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Genetics

D-Index
61
Citations
15882
World Ranking
3048
National Ranking
1330

Overview

Tyson A. Clark is a researcher affiliated with Pacific Biosciences in the United States. Their work primarily focuses on biochemistry, genetics, and molecular biology, with a total of 24 publications in these fields. Within this broad area, they have contributed extensively to molecular biology (21 publications), emergency medicine (4 publications), plant science (2 publications), cellular and molecular neuroscience (2 publications), and genetics (2 publications).

Their research covers diverse topics, including RNA modifications and cancer, epigenetics and DNA methylation, genomics and phylogenetic studies, genetic neurodegenerative diseases, mitochondrial function and pathology, DNA repair mechanisms, and cardiac arrest and resuscitation. The number of publications in these topics ranges from four to eight, reflecting a broad engagement with molecular and genetic mechanisms related to health and disease.

Clark has published multiple papers in various scientific venues. Frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), PLoS ONE, Circulation, Cancer Research, and Nature Communications. Their recent papers include the following:

  • Cost-efficient whole genome-sequencing using novel mostly natural sequencing-by-synthesis chemistry and open fluidics platform, 2022, bioRxiv (Cold Spring Harbor Laboratory)
  • Sex chromosome evolution in parasitic nematodes of humans, 2020, Nature Communications
  • Nearly Complete Genome Sequence of Brugia malayi Strain FR3, 2020, Microbiology Resource Announcements
  • Pulse-Field capillary electrophoresis of repeat-primed PCR amplicons for analysis of large repeats in Spinocerebellar Ataxia Type 10, 2020, PLoS ONE
  • Structural and functional diversity among Type III restriction-modification systems that confer host DNA protection via methylation of the N4 atom of cytosine, 2021, PLoS ONE

Clark has collaborated frequently with other researchers, including Jonas Korlach, Zohar Shipony, Doron Lipson, Yu-Chih Tsai, and Monique A. Starks. These frequent co-authors have contributed to various aspects of Clark's research themes, reflecting a collaborative approach within the molecular biology community.

Best Publications

  • Direct detection of DNA methylation during single-molecule, real-time sequencing

    Benjamin A Flusberg;Dale R Webster;Jessica H Lee;Kevin J Travers

  • HITS-CLIP yields genome-wide insights into brain alternative RNA processing

    Donny D. Licatalosi;Aldo Mele;John J. Fak;Jernej Ule

  • Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay

    Julie Z. Ni;Leslie Grate;John Paul Donohue;Christine Preston

  • Nova regulates brain-specific splicing to shape the synapse

    Jernej Ule;Aljaž Ule;Joanna Spencer;Alan Williams

  • Unveiling the complexity of the maize transcriptome by single-molecule long-read sequencing

    Bo Wang;Elizabeth Tseng;Michael Regulski;Tyson A Clark

  • Genomewide analysis of mRNA processing in yeast using splicing-specific microarrays.

    Tyson A. Clark;Charles W. Sugnet;Manuel Ares

  • Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array

    Paul J Gardina;Tyson A Clark;Brian Shimada;Michelle K Staples

  • Discovery of tissue-specific exons using comprehensive human exon microarrays

    Tyson A Clark;Anthony C Schweitzer;Tina X Chen;Michelle K Staples

  • Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing

    Gang Fang;Diana Munera;Diana Munera;David I Friedman;Anjali Mandlik;Anjali Mandlik

  • Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy

    Hongqing Du;Melissa S Cline;Robert J Osborne;Daniel L Tuttle

  • The Epigenomic Landscape of Prokaryotes

    Matthew J. Blow;Matthew J. Blow;Tyson A. Clark;Chris G. Daum;Chris G. Daum;Adam M. Deutschbauer

  • Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencing

    Tyson A. Clark;Iain A. Murray;Richard D. Morgan;Andrey O. Kislyuk

  • Single-molecule sequencing to track plasmid diversity of hospital-associated carbapenemase-producing Enterobacteriaceae.

    Sean Conlan;Pamela J. Thomas;Clayton Deming;Morgan Park

  • The methylomes of six bacteria

    Iain A. Murray;Tyson A. Clark;Richard D. Morgan;Matthew Boitano

  • Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB

    Miriam Llorian;Schraga Schwartz;Tyson A Clark;Dror Hollander

  • Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine

    Chun-Xiao Song;Tyson A Clark;Xing-Yu Lu;Andrey Kislyuk

  • Analysis of alternative splicing associated with aging and neurodegeneration in the human brain

    James R. Tollervey;Zhen Wang;Tibor Hortobágyi;Joshua T. Witten

  • Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation

    Nathan Salomonis;Christopher R. Schlieve;Laura Pereira;Christine Wahlquist

  • Unusual intron conservation near tissue-regulated exons found by splicing microarrays.

    Charles W Sugnet;Karpagam Srinivasan;Tyson A Clark;Georgeann O'Brien

  • A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity

    R. Stephanie Huang;Shiwei Duan;Wasim K. Bleibel;Emily O. Kistner

Frequent Co-Authors

Jonas Korlach
Jonas Korlach Pacific Biosciences (United States)
Richard J. Roberts
Richard J. Roberts New England Biolabs
Manuel Ares
Manuel Ares University of California, Santa Cruz
M. Eileen Dolan
M. Eileen Dolan University of Chicago
Eric E. Schadt
Eric E. Schadt Icahn School of Medicine at Mount Sinai
Shiwei Duan
Shiwei Duan Ningbo University
Michael P. Jennings
Michael P. Jennings Griffith University
Nancy J. Cox
Nancy J. Cox Vanderbilt University Medical Center
Jernej Ule
Jernej Ule The Francis Crick Institute
John S. Mattick
John S. Mattick University of New South Wales

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