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Biology and Biochemistry

D-Index
42
Citations
8165
World Ranking
19467
National Ranking
581

Overview

Christopher J. Tonkin is affiliated with the Walter and Eliza Hall Institute of Medical Research in Australia. Their research spans several interconnected fields including immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology.

The scientist has contributed extensively to the study of parasitology, epidemiology, molecular biology, public health, environmental and occupational health, and virology. These subfields represent the disciplinary breadth of their work.

Key research topics addressed by Christopher J. Tonkin include:

  • Toxoplasma gondii Research Studies
  • Herpesvirus Infections and Treatments
  • Parasitic Infections and Diagnostics
  • Cytomegalovirus and herpesvirus research
  • Autophagy in Disease and Therapy
  • Infectious Encephalopathies and Encephalitis
  • HIV Research and Treatment

Their publications have appeared in a variety of scientific journals, with frequent contributions to bioRxiv (Cold Spring Harbor Laboratory), Cell Host & Microbe, PLoS Biology, Journal of Neuroinflammation, and Cell.

Notable recent papers authored or coauthored by Christopher J. Tonkin include:

  • "TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS" (2020), published in Cell
  • "Pathogenic Infection in Male Mice Changes Sperm Small RNA Profiles and Transgenerationally Alters Offspring Behavior" (2020), published in Cell Reports
  • "Direct Nanopore Sequencing of mRNA Reveals Landscape of Transcript Isoforms in Apicomplexan Parasites" (2021), published in mSystems
  • "Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT" (2021), published in Science Immunology
  • "Depletion of a Toxoplasma porin leads to defects in mitochondrial morphology and contacts with the endoplasmic reticulum" (2021), published in Journal of Cell Science

They have collaborated frequently with the following coauthors:

  • Alessandro D. Uboldi
  • Kelly L. Rogers
  • Stuart A. Ralph
  • Simona Seizova
  • Mary-Louise Wilde

Best Publications

  • TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

    Chien-Hsiung Yu;Chien-Hsiung Yu;Sophia Davidson;Sophia Davidson;Cassandra R. Harapas;Cassandra R. Harapas;James B. Hilton;James B. Hilton

  • Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast.

    Stuart A. Ralph;Giel G. van Dooren;Ross F. Waller;Michael J. Crawford

  • Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum

    Bernardo J. Foth;Stuart A. Ralph;Christopher J. Tonkin;Nicole S. Struck

  • Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method

    Christopher J. Tonkin;Giel G. van Dooren;Timothy P. Spurck;Nicole S. Struck

  • The Molecular Basis of Erythrocyte Invasion by Malaria Parasites

    Alan F. Cowman;Alan F. Cowman;Christopher J. Tonkin;Christopher J. Tonkin;Wai Hong Tham;Wai Hong Tham;Manoj T. Duraisingh

  • Molecular Mechanism for Switching of P. falciparum Invasion Pathways into Human Erythrocytes

    Janine Stubbs;Ken M. Simpson;Tony Triglia;David Plouffe

  • Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum

    Giel G. van Dooren;Matthias Marti;Christopher J. Tonkin;Luciana M. Stimmler

  • Insensitivity to anti-müllerian hormone due to a mutation in the human anti-müllerian hormone receptor.

    S. Imbeaud;E. Faure;I. Lamarre;M.-G. Mattei

  • Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum.

    Christopher J Tonkin;Céline K Carret;Céline K Carret;Manoj T Duraisingh;Manoj T Duraisingh;Till S Voss

  • Mitochondrial Metabolism of Glucose and Glutamine Is Required for Intracellular Growth of Toxoplasma gondii

    James I. MacRae;Lilach Sheiner;Amsha Nahid;Christopher Tonkin

  • An Overexpression Screen of Toxoplasma gondii Rab-GTPases Reveals Distinct Transport Routes to the Micronemes

    Katrin Kremer;Dirk Kamin;Eva Rittweger;Jonathan Wilkes

  • Progressive Multifocal Leukoencephalopathy (PML) Development Is Associated With Mutations in JC Virus Capsid Protein VP1 That Change Its Receptor Specificity

    Leonid Gorelik;Carl Reid;Manuela Testa;Margot Brickelmaier

  • TgCDPK3 regulates calcium-dependent egress of Toxoplasma gondii from host cells.

    James M. McCoy;James M. McCoy;Lachlan Whitehead;Giel G. van Dooren;Christopher J. Tonkin;Christopher J. Tonkin

  • A Novel Family of Apicomplexan Glideosome-associated Proteins with an Inner Membrane-anchoring Role

    Hayley E Bullen;Christopher J. Tonkin;Rebecca A O'Donnell;Wai Hong Tham

  • A Malaria Parasite Formin Regulates Actin Polymerization and Localizes to the Parasite-Erythrocyte Moving Junction during Invasion

    Jake Baum;Christopher J. Tonkin;Aditya S. Paul;Melanie Rug

  • Sequencing and Analysis of JC Virus DNA From Natalizumab-Treated PML Patients

    Carl E. Reid;Huo Li;Gargi Sur;Paul Carmillo

  • Evidence for Golgi-independent transport from the early secretory pathway to the plastid in malaria parasites.

    Christopher J. Tonkin;Nicole S. Struck;Kylie A. Mullin;Luciana M. Stimmler

  • An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

    Michael J Coffey;Brad E Sleebs;Brad E Sleebs;Alessandro D Uboldi;Alessandro D Uboldi;Alexandra L Garnham;Alexandra L Garnham

  • Protein Targeting to the Malaria Parasite Plastid

    Christopher J. Tonkin;Ming Kalanon;Geoffrey I. McFadden

  • Toxoplasmosis: A pathway to neuropsychiatric disorders

    Shiraz Tyebji;Shiraz Tyebji;Shiraz Tyebji;Simona Seizova;Simona Seizova;Anthony J. Hannan;Anthony J. Hannan;Christopher J. Tonkin;Christopher J. Tonkin

Frequent Co-Authors

Alan F. Cowman
Alan F. Cowman Walter and Eliza Hall Institute of Medical Research
Geoffrey I. McFadden
Geoffrey I. McFadden University of Melbourne
Andrew I. Webb
Andrew I. Webb Walter and Eliza Hall Institute of Medical Research
Brendan S. Crabb
Brendan S. Crabb Monash University
Stuart A. Ralph
Stuart A. Ralph University of Melbourne
Paul R. Gilson
Paul R. Gilson Burnet Institute
Seth L. Masters
Seth L. Masters Hudson Institute of Medical Research
Brian J. Smith
Brian J. Smith QIMR Berghofer Medical Research Institute
Malcolm J. McConville
Malcolm J. McConville University of Melbourne
Anthony J. Hannan
Anthony J. Hannan Florey Institute of Neuroscience and Mental Health

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