2026 Luke A. J. O'Neill: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	159	84	81	1	1	519	113183

Research.com Recognitions

2026 - Research.com Immunology in Ireland Leader Award
2025 - Research.com Immunology in Ireland Leader Award
2023 - Research.com Biology and Biochemistry in Ireland Leader Award
2022 - Research.com Biology and Biochemistry in Ireland Leader Award
2016 - Fellow of the Royal Society, United Kingdom
2012 - Gold Medal, Royal Irish Academy Life Sciences
2004 - Member of the Royal Irish Academy
Member of the European Molecular Biology Organization (EMBO)
Member of the European Molecular Biology Organization (EMBO)

Overview

Luke A. J. O'Neill is affiliated with Trinity College Dublin in Ireland. Their research focuses broadly on immunology, microbiology, biochemistry, genetics, molecular biology, and medicine. Their work encompasses several subfields including immunology, molecular biology, epidemiology, infectious diseases, and genetics.

The scientist's research primarily addresses topics such as immune cells in cancer, inflammasome and immune disorders, interferon and immune responses, immune cell function and interaction, immune response and inflammation, immune responses and vaccinations, and IL-33, ST2, and ILC pathways.

Frequent co-authors collaborating with Luke A. J. O'Neill include Alexander Hooftman, Dylan G. Ryan, Tristram A.J. Ryan, Emily A. Day, and Anne F. McGettrick.

Their publications often appear in leading scientific journals. Frequent publication venues include:

Nature Immunology
Cell Metabolism
Nature Communications
Nature
Cells

Significant recent papers include:

The Role of HIF in Immunity and Inflammation, 2020, Cell Metabolism
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation, 2020, Cell Metabolism
BCG-induced trained immunity: can it offer protection against COVID-19?, 2020, Nature Reviews Immunology
Trained immunity, tolerance, priming and differentiation: distinct immunological processes, 2020, Nature Immunology
Targeting immunometabolism as an anti-inflammatory strategy, 2020, Cell Research

Luke A. J. O'Neill's research has received recognition in the form of several awards. These include being a Fellow of the Royal Society, United Kingdom, since 2016; receiving the Gold Medal from the Royal Irish Academy in Life Sciences in 2012; membership in the Royal Irish Academy since 2004; and election to the European Molecular Biology Organization (EMBO).

Best Publications

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

G. M. Tannahill;A. M. Curtis;J. Adamik;E. M. Palsson-McDermott

4066
Citations
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

Luke A. J. O'Neill;Andrew G. Bowie

3397
Citations
A guide to immunometabolism for immunologists

Luke A. J. O'Neill;Rigel J. Kishton;Jeff Rathmell

2965
Citations
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C Coll;Avril A B Robertson;Jae Jin Chae;Sarah C Higgins

2805
Citations
Trained immunity: A program of innate immune memory in health and disease

Mihai G. Netea;Leo A. B. Joosten;Eicke Latz;Kingston H. G. Mills

2572
Citations
mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

Shih-Chin Cheng;Jessica Quintin;Robert A. Cramer;Kelly M. Shepardson

2188
Citations
The History of Toll-like Receptors - Redefining Innate Immunity

Luke A. J. O'Neill;Douglas Golenbock;Andrew G. Bowie

2137
Citations
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

Evanna L. Mills;Beth Kelly;Angela Logan;Ana S.H. Costa

2135
Citations
Human polymorphism at microRNAs and microRNA target sites.

Liuqing Yang;Chunru Lin;Chunyu Jin;Joy C. Yang

2133
Citations
Negative regulation of Toll-like receptor-mediated immune responses

Foo Y. Liew;Damo Xu;Elizabeth K. Brint;Luke A. J. O'Neill

1882
Citations
Metabolic reprogramming in macrophages and dendritic cells in innate immunity

Beth Kelly;Luke A J O'Neill

1845
Citations
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Evanna L Mills;Dylan G Ryan;Hiran A Prag;Dina Dikovskaya

1783
Citations
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Katherine A. Fitzgerald;Eva M. Palsson-McDermott;Andrew G. Bowie;Andrew G. Bowie;Caroline A. Jefferies

1679
Citations
Immunometabolism governs dendritic cell and macrophage function

Luke A.J. O’Neill;Edward J. Pearce

1623
Citations
Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4

Eva M Pålsson-McDermott;Luke A J O'Neill

1583
Citations
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Seth L Masters;Aisling Dunne;Shoba L Subramanian;Rebecca L Hull

1468
Citations
Resolution of inflammation: state of the art, definitions and terms.

Charles N. Serhan;Sue D. Brain;Christopher D. Buckley;Derek W. Gilroy

1372
Citations
NF-kB: a crucial transcription factor for glial and neuronal cell function

L. ONeill;Christian Kaltschmidt

1359
Citations
Metabolism of inflammation limited by AMPK and pseudo-starvation

Luke A. J. O'Neill;D. Grahame Hardie

1259
Citations
Mitochondria are the powerhouses of immunity.

Evanna L Mills;Beth Kelly;Luke A J O'Neill

1245
Citations
Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

Frederick J Sheedy;Eva Palsson-McDermott;Elizabeth J Hennessy;Cara Martin

1204
Citations
Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.

Andrew Bowie;Luke A.J O’Neill

1142
Citations

Frequent Co-Authors

Mark E. Cooper Monash University

Andrew G. Bowie Trinity College Dublin

Katherine A. Fitzgerald University of Massachusetts Chan Medical School

Mihai G. Netea Radboud University

Kingston H. G. Mills Trinity College Dublin

Ramnik J. Xavier Broad Institute

Seth L. Masters Hudson Institute of Medical Research

Hugh J. Byrne Technological University Dublin

Kate Schroder University of Queensland

Eicke Latz German Rheumatism Research Centre

External Links

Wikipedia of Luke A. J. O'Neill Personal website of Luke A. J. O'Neill

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