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Malcolm J. McConville

Malcolm J. McConville

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Biology and Biochemistry
Australia
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
90
Citations
26625
World Ranking
2460
National Ranking
55

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Australia Leader Award

Overview

Malcolm J. McConville is affiliated with the University of Melbourne in Australia, with a primary focus on the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their research contributions span a broad range of topics within these domains, emphasizing studies on parasitic diseases and related biological mechanisms.

The main topics covered in their work include:

  • Trypanosoma species research and implications
  • Research on Leishmaniasis Studies
  • Toxoplasma gondii Research Studies
  • Malaria Research and Control
  • Metabolomics and Mass Spectrometry Studies
  • Mosquito-borne diseases and control
  • Parasitic Infections and Diagnostics

Frequent publication venues for their research are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Nature Communications
  • mBio
  • PLoS Pathogens

Among their published papers, notable recent works include:

  • The natural function of the malaria parasite's chloroquine resistance transporter, 2020, Nature Communications
  • Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria, 2023, Nature Communications
  • Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality, 2020, Nature Communications
  • Modulation of acyl-carnitines, the broad mechanism behindWolbachia-mediated inhibition of medically important flaviviruses inAedes aegypti, 2020, Proceedings of the National Academy of Sciences
  • Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization, 2022, Cell Reports

Malcolm J. McConville has collaborated extensively with several researchers, including:

  • David P. De Souza
  • Dedreia Tull
  • Eleanor Saunders
  • Brunda Nijagal
  • Saravanan Dayalan

Their work touches on subfields such as Public Health, Environmental and Occupational Health, Molecular Biology, Epidemiology, Parasitology, and Immunology. This range highlights a multidisciplinary approach to understanding infectious diseases, host-pathogen interactions, and immune responses.

Best Publications

  • MR1 presents microbial vitamin B metabolites to MAIT cells

    Lars Kjer-Nielsen;Onisha G Patel;Alexandra J Corbett;Jerome Le Nours;Jerome Le Nours

  • The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes.

    M J McConville;M A J Ferguson

  • Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

    Alison N Thorburn;Craig I McKenzie;Sj Shen;Dragana Stanley

  • Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells

    Annabell Bachem;Christina Makhlouf;Katrina J. Binger;David P. de Souza

  • CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells

    Louis Schofield;Malcolm J. McConville;Diana Hansen;A. Stewart Campbell

  • MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll‐like receptor 2 signaling

    Michael John de Veer;Joan Curtis;Tracey M Baldwin;Joseph A DiDonato

  • Developmental modification of lipophosphoglycan during the differentiation of Leishmania major promastigotes to an infectious stage.

    Malcolm J. McConville;Salvatore J. Turco;Michael A. J. Ferguson;David L. Sacks

  • Stage-specific adhesion of Leishmania promastigotes to the sandfly midgut.

    Paulo F. P. Pimenta;Salvatore J. Turco;Malcolm J. McConville;Phillip G. Lawyer

  • Glycosylphosphatidylinositol toxin of Plasmodium induces nitric oxide synthase expression in macrophages and vascular endothelial cells by a protein tyrosine kinase-dependent and protein kinase C-dependent signaling pathway.

    S D Tachado;P Gerold;M J McConville;T Baldwin

  • Developmental changes in the glycosylated phosphatidylinositols of Leishmania donovani. Characterization of the promastigote and amastigote glycolipids.

    M J McConville;J M Blackwell

  • Glycosylphosphatidylinositol toxin of Plasmodium up-regulates intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin expression in vascular endothelial cells and increases leukocyte and parasite cytoadherence via tyrosine kinase-dependent signal transduction.

    L Schofield;S Novakovic;P Gerold;R T Schwarz

  • Secretory Pathway of Trypanosomatid Parasites

    Malcolm J. McConville;Kylie A. Mullin;Steven C. Ilgoutz;Rohan D. Teasdale

  • Distinct Protein Classes Including Novel Merozoite Surface Antigens in Raft-like Membranes of Plasmodium falciparum

    Paul R. Sanders;Paul R. Sanders;Paul R. Gilson;Greg T. Cantin;Doron C. Greenbaum

  • Structures of the glycoinositolphospholipids from Leishmania major. A family of novel galactofuranose-containing glycolipids.

    M J McConville;S W Homans;J E Thomas-Oates;A Dell

  • Signal transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties.

    Souvenir D. Tachado;Peter Gerold;Ralph Schwarz;Suzanna Novakovic

  • Stage-specific binding of Leishmania donovani to the sand fly vector midgut is regulated by conformational changes in the abundant surface lipophosphoglycan.

    D. L. Sacks;P. F. P. Pimenta;M. J. Mcconville;P. Schneider

  • Living in a phagolysosome; metabolism of Leishmania amastigotes

    Malcolm J McConville;David P De Souza;Eleanor C Saunders;Vladimir A Likic

  • Structure of the lipophosphoglycan from Leishmania major.

    M. J. Mcconville;J. E. Thomas-Oates;M. A. J. Ferguson;S. W. Homans

  • The Leishmania-macrophage interaction: a metabolic perspective

    Thomas Naderer;Malcolm J McConville

  • Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum

    James I MacRae;Matthew Wa Dixon;Megan K Dearnley;Hwa H Chua

Frequent Co-Authors

Michael A. J. Ferguson
Michael A. J. Ferguson University of Dundee
Antony Bacic
Antony Bacic La Trobe University
Spencer J. Williams
Spencer J. Williams University of Melbourne
Ross L. Coppel
Ross L. Coppel Monash University
Peter J. Meikle
Peter J. Meikle Baker IDI Heart and Diabetes Institute
Ross F. Waller
Ross F. Waller University of Cambridge
Pascal Schneider
Pascal Schneider University of Lausanne
Christopher J. Tonkin
Christopher J. Tonkin Walter and Eliza Hall Institute of Medical Research
Darren J. Creek
Darren J. Creek Monash University
Emanuela Handman
Emanuela Handman Walter and Eliza Hall Institute of Medical Research

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