World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
50
Citations
9726
World Ranking
2566
National Ranking
60

Overview

Andrew I. Webb is affiliated with the Walter and Eliza Hall Institute of Medical Research in Australia. Their research spans multiple disciplines within the fields of Biochemistry, Genetics, Molecular Biology, and Medicine. The scientist has contributed to 79 publications in Biochemistry, Genetics and Molecular Biology and 46 in Medicine, with significant focus on several subfields such as Molecular Biology, Immunology, Spectroscopy, Oncology, and Hematology.

Their main research topics include:

  • Advanced Proteomics Techniques and Applications
  • Metabolomics and Mass Spectrometry Studies
  • Mass Spectrometry Techniques and Applications
  • Cell death mechanisms and regulation
  • Interferon and immune responses
  • Immunotherapy and Immune Responses
  • Extracellular vesicles in disease

Andrew I. Webb has authored several recent papers in renowned journals, highlighting ongoing contributions to the scientific community. Key publications include:

  • "Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition," published in 2021 in Molecular Cell
  • "Person-Specific Biomolecular Coronas Modulate Nanoparticle Interactions with Immune Cells in Human Blood," published in 2020 in ACS Nano
  • "ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism," published in 2020 in Nature Cell Biology
  • "Cytotoxic T cells swarm by homotypic chemokine signalling," published in 2020 in eLife
  • "Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis," published in 2021 in Nature Communications

The frequent co-authors collaborating with Andrew I. Webb include:

  • Jarrod J. Sandow
  • Laura F. Dagley
  • James M. Murphy
  • Giuseppe Infusini
  • Samuel N. Young

Andrew I. Webb has published extensively in several venues with multiple works appearing in bioRxiv (Cold Spring Harbor Laboratory), where they have 13 publications. Other notable journals featuring their work include Nature Communications (3 publications), Nature Cell Biology (2 publications), The EMBO Journal (2 publications), and the Journal of Neuro-Oncology (2 publications).

Best Publications

  • The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

    James M. Murphy;Peter E. Czabotar;Peter E. Czabotar;Joanne M. Hildebrand;Joanne M. Hildebrand;Isabelle S. Lucet

  • Linear ubiquitination prevents inflammation and regulates immune signalling

    Bjã¶rn Gerlach;Stefanie M. Cordier;Anna C. Schmukle;Christoph H. Emmerich;Christoph H. Emmerich

  • Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma

    J S Waters;A Webb;D Cunningham;P A Clarke

  • Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

    Joanne M. Hildebrand;Maria C. Tanzer;Isabelle S. Lucet;Isabelle S. Lucet;Samuel N. Young

  • CIS is a potent checkpoint in NK cell–mediated tumor immunity

    Rebecca B. Delconte;Tatiana B Kolesnik;Laura F. Dagley;Laura F. Dagley;Jai Rautela;Jai Rautela

  • Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation

    Seth L. Masters;Seth L. Masters;Vasiliki Lagou;Isabelle Jéru;Isabelle Jéru;Paul J. Baker;Paul J. Baker

  • A type III effector antagonizes death receptor signalling during bacterial gut infection

    Jaclyn S Pearson;Cristina Giogha;Sze Ying Ong;Catherine Lydia Kennedy

  • EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

    Jaclyn S. Pearson;Cristina Giogha;Sabrina Mühlen;Ueli Nachbur

  • Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations.

    Stephen John Turner;Katherine Kedzierska;Helen Komodromou;Nicole Louise La Gruta

  • Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

    Emma J. Petrie;Emma J. Petrie;Jarrod J. Sandow;Jarrod J. Sandow;Annette V. Jacobsen;Annette V. Jacobsen;Brian J. Smith

  • A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

    Ueli Nachbur;Che A Stafford;Aleksandra Bankovacki;Yifan Zhan

  • VDAC2 enables BAX to mediate apoptosis and limit tumor development.

    Hui San Chin;Hui San Chin;Mark X. Li;Mark X. Li;Iris K. L. Tan;Robert L. Ninnis;Robert L. Ninnis

  • A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

    Jérôme Le Nours;Jérôme Le Nours;Nicholas A. Gherardin;Nicholas A. Gherardin;Sri H. Ramarathinam;Wael Awad

  • Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop

    Maria C Tanzer;Maria C Tanzer;Anne Tripaydonis;Anne Tripaydonis;Andrew I Webb;Andrew I Webb;Samuel N Young

  • Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase.

    Azadeh Seidi;Linden S Muellner-Wong;Esther Rajendran;Edwin T Tjhin

  • Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

    Simon J. Hogg;Simon J. Hogg;Olga Motorna;Leonie A. Cluse;Timothy M. Johanson;Timothy M. Johanson

  • Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3.

    Emma J. Petrie;Emma J. Petrie;Jarrod J. Sandow;Jarrod J. Sandow;Wil I.L. Lehmann;Wil I.L. Lehmann;Lung-Yu Liang;Lung-Yu Liang

  • Structure of Plasmodium falciparum Rh5–CyRPA–Ripr invasion complex

    Wilson Wong;Wilson Wong;Rick Huang;Sebastien Menant;Chuan Hong

  • The Structure of H-2Kb and Kbm8 Complexed to a Herpes Simplex Virus Determinant: Evidence for a Conformational Switch That Governs T Cell Repertoire Selection and Viral Resistance

    Andrew Ian Webb;Natalie A Borg;Michelle Anne Dunstone;Lars Kjer-Nielsen

  • Familial Autoinflammation with Neutrophilic Dermatosis Reveals a Novel Regulatory Mechanism of Pyrin Activation

    P. J. Baker;V. Lagou;I. Jeru;L. Van Eyck

Frequent Co-Authors

James M. Murphy
James M. Murphy Walter and Eliza Hall Institute of Medical Research
John Silke
John Silke Walter and Eliza Hall Institute of Medical Research
Peter E. Czabotar
Peter E. Czabotar Walter and Eliza Hall Institute of Medical Research
Anthony W. Purcell
Anthony W. Purcell Monash University
Jamie Rossjohn
Jamie Rossjohn Monash University
Sandra E. Nicholson
Sandra E. Nicholson Walter and Eliza Hall Institute of Medical Research
Christopher J. Tonkin
Christopher J. Tonkin Walter and Eliza Hall Institute of Medical Research
Nicos A. Nicola
Nicos A. Nicola Walter and Eliza Hall Institute of Medical Research
Grant Dewson
Grant Dewson Walter and Eliza Hall Institute of Medical Research
Warren S. Alexander
Warren S. Alexander Walter and Eliza Hall Institute of Medical Research

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