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D-Index
46
Citations
19284
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18814
National Ranking
1466

Overview

Karl F. Hoffmann is affiliated with Aberystwyth University in the United Kingdom. Their research primarily spans the fields of Immunology and Microbiology, with 33 publications, and Medicine, also with 33 publications. Their work focuses heavily on Parasitology, a subfield reflected in 33 of their publications, along with areas such as Molecular Biology, Public Health, Environmental and Occupational Health, Ecology, and Infectious Diseases.

The main topics of Karl F. Hoffmann's research include Parasites and Host Interactions, covered in 66 publications, Parasite Biology and Host Interactions, Research on Leishmaniasis Studies, Helminth Infection and Control, Malaria Research and Control, Extracellular Vesicles in Disease, and Pneumocystis jirovecii Pneumonia Detection and Treatment.

Recent publications illustrate the focus on parasitic diseases and extracellular vesicles in this context. Notable papers include:

  • Large-scale RNAi screening uncovers therapeutic targets in the parasite Schistosoma mansoni, 2020, Science
  • DC-SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte-derived dendritic cells, 2020, Journal of Extracellular Vesicles
  • Special considerations for studies of extracellular vesicles from parasitic helminths: A community-led roadmap to increase rigour and reproducibility, 2023, Journal of Extracellular Vesicles
  • Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022, 2023, ACS Infectious Diseases
  • Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production, 2022, PLoS Pathogens

Karl F. Hoffmann has collaborated frequently with several researchers, including Josephine Forde-Thomas, Gilda Padalino, Iain W. Chalmers, Helen Whiteland, and Andrea Brancale. Their repeated collaborations suggest ongoing partnerships focused on parasitology and related biomedical fields.

Publication venues for Hoffmann's work include journals and platforms such as bioRxiv (Cold Spring Harbor Laboratory), where nine of their papers are available, Wellcome Open Research with four publications, ACS Infectious Diseases and PLoS Neglected Tropical Diseases each with three, and the Journal of Extracellular Vesicles with two.

Best Publications

  • Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

    Clotilde Théry;Kenneth W. Witwer;Elena Aikawa;Maria Jose Alcaraz

  • The Role of Interleukin (IL)-10 in the Persistence of Leishmania major in the Skin after Healing and the Therapeutic Potential of Anti–IL-10 Receptor Antibody for Sterile Cure

    Yasmine Belkaid;Karl F. Hoffmann;Susana Mendez;Shaden Kamhawi

  • IL-10 and the Dangers of Immune Polarization: Excessive Type 1 and Type 2 Cytokine Responses Induce Distinct Forms of Lethal Immunopathology in Murine Schistosomiasis

    Karl F. Hoffmann;Allen W. Cheever;Thomas A. Wynn

  • IL-10 is critical for host resistance and survival during gastrointestinal helminth infection

    Lisa R. Schopf;Karl F. Hoffmann;Allen W. Cheever;Joseph F. Urban

  • Whole genome analysis of a schistosomiasis-transmitting freshwater snail.

    Coen M Adema;Ladeana W Hillier;Catherine S Jones;Eric S Loker

  • Studies with Double Cytokine-Deficient Mice Reveal That Highly Polarized Th1- and Th2-Type Cytokine and Antibody Responses Contribute Equally to Vaccine-Induced Immunity to Schistosoma mansoni

    Karl F. Hoffmann;Stephanie L. James;Allen W. Cheever;Thomas A. Wynn

  • Cytokine-mediated host responses during schistosome infections; walking the fine line between immunological control and immunopathology.

    Karl F Hoffmann;Thomas A Wynn;David W Dunne

  • Protein and small non-coding RNA-enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni

    Fanny C. Nowacki;Martin T. Swain;Oleg I. Klychnikov;Umar Niazi

  • Immunopathology of schistosomiasis mansoni in mice and men

    Allen W Cheever;Karl F Hoffmann;Thomas A Wynn

  • Anti-schistosomal Intervention Targets Identified by Lifecycle Transcriptomic Analyses

    Jennifer M. Fitzpatrick;Emily Peak;Samirah Perally;Iain Wyllie Chalmers

  • Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type-1 and type-2 cytokine-mediated inflammatory reactions

    Karl F. Hoffmann;Thomas C. McCarty;David H. Segal;Monica Chiaramonte

  • An oligonucleotide microarray for transcriptome analysis of Schistosoma mansoni and its application/use to investigate gender-associated gene expression

    Jennifer M. Fitzpatrick;David A. Johnston;Gary W. Williams;Debbie J. Williams

  • Glycomic Analysis of Life Stages of the Human Parasite Schistosoma mansoni Reveals Developmental Expression Profiles of Functional and Antigenic Glycan Motifs

    Cornelis H. Smit;Angela van Diepen;D. Linh Nguyen;Manfred Wuhrer

  • Development and Validation of a Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability

    Emily Peak;Iain W. Chalmers;Karl F. Hoffmann

  • Schistosome egg production is dependent upon the activities of two developmentally regulated tyrosinases

    Jennifer M. Fitzpatrick;Yuriko Hirai;Hirohisa Hirai;Karl F. Hoffmann

  • Glycomics-driven discoveries in schistosome research

    Cornelis H. Hokke;André M. Deelder;Karl F. Hoffmann;Manfred Wuhrer

  • Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggs.

    Colin M. Fitzsimmons;Gabriele Schramm;Frances M. Jones;Iain W. Chalmers

  • Transcription of the Trypanosoma brucei spliced leader RNA gene is dependent only on the presence of upstream regulatory elements.

    Arthur Günzl;Elisabetta Ullu;Marion Dörner;Stenio P Fragoso

  • IFN-gamma, IL-12, and TNF-alpha are required to maintain reduced liver pathology in mice vaccinated with Schistosoma mansoni eggs and IL-12.

    Karl F. Hoffmann;Pat Caspar;Allen W. Cheever;Thomas A. Wynn

  • Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni

    Anne E Lockyer;Jenny Spinks;Richard A Kane;Karl F Hoffmann;Karl F Hoffmann

Frequent Co-Authors

Cornelis H. Hokke
Cornelis H. Hokke Leiden University Medical Center
David W. Dunne
David W. Dunne University of Cambridge
Thomas A. Wynn
Thomas A. Wynn Pfizer (United States)
Matthew Berriman
Matthew Berriman University of Glasgow
Allen W. Cheever
Allen W. Cheever National Institutes of Health
Paul J. Brindley
Paul J. Brindley George Washington University
Timothy P. Yoshino
Timothy P. Yoshino University of Wisconsin–Madison
Maria Yazdanbakhsh
Maria Yazdanbakhsh Leiden University Medical Center
Manfred Wuhrer
Manfred Wuhrer Leiden University Medical Center
Birgitte J. Vennervald
Birgitte J. Vennervald University of Copenhagen

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