World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
104
Citations
47036
World Ranking
643
National Ranking
326

Molecular Biology

D-Index
104
Citations
47036
World Ranking
462
National Ranking
260

Research.com Recognitions

  • 2011 - Fellow of Alfred P. Sloan Foundation

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Gene expression

Gene W. Yeo mostly deals with Genetics, RNA splicing, Alternative splicing, RNA-binding protein and Cell biology. As part of one scientific family, he deals mainly with the area of Genetics, narrowing it down to issues related to the Computational biology, and often Binding site. His research in RNA splicing intersects with topics in Molecular biology, splice, Intron and Exon.

His work carried out in the field of RNA-binding protein brings together such families of science as HEK 293 cells and Neurodegeneration. The study incorporates disciplines such as Chromatin, Non-coding RNA and Messenger RNA in addition to Cell biology. Gene W. Yeo has included themes like C9orf72 Protein, Promoter and C9orf72 in his RNA study.

His most cited work include:

  • Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals. (1285 citations)
  • A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells (1030 citations)
  • Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43 (805 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in RNA, Genetics, Cell biology, RNA-binding protein and RNA splicing. His RNA research includes themes of Transcriptome, Computational biology and Binding site. The concepts of his Cell biology study are interwoven with issues in Stress granule, Cell, Messenger RNA and Induced pluripotent stem cell.

His RNA-binding protein study also includes fields such as

  • Molecular biology that intertwine with fields like Ribonucleoprotein,
  • Gene expression and related Neurodegeneration. The study incorporates disciplines such as Intron, splice and Alternative splicing, Exon in addition to RNA splicing. His Gene research focuses on subjects like Amyotrophic lateral sclerosis, which are linked to Cytoplasm.

He most often published in these fields:

  • RNA (56.25%)
  • Genetics (46.38%)
  • Cell biology (44.41%)

What were the highlights of his more recent work (between 2019-2021)?

  • Cell biology (44.41%)
  • RNA (56.25%)
  • Computational biology (29.28%)

In recent papers he was focusing on the following fields of study:

Gene W. Yeo mainly focuses on Cell biology, RNA, Computational biology, RNA-binding protein and RNA splicing. His studies deal with areas such as Cell, Gene expression, Neurodegeneration, Messenger RNA and Exon as well as Cell biology. His research on RNA concerns the broader Gene.

His Computational biology research incorporates themes from CRISPR and Immunoprecipitation. His research integrates issues of Cancer research, Polyadenylation, Ribosomal RNA, Regulator and Ribosome in his study of RNA-binding protein. His RNA splicing research is multidisciplinary, relying on both Embryonic stem cell, Phosphofructokinase, MRNA modification and Untranslated region.

Between 2019 and 2021, his most popular works were:

  • Expanded encyclopaedias of DNA elements in the human and mouse genomes (141 citations)
  • A large-scale binding and functional map of human RNA-binding proteins (83 citations)
  • How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms. (51 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Gene expression

His primary scientific interests are in RNA, Computational biology, Cell biology, CD8 and RNA-binding protein. His RNA research includes elements of Nanopore sequencing, Messenger RNA and Immunoprecipitation. In his research on the topic of Computational biology, Phenotype, Stress granule and Genetic screen is strongly related with CRISPR.

His work deals with themes such as C9orf72, Neurodegeneration and Transmembrane protein, which intersect with Cell biology. RNA-binding protein is closely attributed to RNA splicing in his study. Gene W. Yeo has researched RNA splicing in several fields, including Embryonic stem cell, Polyadenylation, Function, Stem cell and MRNA modification.

Best Publications

  • Expanded encyclopaedias of DNA elements in the human and mouse genomes

    Jill E. Moore;Michael J. Purcaro;Henry E. Pratt;Charles B. Epstein

  • Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals.

    Gene W. Yeo;Christopher B. Burge

  • A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

    Maria C.N. Marchetto;Cassiano Carromeu;Allan Acab;Diana Yu

  • Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

    Magdalini Polymenidou;Clotilde Lagier-Tourenne;Kasey R. Hutt;Stephanie C. Huelga

  • Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)

    Eric L Van Nostrand;Gabriel A Pratt;Alexander A Shishkin;Chelsea Gelboin-Burkhart

  • Divergent Transcription from Active Promoters

    Amy C. Seila;J. Mauro Calabrese;Stuart S. Levine;Gene W. Yeo

  • A large-scale binding and functional map of human RNA-binding proteins

    Eric L. Van Nostrand;Peter Freese;Gabriel A. Pratt;Xiaofeng Wang

  • L1 Retrotransposition in Human Neural Progenitor Cells

    Nicole G. Coufal;José L. Garcia-Perez;José L. Garcia-Perez;Grace E. Peng;Gene W. Yeo;Gene W. Yeo

  • Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development.

    Cleber A. Trujillo;Richard Gao;Priscilla D. Negraes;Jing Gu

  • Systematic Identification and Analysis of Exonic Splicing Silencers

    Zefeng Wang;Michael E. Rolish;Gene Yeo;Vivian Tung

  • Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

    Clotilde Lagier-Tourenne;Magdalini Polymenidou;Kasey R. Hutt;Anthony Q. Vu

  • Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules.

    Sebastian Markmiller;Sahar Soltanieh;Kari L. Server;Raymond Mak

  • Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis

    Tomoko Kuwabara;Jenny Hsieh;Alysson Muotri;Gene Yeo

  • Variation in alternative splicing across human tissues

    Gene Yeo;Dirk Holste;Gabriel Kreiman;Christopher B Burge

  • L1 retrotransposition in neurons is modulated by MeCP2

    Alysson R. Muotri;Maria C. N. Marchetto;Nicole G. Coufal;Ruth Oefner

  • An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells

    Gene W Yeo;Nicole G Coufal;Tiffany Y Liang;Tiffany Y Liang;Grace E Peng

  • Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration

    Clotilde Lagier-Tourenne;Michael Baughn;Frank Rigo;Shuying Sun

  • Noncoding RNAs in the mammalian central nervous system.

    Xinwei Cao;Gene Yeo;Alysson R. Muotri;Tomoko Kuwabara

  • Programmable RNA Tracking in Live Cells with CRISPR/Cas9

    David A. Nelles;Mark Y. Fang;Mitchell R. O’Connell;Jia L. Xu

  • Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping

    Yuanchao Xue;Yu Zhou;Yu Zhou;Tongbin Wu;Tuo Zhu

Frequent Co-Authors

Fred H. Gage
Fred H. Gage Salk Institute for Biological Studies
Xiang-Dong Fu
Xiang-Dong Fu Westlake University
Brenton R. Graveley
Brenton R. Graveley University of Connecticut Health Center
John T. Chang
John T. Chang University of California, San Diego
Alysson R. Muotri
Alysson R. Muotri University of California, San Diego
Frank B. Furnari
Frank B. Furnari University of California, San Diego
Clotilde Lagier-Tourenne
Clotilde Lagier-Tourenne Harvard University
Paul S. Mischel
Paul S. Mischel Stanford University
Don W. Cleveland
Don W. Cleveland University of California, San Diego

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