which intersect with Receptor. His Innate immune system research incorporates themes from Disease and Virology.

His most cited work include:

  • The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling (1982 citations)
  • Succinate is an inflammatory signal that induces IL-1β through HIF-1α (1591 citations)
  • Negative regulation of Toll-like receptor-mediated immune responses (1312 citations)

What are the main themes of his work throughout his whole career to date?

Luke A. J. O'Neill spends much of his time researching Cell biology, Immunology, Receptor, Signal transduction and Inflammation. His Cell biology research includes themes of Glycolysis, Transcription factor and Biochemistry. His studies in Transcription factor integrate themes in fields like Molecular biology and Cancer research.

His research in Innate immune system, Inflammasome, Immune system, Immunity and Cytokine are components of Immunology. His research in Receptor is mostly focused on Toll-like receptor. His work deals with themes such as Kinase and TRIF, which intersect with Signal transduction.

He most often published in these fields:

  • Cell biology (37.31%)
  • Immunology (32.95%)
  • Receptor (22.54%)

What were the highlights of his more recent work (between 2014-2021)?

  • Cell biology (37.31%)
  • Immunology (32.95%)
  • Inflammation (18.37%)

In recent papers he was focusing on the following fields of study:

Luke A. J. O'Neill mainly investigates Cell biology, Immunology, Inflammation, Inflammasome and Immune system. His Cell biology research is mostly focused on the topic Signal transduction. Luke A. J. O'Neill works mostly in the field of Immunology, limiting it down to topics relating to Receptor and, in certain cases, Phosphorylation.

His Inflammation study also includes fields such as

  • Tumor necrosis factor alpha most often made with reference to Lipopolysaccharide,
  • Oxidative stress that connect with fields like Reactive oxygen species. His Immune system research integrates issues from Cell metabolism, Macrophage and Function. His Immunity research incorporates elements of Neuroscience and Vaccination.

Between 2014 and 2021, his most popular works were:

  • A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases (1061 citations)
  • Trained immunity: A program of innate immune memory in health and disease (1005 citations)
  • A guide to immunometabolism for immunologists (974 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Cytokine

His scientific interests lie mostly in Cell biology, Immunology, Inflammation, Inflammasome and Innate immune system. His Cell biology study combines topics from a wide range of disciplines, such as Glycolysis, Immune system, Immunity, Proinflammatory cytokine and Citric acid cycle. His Immunology research includes themes of Disease, Cellular differentiation and Intracellular.

His work carried out in the field of Inflammation brings together such families of science as Interleukin, Oxidative stress, In vivo and Bioinformatics. The Innate immune system study which covers Metabolic pathway that intersects with Macrophage polarization and Cellular metabolism. Luke A. J. O'Neill usually deals with Cytokine and limits it to topics linked to Signal transduction and Succinic acid.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

Luke A. J. O'Neill;Andrew G. Bowie.
Nature Reviews Immunology (2007)

2835 Citations

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

G. M. Tannahill;A. M. Curtis;J. Adamik;E. M. Palsson-McDermott.
Nature (2013)

1950 Citations

Negative regulation of Toll-like receptor-mediated immune responses

Foo Y. Liew;Damo Xu;Elizabeth K. Brint;Luke A. J. O'Neill.
Nature Reviews Immunology (2005)

1682 Citations

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Katherine A. Fitzgerald;Eva M. Palsson-McDermott;Andrew G. Bowie;Andrew G. Bowie;Caroline A. Jefferies.
Nature (2001)

1529 Citations

The History of Toll-like Receptors - Redefining Innate Immunity

Luke A. J. O'Neill;Douglas Golenbock;Andrew G. Bowie.
Nature Reviews Immunology (2013)

1509 Citations

Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4

Eva M Pålsson-McDermott;Luke A J O'Neill.
Immunology (2004)

1307 Citations

A guide to immunometabolism for immunologists

Luke A. J. O'Neill;Rigel J. Kishton;Jeff Rathmell.
Nature Reviews Immunology (2016)

1184 Citations

Resolution of inflammation: state of the art, definitions and terms.

Charles N. Serhan;Sue D. Brain;Christopher D. Buckley;Derek W. Gilroy.
The FASEB Journal (2006)

1152 Citations

NF-kB: a crucial transcription factor for glial and neuronal cell function

L. ONeill;Christian Kaltschmidt.
Trends in Neurosciences (1997)

1116 Citations

Oxidative stress and nuclear factor-κB activation: A reassessment of the evidence in the light of recent discoveries

Andrew Bowie;Luke A.J O’Neill.
Biochemical Pharmacology (2000)

1082 Citations

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