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Immunology
USA
2026

D-Index & Metrics

Immunology

D-Index
161
Citations
99600
World Ranking
76
National Ranking
51

Medicine

D-Index
161
Citations
99614
World Ranking
750
National Ranking
427

Research.com Recognitions

  • 2026 - Research.com Immunology in United States Leader Award
  • 2025 - Research.com Immunology in United States Leader Award
  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Alan Sher is affiliated with the National Institute of Allergy and Infectious Diseases in the United States. Their research spans multiple areas of medicine and immunology, with a strong focus on infectious diseases and immune system function.

The main fields of their study include:

  • Medicine
  • Immunology and Microbiology

More specific subfields explored by Alan Sher encompass:

  • Immunology
  • Infectious Diseases
  • Epidemiology
  • Molecular Biology
  • Surgery

Research topics that dominate their work include:

  • Tuberculosis Research and Epidemiology
  • Immune Cell Function and Interaction
  • COVID-19 Clinical Research Studies
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • Immune responses and vaccinations
  • SARS-CoV-2 and COVID-19 Research

Alan Sher has contributed to a number of peer-reviewed publications in prominent venues. Frequent publication platforms include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Nature Immunology
  • The Journal of Experimental Medicine
  • Nature Communications

Some of their recent papers are:

  • Host-directed immunotherapy of viral and bacterial infections: past, present and future, 2022, Nature Reviews Immunology
  • Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis, 2020, Nature Immunology
  • PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques, 2021, Science Immunology
  • Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization, 2021, Nature Immunology
  • Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge, 2021, The Journal of Experimental Medicine

The scientist has collaborated frequently with the following coauthors:

  • Kerry L. Hilligan
  • Sivaranjani Namasivayam
  • Dragana Janković
  • Katrin D. Mayer-Barber
  • Daniel L. Barber

Alan Sher is also an author of a book titled The Covid-19 and TB Syndemic: Differences and Similarities, published in 2023 by Frontiers Media.

Among their recognitions, Alan Sher was made a Fellow of the American Association for the Advancement of Science (AAAS) in 2010.

Best Publications

  • Functional diversity of helper T lymphocytes.

    Abul K. Abbas;Kenneth M. Murphy;Alan Sher

  • Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.

    Steffen Jung;Julio Aliberti;Petra Graemmel;Mary Jean Sunshine

  • Type I interferons in infectious disease.

    Finlay McNab;Katrin Mayer-Barber;Alan Sher;Andreas Wack

  • Vaccine Adjuvants: Putting Innate Immunity to Work

    Robert L. Coffman;Alan Sher;Robert A. Seder

  • Cooperation of Toll-like receptor signals in innate immune defence.

    Giorgio Trinchieri;Alan Sher

  • Activation of Autophagy by Inflammatory Signals Limits IL-1β Production by Targeting Ubiquitinated Inflammasomes for Destruction

    Chong Shan Shi;Kevin Shenderov;Ning Na Huang;Juraj Kabat

  • TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

    Felix Yarovinsky;Dekai Zhang;John F. Andersen;Gerard L. Bannenberg

  • In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

    Ricardo T. Gazzinelli;M. Wysocka;S Hieny;T Scharton-Kersten

  • A Critical Role for IL-21 in Regulating Immunoglobulin Production

    Katsutoshi Ozaki;Rosanne Spolski;Carl G. Feng;Chen-Feng Qi

  • Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

    Makoto Arita;Francesca Bianchini;Julio Aliberti;Alan Sher

  • Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni.

    E J Pearce;P Caspar;J M Grzych;F A Lewis

  • Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming

    Robert A. Seder;Ricardo Gazzinelli;Alan Sher;William E. Paul

  • T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells

    Andre A. Lighvani;David M. Frucht;Dragana Jankovic;Hidehiro Yamane

  • In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas.

    Caetano Reis e Sousa;Sara Hieny;Tanya Scharton-Kersten;Dragana Jankovic

  • Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

    P Scott;P Natovitz;R L Coffman;E Pearce

  • Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

    Ricardo T. Gazzinelli;Sara Hieny;Thomas A. Wynn;Stanley Wolf

  • IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

    R T Gazzinelli;I P Oswald;S L James;A Sher

  • Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

    R T Gazzinelli;M Wysocka;S Hayashi;E Y Denkers

  • Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

    Katrin D. Mayer-Barber;Bruno B. Andrade;Sandra D. Oland;Eduardo P. Amaral;Eduardo P. Amaral

  • TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis

    André Báfica;Charles A Scanga;Carl G. Feng;Cynthia Leifer

  • In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal

    Ricardo Tostes Gazzinelli;Maria Wysocka;Sara Hieny;Tanya M Scharton-Kersten

Frequent Co-Authors

Sara Hieny
Sara Hieny National Institute of Allergy and Infectious Diseases
Dragana Jankovic
Dragana Jankovic National Institute of Allergy and Infectious Diseases
Allen W. Cheever
Allen W. Cheever National Institutes of Health
Patricia Caspar
Patricia Caspar National Institute of Allergy and Infectious Diseases
Stephanie L. James
Stephanie L. James National Institute of Allergy and Infectious Diseases
Ricardo T. Gazzinelli
Ricardo T. Gazzinelli Universidade Federal de Minas Gerais
Carl G. Feng
Carl G. Feng University of Sydney
Thomas A. Wynn
Thomas A. Wynn Pfizer (United States)
Edward J. Pearce
Edward J. Pearce Johns Hopkins University
George S. Yap
George S. Yap Rutgers, The State University of New Jersey

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