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Biology and Biochemistry

D-Index
58
Citations
10930
World Ranking
13294
National Ranking
332

Overview

Dirk Bosch is affiliated with Wageningen University & Research in the Netherlands, where their work spans biochemistry, genetics, molecular biology, and medicine. Their research focuses extensively on molecular biology and subfields such as cancer research, complementary and alternative medicine, biotechnology, and pharmacology.

The scientist's primary topics of study include sesquiterpenes and Asteraceae studies, microbial metabolic engineering and bioproduction, herbal medicine research, plant toxicity and pharmacological properties, natural product bioactivities and synthesis, plant biochemistry and biosynthesis, and biochemical and biochemical processes.

Dirk Bosch has contributed to multiple peer-reviewed publications. Recent papers include:

  • Production of indole by Corynebacterium glutamicum microbial cell factories for flavor and fragrance applications, 2022, Microbial Cell Factories
  • Inactivation of the germacrene A synthase genes by CRISPR/Cas9 eliminates the biosynthesis of sesquiterpene lactones in Cichorium intybus L., 2021, Plant Biotechnology Journal
  • Supercritical CO2 Extraction as a Tool to Isolate Anti-Inflammatory Sesquiterpene Lactones from Cichorium intybus L. Roots, 2021, Molecules
  • Costunolide and parthenolide: Novel blood-brain barrier permeable sesquiterpene lactones to improve barrier tightness, 2023, Biomedicine & Pharmacotherapy
  • The santalene synthase from Cinnamomum camphora: Reconstruction of a sesquiterpene synthase from a monoterpene synthase, 2020, Archives of Biochemistry and Biophysics

Their frequent co-authors include Katarina Cankar, Paul Bundock, Robert Sévenier, Johanna C. Hakkert, and Cláudia Nunes dos Santos. Publication venues where their work appears most commonly include Frontiers in Plant Science, Microbial Cell Factories, Plant Biotechnology Journal, Molecules, and Biomedicine & Pharmacotherapy.

Best Publications

  • Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes

    Teun W J M van Herpen;Svetlana V Goryunova;Svetlana V Goryunova;Johanna van der Schoot;Makedonka Mitreva;Makedonka Mitreva

  • Adaptation of Spodoptera exigua larvae to plant proteinase inhibitors by induction of gut proteinase activity insensitive to inhibition.

    Maarten A. Jongsma;Petra L. Bakker;Jeroen Peters;Dirk Bosch

  • Galactose-extended glycans of antibodies produced by transgenic plants.

    Hans Bakker;Muriel Bardor;Jos W. Molthoff;Véronique Gomord

  • De novo production of the flavonoid naringenin in engineered Saccharomyces cerevisiae

    Frank Koopman;Jules Beekwilder;Barbara Crimi;Adele van Houwelingen

  • The C-terminal KDEL sequence increases the expression level of a single-chain antibody designed to be targeted to both the cytosol and the secretory pathway in transgenic tobacco.

    Alexander Schouten;Jan Roosien;Fred A. van Engelen;G. A. M. (Ineke) de Jong

  • Natural Variation in Toxicity of Wheat: Potential for Selection of Nontoxic Varieties for Celiac Disease Patients

    Liesbeth Spaenij–Dekking;Yvonne Kooy–Winkelaar;Peter van Veelen;Jan Wouter Drijfhout

  • Bacillus thuringiensis toxin-mediated insect resistance in plants

    Ruud A. de Maagd;Dirk Bosch;Willem Stiekema

  • Domain III substitution in Bacillus thuringiensis delta-endotoxin CryIA(b) results in superior toxicity for Spodoptera exigua and altered membrane protein recognition.

    R.A. de Maagd;M.S.G. Kwa;H. van der Klei;T. Yamamoto

  • Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease

    Hetty C. van den Broeck;Hein C. de Jong;Elma M. J. Salentijn;Liesbeth Dekking;Liesbeth Dekking

  • Silencing the major apple allergen Mal d 1 by using the RNA interference approach.

    Luud J.W.J. Gilissen;Suzanne T.H.P. Bolhaar;Catarina I. Matos;Gerard J.A. Rouwendal

  • Nicotiana benthamiana as a production platform for artemisinin precursors.

    Teun W. J. M. van Herpen;Katarina Cankar;Marilise Nogueira;Dirk Bosch;Dirk Bosch

  • A synthetic cryIC gene, encoding a Bacillus thuringiensis δ-endotoxin, confers Spodoptera resistance in alfalfa and tobacco

    Nicolai Strizhov;Menachem Keller;Jaideep Mathur;Zsuzsanna Koncz-Kálmán

  • Recombinant Bacillus thuringiensis Crystal Proteins with New Properties: Possibilities for Resistance Management

    D Bosch;B Schipper;H van der Kleij;R A de Maagd

  • Coordinate expression of antibody subunit genes yields high levels of functional antibodies in roots of transgenic tobacco.

    van Engelen Fa;Schouten A;Molthoff Jw;Roosien J

  • Oral immunisation of naive and primed animals with transgenic potato tubers expressing LT-B

    T.G.M Lauterslager;D.E.A Florack;T.J van der Wal;J.W Molthoff

  • Expression of giant silkmoth cecropin B genes in tobacco.

    Dion Florack;Sjefke Allefs;Rik Bollen;Dirk Bosch

  • An antibody produced in tobacco expressing a hybrid beta-1,4-galactosyltransferase is essentially devoid of plant carbohydrate epitopes.

    Hans Bakker;Gerard J. A. Rouwendal;Anton S. Karnoup;Dion E. A. Florack

  • Effect of Climate Conditions and Plant Developmental Stage on the Stability of Antibodies Expressed in Transgenic Tobacco

    Lucas H. Stevens;Geert M. Stoopen;Ingrid J.W. Elbers;Jos W. Molthoff

  • Cross-resistance of the diamondback moth indicates altered interactions with domain II of Bacillus thuringiensis toxins.

    B E Tabashnik;T Malvar;Y B Liu;N Finson

  • Periplasmic accumulation of truncated forms of outer-membrane PhoE protein of Escherichia coli K-12

    Dirk Bosch;Jan Leunissen;John Verbakel;Marloes de Jong

Frequent Co-Authors

Jules Beekwilder
Jules Beekwilder Wageningen University & Research
Willem J. Stiekema
Willem J. Stiekema Norwich Research Park
Maarten A. Jongsma
Maarten A. Jongsma Wageningen University & Research
Jan Tommassen
Jan Tommassen Utrecht University
Harro J. Bouwmeester
Harro J. Bouwmeester University of Amsterdam
Marinus J. M. Smulders
Marinus J. M. Smulders Wageningen University & Research
Cornelis H. Hokke
Cornelis H. Hokke Leiden University Medical Center
Just M. Vlak
Just M. Vlak Wageningen University & Research
Stefan Schillberg
Stefan Schillberg Fraunhofer Society
Robert Hall
Robert Hall Royal Holloway University of London

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