The scientist’s investigation covers issues in Cell biology, Signal transduction, Molecular biology, Suppressor of cytokine signalling and Immunology. The concepts of his Cell biology study are interwoven with issues in Acquired immune system, Spectrin, Ligand, Dendritic cell and Actin cytoskeleton. His study in Signal transduction is interdisciplinary in nature, drawing from both RIPK1, Phosphorylation and Leukemia inhibitory factor.
His research integrates issues of Multiprotein complex, Kinase and Programmed cell death, Necroptosis in his study of Phosphorylation. His Molecular biology study combines topics in areas such as 5-HT5A receptor, Common gamma chain, Interleukin-21 receptor, Interleukin 1 receptor, type I and Glycoprotein 130. His Suppressor of cytokine signalling study combines topics from a wide range of disciplines, such as Suppressor of cytokine signaling 1, Cytokine, Genetically modified mouse and STAT protein.
The scientist’s investigation covers issues in Cell biology, Signal transduction, Molecular biology, Immunology and Leukemia inhibitory factor. A large part of his Cell biology studies is devoted to Suppressor of cytokine signalling. His Signal transduction research integrates issues from Programmed cell death and Phosphorylation.
His study explores the link between Molecular biology and topics such as Receptor that cross with problems in Stereochemistry. In the subject of general Immunology, his work in Autoimmunity, CD8 and Interferon is often linked to Systemic lupus erythematosus and Lupus erythematosus, thereby combining diverse domains of study. His Leukemia inhibitory factor research is multidisciplinary, incorporating elements of Endocrinology, Glycoprotein 130, Internal medicine and Trophoblast.
His primary areas of investigation include Cell biology, Cancer research, Immunology, Leukemia inhibitory factor and CD8. His Cell biology research incorporates elements of Cellular differentiation, Immune system, Antigen, Receptor and Ubiquitin ligase. The Cancer research study combines topics in areas such as Missense mutation, Heterozygote advantage, Compound heterozygosity and Programmed cell death, Necroptosis.
His Leukemia inhibitory factor research is multidisciplinary, relying on both Treatment strategy, Trophoblast, Glycoprotein 130 and Ectopic pregnancy. His research in Signal transduction intersects with topics in Cell migration, Reelin, DAB1, Cerebral cortex and Phosphorylation. Jian-Guo Zhang combines subjects such as Suppressor of cytokine signaling 1, SOCS3, Suppressor of cytokine signalling and Cytokine with his study of Cytotoxic T cell.
Cell biology, Immunology, Cancer research, Cell and Immunotherapy are his primary areas of study. He is interested in Signal transduction, which is a field of Cell biology. His Signal transduction study integrates concerns from other disciplines, such as Transgene, Autoimmunity, Bcl-2 family and Gene knockdown.
His work on T cell as part of general Immunology research is frequently linked to Pregnancy-associated plasma protein A, thereby connecting diverse disciplines of science. His studies deal with areas such as Mutation, Missense mutation, Heterozygote advantage and Programmed cell death, Necroptosis as well as Cancer research. His biological study spans a wide range of topics, including Janus kinase 1, CISH and Interferon gamma.
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SOCS3 negatively regulates IL-6 signaling in vivo.
Ben A Croker;Danielle L Krebs;Jian-Guo Zhang;Sam Wormald.
Nature Immunology (2003)
The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
James M. Murphy;Peter E. Czabotar;Peter E. Czabotar;Joanne M. Hildebrand;Joanne M. Hildebrand;Isabelle S. Lucet.
Immunity (2013)
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
Jian Guo Zhang;Alison Farley;Sandra E. Nicholson;Tracy A. Willson.
Proceedings of the National Academy of Sciences of the United States of America (1999)
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
Sandra E. Nicholson;David De Souza;Louis J. Fabri;Jason Corbin.
Proceedings of the National Academy of Sciences of the United States of America (2000)
Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor
Douglas J. Hilton;Jian-Guo Zhang;Donald Metcalf;Warren S. Alexander.
Proceedings of the National Academy of Sciences of the United States of America (1996)
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction
Sandra E. Nicholson;Tracy A. Willson;Alison Farley;Robyn Starr.
The EMBO Journal (1999)
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
Lorraine A. O Reilly;Lin Tai;Lily Lee;Elizabeth A. Kruse;Elizabeth A. Kruse.
Nature (2009)
Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity
Jennifer Eve Fenner;Robyn J Starr;Ann L Cornish;Ann L Cornish;Jian-Guo Zhang.
Nature Immunology (2006)
LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival
Helmut Butzkueven;Jian Guo Zhang;Merja Soilu-Hanninen;Hubertus Hochrein.
Nature Medicine (2002)
The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments
Jian Guo Zhang;Jian Guo Zhang;Peter E. Czabotar;Peter E. Czabotar;Antonia N. Policheni;Antonia N. Policheni;Irina Caminschi;Irina Caminschi;Irina Caminschi.
Immunity (2012)
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Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
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