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Biology and Biochemistry

D-Index
67
Citations
12059
World Ranking
8401
National Ranking
220

Overview

Cornelis H. Hokke is affiliated with Leiden University Medical Center in the Netherlands. Their research spans multiple fields within biomedical science, focusing strongly on parasitology and immunology, with a particular emphasis on host-parasite interactions.

Their primary fields of study include:

  • Medicine
  • Immunology and Microbiology

Within these areas, Hokke's subfields of study are:

  • Parasitology
  • Ecology
  • Molecular Biology
  • Immunology
  • Infectious Diseases

The main topics of Hokke's research focus on:

  • Parasites and Host Interactions
  • Parasite Biology and Host Interactions
  • Glycosylation and Glycoproteins Research
  • Trypanosoma species research and implications
  • Carbohydrate Chemistry and Synthesis
  • Monoclonal and Polyclonal Antibodies Research
  • Research on Leishmaniasis Studies

Hokke has contributed to multiple publications across various reputable scientific venues. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • PLoS neglected tropical diseases
  • Journal of Extracellular Vesicles
  • EBioMedicine

Among their recent papers are:

  • A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics (2020, Nature Medicine)
  • Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19 (2021, Nature Immunology)
  • DC-SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte-derived dendritic cells (2020, Journal of Extracellular Vesicles)
  • Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19 (2022, EBioMedicine)
  • Special considerations for studies of extracellular vesicles from parasitic helminths: A community-led roadmap to increase rigour and reproducibility (2023, Journal of Extracellular Vesicles)

Hokke often collaborates with other researchers. Frequent co-authors include:

  • Angela van Diepen
  • Maria Yazdanbakhsh
  • Meta Roestenberg
  • Paul L. A. M. Corstjens
  • Hermelijn H. Smits

Best Publications

  • Glycoproteomics based on tandem mass spectrometry of glycopeptides.

    Manfred Wuhrer;M. Isabel Catalina;André M. Deelder;Cornelis H. Hokke

  • Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses.

    Bart Everts;Georgia Perona-Wright;Hermelijn H. Smits;Cornelis H. Hokke

  • Glycosylation profiling of immunoglobulin G (IgG) subclasses from human serum

    Manfred Wuhrer;Jord C. Stam;Jord C. Stam;Fleur E. van de Geijn;Carolien A. M. Koeleman

  • Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor

    Bart Everts;Leonie Hussaarts;Nicole N. Driessen;Moniek H.J. Meevissen

  • Protein glycosylation analysis by liquid chromatography-mass spectrometry.

    Manfred Wuhrer;André M Deelder;Cornelis H Hokke

  • Hydrophilic Interaction Chromatography-Based High-Throughput Sample Preparation Method for N-Glycan Analysis from Total Human Plasma Glycoproteins

    L. Renee Ruhaak;Carolin Huhn;Willem Jan Waterreus;Arjen R. De Boer

  • LacdiNAc-glycans constitute a parasite pattern for galectin-3-mediated immune recognition.

    Timo K. van den Berg;Henk Honing;Niels Franke;Alexandra van Remoortere

  • Structural analysis of the sialylated N- and O-linked carbohydrate chains of recombinant human erythropoietin expressed in Chinese hamster ovary cells. Sialylation patterns and branch location of dimeric N-acetyllactosamine units

    C. H. Hokke;A. A. Bergwerff;G. W. K. Van Dedem;J. P. Kamerling

  • Various stages of Schistosoma express Lewisx, LacdiNAc, GalNAcβ1–4 (Fucα1–3)GlcNAc and GalNAcβ1–4(Fucα1–2Fucα1–3)GlcNAc carbohydrate epitopes: detection with monoclonal antibodies that are characterized by enzymatically synthesized neoglycoproteins

    Alexandra van Remoortere;Cornelis H.Hokke;Govert J.van Dam;Irma van Die

  • Murine Sperm-Zona Binding, A Fucosyl Residue Is Required for a High Affinity Sperm-binding Ligand A SECOND SITE ON SPERM BINDS A NONFUCOSYLATED, β-GALACTOSYL-CAPPED OLIGOSACCHARIDE

    Daniel S. Johnston;William W. Wright;Joel H. Shaper;Cornelis H. Hokke

  • Phase Variation in Helicobacter pylori Lipopolysaccharide due to Changes in the Lengths of Poly(C) Tracts in α3-Fucosyltransferase Genes

    Ben J. Appelmelk;Steve L. Martin;Mario A. Monteiro;Chris A. Clayton

  • Phase Variation in Helicobacter pylori Lipopolysaccharide

    B. J. Appelmelk;B. Shiberu;C. Trinks;N. Tapsi

  • Changes in antigen-specific IgG1 Fc N-glycosylation upon influenza and tetanus vaccination

    Maurice H.J. Selman;Sanne E. de Jong;Darius Soonawala;Frank P. Kroon

  • Protein glycosylation analyzed by normal-phase nano-liquid chromatography--mass spectrometry of glycopeptides.

    Manfred Wuhrer;Carolien A. M. Koeleman;Cornelis H. Hokke;André M. Deelder

  • Helminths and dendritic cells: sensing and regulating via pattern recognition receptors, Th2 and Treg responses.

    Bart Everts;Hermelijn H. Smits;Cornelis H. Hokke;Maria Yazdanbakhsh

  • Protein and small non-coding RNA-enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni

    Fanny C. Nowacki;Martin T. Swain;Oleg I. Klychnikov;Umar Niazi

  • Mass spectrometry of proton adducts of fucosylated N-glycans: fucose transfer between antennae gives rise to misleading fragments.

    Manfred Wuhrer;Carolien A. M. Koeleman;Cornelis H. Hokke;André M. Deelder

  • Decreased levels of bisecting GlcNAc glycoforms of IgG are associated with human longevity.

    L. Renee Ruhaak;Hae-Won Uh;Marian Beekman;Carolien A M A M Koeleman

  • Normal-Phase Nanoscale Liquid Chromatography -- Mass Spectrometry of Underivatized Oligosaccharides at Low-Femtomole Sensitivity

    Manfred Wuhrer;Carolien A. M. Koeleman;and André M. Deelder;Cornelis H. Hokke

  • Schistosome glycoconjugates in host-parasite interplay.

    Cornelis H. Hokke;André M. Deelder

Frequent Co-Authors

André M. Deelder
André M. Deelder Leiden University Medical Center
Manfred Wuhrer
Manfred Wuhrer Leiden University Medical Center
Maria Yazdanbakhsh
Maria Yazdanbakhsh Leiden University Medical Center
Karl F. Hoffmann
Karl F. Hoffmann Aberystwyth University
Johannis P. Kamerling
Johannis P. Kamerling Utrecht University
Hermelijn H. Smits
Hermelijn H. Smits Leiden University Medical Center
Johannes F.G. Vliegenthart
Johannes F.G. Vliegenthart Utrecht University
Helmut L. Haas
Helmut L. Haas Heinrich Heine University Düsseldorf
David W. Dunne
David W. Dunne University of Cambridge
Dirk Bosch
Dirk Bosch Wageningen University & Research

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