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Immunology
Brazil
2026
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Medicine
Brazil
2023

D-Index & Metrics

Immunology

D-Index
103
Citations
39180
World Ranking
640
National Ranking
3

Medicine

D-Index
103
Citations
39188
World Ranking
7364
National Ranking
14

Research.com Recognitions

  • 2026 - Research.com Immunology in Brazil Leader Award
  • 2025 - Research.com Immunology in Brazil Leader Award
  • 2023 - Research.com Immunology in Brazil Leader Award
  • 2023 - Research.com Medicine in Brazil Leader Award
  • 2022 - Research.com Immunology in Brazil Leader Award
  • 2022 - Research.com Medicine in Brazil Leader Award
  • 2010 - Fellow, The World Academy of Sciences
  • 2004 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Ricardo T. Gazzinelli is affiliated with the Universidade Federal de Minas Gerais in Brazil. Their research primarily spans medicine and immunology and microbiology, with a strong focus on infectious diseases and public health-related topics.

The scientist's recent publications include:

  • The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways (2022, Cell Reports)
  • γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis (2021, Nature Immunology)
  • Periodic Parasites and Daily Host Rhythms (2020, Cell Host & Microbe)
  • Regulation of innate immune signaling by IRAK proteins (2023, Frontiers in Immunology)
  • Behavioral alterations in long-term Toxoplasma gondii infection of C57BL/6 mice are associated with neuroinflammation and disruption of the blood brain barrier (2021, PLoS ONE)

Their frequent co-authors include Julia Castro, Santuza Maria Ribeiro Teixeira, Lis Ribeiro do Valle Antonelli, Douglas T. Golenbock, and Natália Satchiko Hojo-Souza.

Ricardo T. Gazzinelli's publications often appear in the following venues:

  • PLoS neglected tropical diseases
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • Cell Reports
  • Frontiers in Immunology

Their research covers several subfields, including:

  • Public Health, Environmental and Occupational Health
  • Epidemiology
  • Immunology
  • Infectious Diseases
  • Molecular Biology

Key topics in their work include:

  • Malaria Research and Control
  • Trypanosoma species research and implications
  • Research on Leishmaniasis Studies
  • SARS-CoV-2 and COVID-19 Research
  • Mosquito-borne diseases and control
  • Immune Response and Inflammation
  • COVID-19 Clinical Research Studies

Ricardo T. Gazzinelli has been recognized as a Fellow by The World Academy of Sciences in 2010 and as a Fellow of the John Simon Guggenheim Memorial Foundation in 2004.

Best Publications

  • In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

    Ricardo T. Gazzinelli;M. Wysocka;S Hieny;T Scharton-Kersten

  • Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming

    Robert A. Seder;Ricardo Gazzinelli;Alan Sher;William E. Paul

  • Regulation and Function of T-Cell-Mediated Immunity during Toxoplasma gondii Infection

    Eric Y. Denkers;Ricardo T. Gazzinelli

  • Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

    Ricardo T. Gazzinelli;Sara Hieny;Thomas A. Wynn;Stanley Wolf

  • IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

    R T Gazzinelli;I P Oswald;S L James;A Sher

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Andreas Acs

  • Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

    R T Gazzinelli;M Wysocka;S Hayashi;E Y Denkers

  • Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite.

    Marco A. S. Campos;Igor C. Almeida;Osamu Takeuchi;Shizuo Akira

  • Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine.

    R T Gazzinelli;F T Hakim;S Hieny;G M Shearer

  • Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.

    Peggy Parroche;Fanny N. Lauw;Nadege Goutagny;Eicke Latz

  • Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii.

    R Gazzinelli;Y Xu;S Hieny;A Cheever

  • The microbicidal activity of interferon-gamma-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-beta.

    Ricardo T. Gazzinelli;Isabel P. Oswald;Sara Hieny;Stephanie L. James

  • Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection.

    Alan Sher;Ricardo T. Gazzinelli;Isabelle P. Oswald;Mario Clerici

  • IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity.

    I P Oswald;R T Gazzinelli;A Sher;S L James

  • In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.

    T M Scharton-Kersten;T A Wynn;E Y Denkers;S Bala

  • Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-alpha and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation.

    R T Gazzinelli;I Eltoum;T A Wynn;A Sher

  • Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism

    Ricardo T. Gazzinelli;Ricardo T. Gazzinelli;Ricardo T. Gazzinelli;Eric Y. Denkers

  • Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease.

    Zigman Brener;Ricardo T. Gazzinelli

  • Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.

    Lucia Carrera;Ricardo T. Gazzinelli;Raffaello Badolato;Sara Hieny

  • Innate sensing of malaria parasites

    Ricardo T. Gazzinelli;Parisa Kalantari;Katherine A. Fitzgerald;Douglas T. Golenbock

  • In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal

    Ricardo Tostes Gazzinelli;Maria Wysocka;Sara Hieny;Tanya M Scharton-Kersten

Frequent Co-Authors

Alan Sher
Alan Sher National Institute of Allergy and Infectious Diseases
Douglas T. Golenbock
Douglas T. Golenbock University of Massachusetts Chan Medical School
Igor C. Almeida
Igor C. Almeida The University of Texas at El Paso
Mauricio M. Rodrigues
Mauricio M. Rodrigues Federal University of Sao Paulo
João S. Silva
João S. Silva Universidade de São Paulo
Mauro M. Teixeira
Mauro M. Teixeira Universidade Federal de Minas Gerais
Eric Y. Denkers
Eric Y. Denkers University of New Mexico
Sara Hieny
Sara Hieny National Institute of Allergy and Infectious Diseases
Alvaro J. Romanha
Alvaro J. Romanha Universidade Federal de Santa Catarina
Katherine A. Fitzgerald
Katherine A. Fitzgerald University of Massachusetts Chan Medical School

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