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Immunology

D-Index
61
Citations
13385
World Ranking
3237
National Ranking
1512

Overview

Eric Y. Denkers is affiliated with the University of New Mexico in the United States and specializes in immunology and microbiology, with significant contributions to parasitology and immunology. Their research interests span multiple subfields including epidemiology, emergency medical services, and public health.

The scientist has published extensively in areas related to parasitic infections, particularly focusing on Toxoplasma gondii and its interactions with the immune system. Their work includes studies on immune cell function and interaction, immune response and inflammation, and the diagnosis of parasitic infections. Additional research topics cover herpesvirus infections and treatments, cytomegalovirus and herpesvirus research, as well as pediatric health and respiratory diseases.

Notable recent papers include:

  • Toxoplasma gondii dense granule protein GRA24 drives MyD88-independent p38 MAPK activation, IL-12 production and induction of protective immunity, 2020, PLoS Pathogens
  • From Initiators to Effectors: Roadmap Through the Intestine During Encounter of Toxoplasma gondii With the Mucosal Immune System, 2021, Frontiers in Cellular and Infection Microbiology
  • Transcriptomics analysis of Toxoplasma gondii-infected mouse macrophages reveals coding and noncoding signatures in the presence and absence of MyD88, 2021, BMC Genomics
  • Induction of IL-12p40 and type 1 immunity by Toxoplasma gondii in the absence of the TLR-MyD88 signaling cascade, 2021, PLoS Pathogens
  • Impact of MyD88, Microbiota, and Location on Type 1 and Type 3 Innate Lymphoid Cells during Toxoplasma gondii Infection, 2022, ImmunoHorizons

Frequent co-authors in Denkers' research include Claire M. Doherty, Lindsay M. Snyder, Heather L. Mercer, Barbara A. Fox, and David J. Bzik. These collaborations reflect interdisciplinary efforts within their fields of study.

The scientist's publications are commonly found in journals such as Clinical & Experimental Immunology, PLoS Pathogens, The Journal of Immunology, Frontiers in Cellular and Infection Microbiology, and BMC Genomics. This demonstrates a consistent focus within immunology and infection-related research venues.

Best Publications

  • Regulation and Function of T-Cell-Mediated Immunity during Toxoplasma gondii Infection

    Eric Y. Denkers;Ricardo T. Gazzinelli

  • Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

    R T Gazzinelli;M Wysocka;S Hayashi;E Y Denkers

  • Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells.

    Charles A. Scanga;Julio Aliberti;Dragana Jankovic;Florence Tilloy

  • In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.

    T M Scharton-Kersten;T A Wynn;E Y Denkers;S Bala

  • Cross-Talk in the Innate Immune System: Neutrophils Instruct Recruitment and Activation of Dendritic Cells during Microbial Infection

    Soumaya Bennouna;Susan K. Bliss;Tyler J. Curiel;Eric Y. Denkers

  • Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism

    Ricardo T. Gazzinelli;Ricardo T. Gazzinelli;Ricardo T. Gazzinelli;Eric Y. Denkers

  • Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation

    Delbert S. Abi Abdallah;Charlotte E. Egan;Barbara A. Butcher;Eric Y. Denkers

  • Toxoplasma gondii Triggers Release of Human and Mouse Neutrophil Extracellular Traps

    Delbert S. Abi Abdallah;Changyou Lin;Carissa J. Ball;Michael R. King

  • Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection.

    Susan K. Bliss;Barbara A. Butcher;Eric Y. Denkers

  • Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control.

    Barbara A. Butcher;Barbara A. Fox;Leah M. Rommereim;Sung Guk Kim

  • Toxoplasma gondii tachyzoites inhibit proinflammatory cytokine induction in infected macrophages by preventing nuclear translocation of the transcription factor NF-kappa B.

    Barbara A. Butcher;Leesun Kim;Peter F. Johnson;Eric Y. Denkers

  • CXCR2 Deficiency Confers Impaired Neutrophil Recruitment and Increased Susceptibility During Toxoplasma gondii Infection

    Laura Del Rio;Soumaya Bennouna;Jesus Salinas;Eric Y. Denkers

  • IFN-γ Overproduction and High Level Apoptosis Are Associated with High but Not Low Virulence Toxoplasma gondii Infection

    L. Cristina Gavrilescu;Eric Y. Denkers

  • Human Polymorphonuclear Leukocytes Produce IL-12, TNF-α, and the Chemokines Macrophage-Inflammatory Protein-1α and -1β in Response to Toxoplasma gondii Antigens

    Susan K. Bliss;Anthony J. Marshall;Yin Zhang;Eric Y. Denkers

  • Neutrophil depletion during Toxoplasma gondii infection leads to impaired immunity and lethal systemic pathology.

    Susan K. Bliss;L. Cristina Gavrilescu;Ana Alcaraz;Eric Y. Denkers

  • Emergence of NK1.1+ cells as effectors of IFN-gamma dependent immunity to Toxoplasma gondii in MHC class I-deficient mice.

    E Y Denkers;R T Gazzinelli;D Martin;A Sher

  • Inflammation Drives Dysbiosis and Bacterial Invasion in Murine Models of Ileal Crohn’s Disease

    Melanie Craven;Charlotte E. Egan;Scot E. Dowd;Sean P. McDonough

  • A role for CD4+ NK1.1+ T lymphocytes as major histocompatibility complex class II independent helper cells in the generation of CD8+ effector function against intracellular infection.

    E Y Denkers;T Scharton-Kersten;S Barbieri;P Caspar

  • Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii.

    E Y Denkers;G Yap;T Scharton-Kersten;H Charest

  • Cutting Edge: IL-10-Independent STAT3 Activation by Toxoplasma gondii Mediates Suppression of IL-12 and TNF-α in Host Macrophages

    Barbara A. Butcher;Leesun Kim;Athanasia D. Panopoulos;Stephanie S. Watowich

Frequent Co-Authors

Alan Sher
Alan Sher National Institute of Allergy and Infectious Diseases
Ricardo T. Gazzinelli
Ricardo T. Gazzinelli Universidade Federal de Minas Gerais
Patricia Caspar
Patricia Caspar National Institute of Allergy and Infectious Diseases
Sara Hieny
Sara Hieny National Institute of Allergy and Infectious Diseases
Gregory A. Taylor
Gregory A. Taylor Duke University
Edward J. Pearce
Edward J. Pearce Johns Hopkins University
George S. Yap
George S. Yap Rutgers, The State University of New Jersey
Matthias Mack
Matthias Mack University of Regensburg
Louis Boon
Louis Boon University of Amsterdam
Scot E. Dowd
Scot E. Dowd MR DNA (Molecular Research LP)

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