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Immunology

D-Index
70
Citations
30418
World Ranking
2369
National Ranking
95

Overview

Seth L. Masters is affiliated with the Walter and Eliza Hall Institute of Medical Research in Australia. Their research spans multiple fields including Immunology and Microbiology, Biochemistry, Genetics and Molecular Biology, and Medicine, with a significant focus on Immunology, Molecular Biology, Oncology, Genetics, and Neurology.

The main topics covered in their research contributions include:

  • Inflammasome and immune disorders
  • Interferon and immune responses
  • Immune Cell Function and Interaction
  • Immune Response and Inflammation
  • RNA regulation and disease
  • Ubiquitin and proteasome pathways
  • Immunodeficiency and Autoimmune Disorders

Seth L. Masters has published extensively across various venues with frequent publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Experimental Medicine
  • Nature Immunology
  • Nature Communications
  • Nature reviews. Immunology

Selected recent papers include:

  • "TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS," 2020, Cell
  • "TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells," 2020, Cell Reports
  • "Constitutive immune mechanisms: mediators of host defence and immune regulation," 2020, Nature reviews. Immunology
  • "Organellar homeostasis and innate immune sensing," 2022, Nature reviews. Immunology
  • "ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome," 2022, Science

Frequent co-authors include:

  • Katja Hrovat-Schaale
  • Chien-Hsiung Yu
  • Sophia Davidson
  • Cassandra R. Harapas
  • Pawat Laohamonthonkul

Best Publications

  • Succinate is an inflammatory signal that induces IL-1β through HIF-1α

    G. M. Tannahill;A. M. Curtis;J. Adamik;E. M. Palsson-McDermott

  • A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

    Rebecca C Coll;Avril A B Robertson;Jae Jin Chae;Sarah C Higgins

  • Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

    Seth L Masters;Aisling Dunne;Shoba L Subramanian;Rebecca L Hull

  • STAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus

    Elaine F. Remmers;Robert M. Plenge;Annette T. Lee;Robert R. Graham;Robert R. Graham

  • Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

    Seth L. Masters;Anna Simon;Ivona Aksentijevich;Daniel L. Kastner

  • An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

    Ivona Aksentijevich;Seth L. Masters;Polly J. Ferguson;Paul Dancey

  • NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.

    Auvro R. Mridha;Alexander Wree;Alexander Wree;Avril A.B. Robertson;Matthew M. Yeh

  • TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

    Chien-Hsiung Yu;Chien-Hsiung Yu;Sophia Davidson;Sophia Davidson;Cassandra R. Harapas;Cassandra R. Harapas;James B. Hilton;James B. Hilton

  • RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

    Kate E. Lawlor;Nufail Khan;Alison Mildenhall;Motti Gerlic

  • RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

    James A Rickard;James A Rickard;Joanne A O'Donnell;Joanne A O'Donnell;Joseph M Evans;Joseph M Evans;Najoua Lalaoui;Najoua Lalaoui

  • The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells

    Ajithkumar Vasanthakumar;Kazuyo Moro;Annie Xin;Yang Liao

  • Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity

    Prabhakara Reddy Nagareddy;Michael J Kraakman;Seth L Masters;Roslynn A Stirzaker

  • Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β Production

    Moritz Haneklaus;Motti Gerlic;Mariola Kurowska-Stolarska;Ashleigh-Ann Rainey

  • miR‐223: infection, inflammation and cancer

    M. Haneklaus;M. Gerlic;M. Gerlic;Luke A. J. O'Neill;S.L. Masters;S.L. Masters

  • Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

    Stephanie A. Conos;Stephanie A. Conos;Kaiwen W Chen;Dominic De Nardo;Dominic De Nardo;Hideki Hara

  • Homeostasis-altering molecular processes as mechanisms of inflammasome activation

    Adrian Liston;Seth L. Masters

  • Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

    Graeme I. Lancaster;Graeme I. Lancaster;Katherine G. Langley;Katherine G. Langley;Nils Anton Berglund;Helene L. Kammoun

  • TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells.

    Katherine R. Balka;Katherine R. Balka;Katherine R. Balka;Cynthia Louis;Cynthia Louis;Tahnee L. Saunders;Amber M. Smith

  • Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation

    Franklin L. Zhong;Ons Mamaï;Lorenzo Sborgi;Lobna Boussofara

  • NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.

    Paul J. Baker;Paul J. Baker;Dave Boucher;Damien Bierschenk;Christina Tebartz

  • NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells

    Seth L. Masters;Motti Gerlic;Motti Gerlic;Donald Metcalf;Donald Metcalf;Simon Preston;Simon Preston

  • Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

    Viola Neudecker;Viola Neudecker;Moritz Haneklaus;Owen Jensen;Ludmila Khailova

Frequent Co-Authors

Ian P. Wicks
Ian P. Wicks Walter and Eliza Hall Institute of Medical Research
Benjamin T. Kile
Benjamin T. Kile University of Adelaide
Sandra E. Nicholson
Sandra E. Nicholson Walter and Eliza Hall Institute of Medical Research
James E. Vince
James E. Vince Walter and Eliza Hall Institute of Medical Research
Daniel L. Kastner
Daniel L. Kastner National Institutes of Health
Warren S. Alexander
Warren S. Alexander Walter and Eliza Hall Institute of Medical Research
Jian-Guo Zhang
Jian-Guo Zhang Beijing Institute for Brain Disorders
Kate E. Lawlor
Kate E. Lawlor Hudson Institute of Medical Research
Eicke Latz
Eicke Latz German Rheumatism Research Centre
Donald Metcalf
Donald Metcalf Walter and Eliza Hall Institute of Medical Research

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