World's Best Scientists 2026 revealed!

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Immunology

D-Index
129
Citations
90031
World Ranking
238
National Ranking
156

Medicine

D-Index
129
Citations
90100
World Ranking
2531
National Ranking
1426

Overview

Thomas A. Wynn is affiliated with Pfizer in the United States and conducts research primarily in the fields of Medicine and Immunology and Microbiology. Their work spans various subfields, including Immunology, Molecular Biology, Genetics, Oncology, and Hepatology.

The scientist's research focuses on several main topics, which include:

  • IL-33, ST2, and ILC Pathways
  • Inflammatory Bowel Disease
  • Liver physiology and pathology
  • SARS-CoV-2 and COVID-19 Research
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Immune cells in cancer
  • Immune Cell Function and Interaction

Recent publications by Thomas A. Wynn reflect a range of topics related to inflammation, fibrogenesis, and immune responses. Selected notable papers include:

  • Fibrosis: from mechanisms to medicines, 2020, published in Nature
  • Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation, 2023, published in Science Immunology
  • Single-cell analyses of Crohn's disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions, 2021, published in Nature Communications
  • Regional Differences in Human Biliary Tissues and Corresponding In Vitro-Derived Organoids, 2020, published in Hepatology
  • Immune responses against SARS-CoV-2 variants after two and three doses of vaccine in B-cell malignancies: UK PROSECO study, 2022, published in Nature Cancer

Thomas A. Wynn has frequently collaborated with several co-authors, including Thomas Fabre, Richard L. Gieseck, Stephen M. Christensen, Shoh Asano, and Kathryn Bound. Their joint work has been published in a variety of scientific journals.

The scientist publishes often in venues such as bioRxiv (Cold Spring Harbor Laboratory), arXiv (Cornell University), Science Immunology, The Journal of Immunology, and UNC Libraries.

In addition to articles, Thomas A. Wynn has contributed to book publications, including a title released by Cambridge University Press:

  • The Materiality of Numbers, 2023

Best Publications

  • Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

    Peter J Murray;Judith E Allen;Subhra K Biswas;Edward A Fisher

  • Protective and pathogenic functions of macrophage subsets

    Peter J. Murray;Thomas A. Wynn

  • Cellular and molecular mechanisms of fibrosis.

    TA Wynn

  • Macrophage biology in development, homeostasis and disease

    Thomas A. Wynn;Ajay Chawla;Jeffrey W. Pollard;Jeffrey W. Pollard

  • Macrophages in Tissue Repair, Regeneration, and Fibrosis

    Thomas A. Wynn;Kevin M. Vannella

  • Mechanisms of fibrosis: therapeutic translation for fibrotic disease

    Thomas A Wynn;Thirumalai R Ramalingam

  • Fibrotic disease and the T H 1/T H 2 paradigm

    Thomas A. Wynn

  • Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases

    Thomas A. Wynn

  • Macrophages: master regulators of inflammation and fibrosis.

    Thomas A Wynn;Luke Barron

  • Fibrosis: from mechanisms to medicines

    Neil C. Henderson;Florian Rieder;Thomas A. Wynn

  • Integrating mechanisms of pulmonary fibrosis

    Thomas A. Wynn

  • IL-13 Effector Functions*

    Thomas A Wynn

  • Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

    Stephen J Galli;Niels Borregaard;Thomas A Wynn

  • Inflammation and metabolism in tissue repair and regeneration

    Sabine A. Eming;Thomas A. Wynn;Paul Martin;Paul Martin;Paul Martin

  • Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

    Ricardo T. Gazzinelli;Sara Hieny;Thomas A. Wynn;Stanley Wolf

  • Type 2 immunity in tissue repair and fibrosis

    Richard L. Gieseck;Mark S. Wilson;Thomas A. Wynn

  • Pulmonary fibrosis: pathogenesis, etiology and regulation

    M S Wilson;T A Wynn

  • Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of l-Arginine Metabolism

    Matthias Hesse;Manuel Modolell;Anne C. La Flamme;Marco Schito

  • Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

    John T. Pesce;Thirumalai R. Ramalingam;Margaret M. Mentink-Kane;Mark S. Wilson

  • Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent

    Mark S. Wilson;Satish K. Madala;Thirumalai R. Ramalingam;Bernadette R. Gochuico

  • The Role of Interleukin (IL)-10 in the Persistence of Leishmania major in the Skin after Healing and the Therapeutic Potential of Anti–IL-10 Receptor Antibody for Sterile Cure

    Yasmine Belkaid;Karl F. Hoffmann;Susana Mendez;Shaden Kamhawi

Frequent Co-Authors

Allen W. Cheever
Allen W. Cheever National Institutes of Health
Alan Sher
Alan Sher National Institute of Allergy and Infectious Diseases
Joseph F. Urban
Joseph F. Urban United States Department of Agriculture
Dragana Jankovic
Dragana Jankovic National Institute of Allergy and Infectious Diseases
Ying Shirley Meng
Ying Shirley Meng University of Chicago
Sara Hieny
Sara Hieny National Institute of Allergy and Infectious Diseases
Patricia Caspar
Patricia Caspar National Institute of Allergy and Infectious Diseases
Karl F. Hoffmann
Karl F. Hoffmann Aberystwyth University
Peter J. Murray
Peter J. Murray Max Planck Society
Nathan A. Mara
Nathan A. Mara University of Minnesota

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